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9 条记录 (耗时 0.048 秒)

    Transmetalations from zirconium to copper intermediates
    4.
    发明授权
    Transmetalations from zirconium to copper intermediates 失效
    从ZIRCONIUM到铜中间体的传输

    公开(公告)号：US5072010A

    公开(公告)日：1991-12-10

    申请号：US504370

    申请日：1990-04-04

    申请人： Bruce H. Lipshutz ,  Edmund L. Ellsworth

    发明人： Bruce H. Lipshutz ,  Edmund L. Ellsworth

    IPC分类号： C07C405/00 ,  C07F1/08

    CPC分类号： C07C405/00 ,  C07F1/08

    摘要： Higher order cuprate complexes are prepared by means of a transmetalation from a corresponding zirconate intermediate. This process is particularly valuable with respect to the preparation of vinylic side chains such as are present in prostaglandins, as it is possible in accordance with the present invention to proceed directly from the acetylenic precursors via the reactive cuprates to the desired final products in a one-pot operation without isolation of intermediates and in high yields. Sequential additions to zirconium intermediates of components which together comprise the cuprate involved in transmetalation with the zirconium intermediate are disclosed as alternative procedures.

    摘要翻译： 通过来自相应锆酸盐中间体的转化金属制备高级铜酸盐络合物。 该方法对于制备乙烯基侧链（例如存在于前列腺素中）是特别有价值的，因为根据本发明可能通过反应性铜酸盐从炔属前体直接进行到所需的最终产物 - 不分离中间体并以高产率进行操作。 作为替代方法公开了一起组合的锆中间体的顺序添加，其一起包括与锆中间体转铁合金的铜盐。

    Isoxazoline oximes as antiparasitic agents
    5.
    发明授权
    Isoxazoline oximes as antiparasitic agents 有权
    异恶唑啉作为抗寄生虫剂

    公开(公告)号：US08404649B2

    公开(公告)日：2013-03-26

    申请号：US13233459

    申请日：2011-09-15

    申请人： Michael Curtis ,  Edmund L. Ellsworth

    发明人： Michael Curtis ,  Edmund L. Ellsworth

    IPC分类号： A61K31/42 ,  A61K31/4402 ,  A61K31/5395 ,  A61P33/00 ,  C07D261/04

    CPC分类号： C07D261/04 ,  A01N43/80

    摘要： This invention recites naphthyl isoxazoline oxime derivatives of Formula (1) geometric isomers, stereoisomers thereof, pharmaceutically or veterinarily acceptable salts thereof, compositions thereof, and their use as a parasiticide in animals. The variables, R1a, R1b, R1c, R2, R3, and are as described herein.

    摘要翻译： 本发明叙述了式（1）的几何异构体的异恶唑啉肟衍生物，其立体异构体，其药学上或兽医学上可接受的盐，其组合物及其在动物中作为杀寄生虫剂的用途。 变量R1a，R1b，R1c，R2，R3，并且如本文所述。

    Tricyclic pyrone derivatives as protease inhibitors and antiviral agents
    6.
    发明授权
    Tricyclic pyrone derivatives as protease inhibitors and antiviral agents 失效
    三环吡喃酮衍生物作为蛋白酶抑制剂和抗病毒剂

    公开(公告)号：US5504104A

    公开(公告)日：1996-04-02

    申请号：US155412

    申请日：1993-11-19

    申请人： Edmund L. Ellsworth ,  Bradley D. Tait

    发明人： Edmund L. Ellsworth ,  Bradley D. Tait

    IPC分类号： C07D311/92 ,  C07D311/94 ,  A61K31/35 ,  C07D311/78

    CPC分类号： C07D311/94 ,  C07D311/92 ,  Y10S514/885

    摘要： The present invention relates to novel substituted tricyclic pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The tricyclic pyrone derivatives are useful in the development of therapies for the treatment of vital infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized tricyclic pyrones and of related structures.

    摘要翻译： 本发明涉及新型取代的三环pyrones和有效抑制HIV天冬氨酰蛋白酶阻断HIV感染性的相关结构。 三环吡喃酮衍生物可用于开发用于治疗重要感染和疾病（包括AIDS）的治疗。 本发明还涉及合成多功能三环pyrones和相关结构的方法。

    ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS
    7.
    发明申请
    ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS 有权
    ISOXAZOLINE OXIMES作为抗菌剂

    公开(公告)号：US20120077765A1

    公开(公告)日：2012-03-29

    申请号：US13233459

    申请日：2011-09-15

    申请人： Michael Curtis ,  Edmund L. Ellsworth

    发明人： Michael Curtis ,  Edmund L. Ellsworth

    IPC分类号： A61K31/42 ,  A61P33/00 ,  A61K31/4402 ,  A61K31/5395 ,  C07D261/04 ,  A61K31/7048

    CPC分类号： C07D261/04 ,  A01N43/80

    摘要： This invention recites naphthyl isoxazoline oxime derivatives of Formula (1) geometric isomers, stereoisomers thereof, pharmaceutically or veterinarily acceptable salts thereof, compositions thereof, and their use as a parasiticide in animals. The variables, R1a, R1b, R1c, R2, R3, and are as described herein.

    摘要翻译： 本发明叙述了式（1）的几何异构体的异恶唑啉肟衍生物，其立体异构体，其药学上或兽医学上可接受的盐，其组合物及其在动物中作为杀寄生虫剂的用途。 变量R1a，R1b，R1c，R2，R3，并且如本文所述。

    Transmetalations from zirconium to copper intermediates
    8.
    发明授权
    Transmetalations from zirconium to copper intermediates 失效
    从锆到铜中间体的转化

    公开(公告)号：US5286889A

    公开(公告)日：1994-02-15

    申请号：US20492

    申请日：1993-02-22

    申请人： Bruce H. Lipshutz ,  Edmund L. Ellsworth

    发明人： Bruce H. Lipshutz ,  Edmund L. Ellsworth

    IPC分类号： C07C405/00 ,  C07F1/08 ,  C07D309/00

    CPC分类号： C07F1/08 ,  C07C405/00

    摘要： Higher order cuprate complexes are prepared by means of a transmetalation from a corresponding zirconate intermediate. This process is particularly valuable with respect to the preparation of vinylic side chains such as are present in prostaglandins, as it is possible in accordance with the present invention to proceed directly from the acetylenic precursors via the reactive cuprates to the desired final products in a one-pot operation without isolation of intermediates and in high yields. Sequential additions to zirconium intermediates of components which together comprise the cuprate involved in transmetalation with the zirconium intermediate are disclosed as alternative procedures.

    摘要翻译： 通过来自相应锆酸盐中间体的转化金属制备高级铜酸盐络合物。 该方法对于制备乙烯基侧链（例如存在于前列腺素中）是特别有价值的，因为根据本发明可能通过反应性铜酸盐从炔属前体直接进行到所需的最终产物 - 不分离中间体并以高产率进行操作。 作为替代方法公开了一起组合的锆中间体的顺序添加，其一起包括与锆中间体转铁合金的铜盐。

    Transmetalations from zirconium to copper intermediates
    9.
    发明授权
    Transmetalations from zirconium to copper intermediates 失效
    从锆到铜中间体的转化

    公开(公告)号：US5166382A

    公开(公告)日：1992-11-24

    申请号：US747772

    申请日：1991-08-20

    申请人： Bruce Howard ,  Edmund L. Ellsworth

    发明人： Bruce Howard ,  Edmund L. Ellsworth

    IPC分类号： C07C405/00 ,  C07F1/08

    CPC分类号： C07C405/00 ,  C07F1/08

    摘要： Higher order cuprate complexes are prepared by means of a transmetalation from a corresponding zirconate intermediate. This process is particularly valuable with respect to the preparation of vinylic side chains such as are present in prostaglandins, as it is possible in accordance with the present invention to proceed directly from the acetylenic precursors via the reactive cuprates to the desired final products in a one-pot operation without isolation of intermediates and in high yields. Sequential additions to zirconium intermediates of components which together comprise the cuprate involved in transmetalation with the zirconium intermediate are disclosed as alternative procedures.

    摘要翻译： 通过来自相应锆酸盐中间体的转化金属制备高级铜酸盐络合物。 该方法对于制备乙烯基侧链（例如存在于前列腺素中）是特别有价值的，因为根据本发明可能通过反应性铜酸盐从炔属前体直接进行到所需的最终产物 - 不分离中间体并以高产率进行操作。 作为替代方法公开了一起组合的锆中间体的顺序添加，其一起包括与锆中间体转铁合金的铜盐。