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1.发明授权Method and system for reversal of interactions between hydrophobically modified biopolymers and vesicles or cell membranes 有权用于逆转疏水改性的生物聚合物和囊泡或细胞膜之间相互作用的方法和系统公开(公告)号：US08664199B2
公开(公告)日：2014-03-04
申请号：US13209399
申请日：2011-08-13
Applicant: Matthew Dowling , Srinivasa R. Raghavan , Rakesh Kumar
Inventor： Matthew Dowling , Srinivasa R. Raghavan , Rakesh Kumar
IPC: A61K31/722
CPC classification number: A61K31/724 , A61L15/28 , A61L15/42 , A61L26/0023 , A61L26/0061 , A61L26/0076 , A61L2300/232 , A61L2400/04
Abstract: A method for reversing gelation of hydrophobically modified biopolymer attached to vesicle or cell membranes. The gelation of hydrophobically modified biopolymer attached to vesicles or cell membranes is reversed by application of a supramolecule, such as cyclodextrin, to the gelled composition. The supramolecule disrupts the interactions between the hydrophobically modified biopolymer and the vesicle or cell membrane, without affecting the structure of the membrane or the hydrophobically modified polymer to which the hydrophobic substituents are attached. A kit for treating wounds that includes a hydrophobically modified biopolymer and a supramolecule. The hydrophobically modified biopolymer is used to stop bleeding and the supramolecule is used to remove the hydrophobically modified biopolymer.
Abstract translation: 疏水改性的生物聚合物与囊泡或细胞膜连接的凝胶化方法。 连接到囊泡或细胞膜上的疏水改性的生物聚合物的凝胶化通过将超分子如环糊精施加到胶凝组合物来逆转。 超分子破坏疏水改性生物聚合物与囊泡或细胞膜之间的相互作用，而不影响疏水性取代基所连接的膜或疏水改性聚合物的结构。 用于治疗包含疏水改性生物聚合物和超分子的伤口的试剂盒。 疏水改性的生物聚合物用于止血，超分子用于除去疏水改性的生物聚合物。
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2.发明申请METHOD AND SYSTEM FOR REVERSAL OF INTERACTIONS BETWEEN HYDROPHOBICALLY MODIFIED BIOPOLYMERS AND VESICLES OR CELL MEMBRANES 有权水解改性生物聚合物与VESICLES或细胞膜之间相互作用的方法和系统公开(公告)号：US20120058970A1
公开(公告)日：2012-03-08
申请号：US13209399
申请日：2011-08-13
Applicant: Matthew Dowling , Srinivasa R. Raghavan , Rakesh Kumar
Inventor： Matthew Dowling , Srinivasa R. Raghavan , Rakesh Kumar
IPC: A61K31/722 , A61K31/734 , A61P7/04 , A61K31/717
CPC classification number: A61K31/724 , A61L15/28 , A61L15/42 , A61L26/0023 , A61L26/0061 , A61L26/0076 , A61L2300/232 , A61L2400/04
Abstract: A method for reversing gelation of hydrophobically modified biopolymer attached to vesicle or cell membranes. The gelation of hydrophobically modified biopolymer attached to vesicles or cell membranes is reversed by application of a supramolecule, such as cyclodextrin, to the gelled composition. The supramolecule disrupts the interactions between the hydrophobically modified biopolymer and the vesicle or cell membrane, without affecting the structure of the membrane or the hydrophobically modified polymer to which the hydrophobic substituents are attached. A kit for treating wounds that includes a hydrophobically modified biopolymer and a supramolecule. The hydrophobically modified biopolymer is used to stop bleeding and the supramolecule is used to remove the hydrophobically modified biopolymer.
Abstract translation: 疏水改性的生物聚合物与囊泡或细胞膜连接的凝胶化方法。 连接到囊泡或细胞膜上的疏水改性的生物聚合物的凝胶化通过将超分子如环糊精施加到胶凝组合物来逆转。 超分子破坏疏水改性生物聚合物与囊泡或细胞膜之间的相互作用，而不影响疏水性取代基所连接的膜或疏水改性聚合物的结构。 用于治疗包含疏水改性生物聚合物和超分子的伤口的试剂盒。 疏水改性的生物聚合物用于止血，超分子用于除去疏水改性的生物聚合物。
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公开(公告)号：US11701393B2
公开(公告)日：2023-07-18
申请号：US17885784
申请日：2022-08-11
Applicant: Babita Agrawal , Rakesh Kumar , Nancy Gupta
Inventor： Babita Agrawal , Rakesh Kumar , Nancy Gupta
Abstract: The present disclosure provides immunomodulatory compositions comprising live Caulobacter crescentus (CC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising live CC to the individual.
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公开(公告)号：US11419904B2
公开(公告)日：2022-08-23
申请号：US17372614
申请日：2021-07-12
Applicant: Babita Agrawal , Rakesh Kumar , Nancy Gupta
Inventor： Babita Agrawal , Rakesh Kumar , Nancy Gupta
Abstract: The present disclosure provides immunomodulatory compositions comprising live Caulobacter crescentus (CC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising live CC to the individual.
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公开(公告)号：US20180000926A1
公开(公告)日：2018-01-04
申请号：US15543216
申请日：2016-01-15
Applicant: Babita Agrawal , Rakesh Kumar , Shakti Singh
Inventor： Babita Agrawal , Rakesh Kumar , Shakti Singh
CPC classification number: A61K39/12 , A61K39/0011 , A61K2039/5154 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/55561 , A61K2039/57 , A61K2039/572 , A61K2039/575 , C12N7/00 , C12N2710/10043 , C12N2770/24234 , C12N2770/24271
Abstract: The present disclosure provides methods for inducing an immune response to hepatitis C virus (HCV) in an individual. The present disclosure provides methods for treating an HCV infection in an individual.
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Patent Agency Ranking
公开(公告)号：US20160317637A1
公开(公告)日：2016-11-03
申请号：US15108744
申请日：2015-01-07
Applicant: Babita Agrawal , Rakesh Kumar
Inventor： Babita Agrawal , Rakesh Kumar
IPC: A61K39/02 , A61K39/35 , A61K39/395 , A61K39/00
CPC classification number: A61K39/02 , A61K39/0011 , A61K39/015 , A61K39/04 , A61K39/12 , A61K39/35 , A61K39/39 , A61K39/395 , A61K2039/505 , A61K2039/521 , A61K2039/55516 , A61K2039/55572 , A61K2039/58 , C12N2710/10343 , C12N2730/10134 , C12N2760/16134 , C12N2760/16234 , C12N2770/24234 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/487 , Y02A50/489 , Y02A50/491
Abstract: The present disclosure provides immunomodulatory compositions comprising heat-killed Caulobacter crescentus (HKCC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising HKCC to the individual.
Abstract translation: 本公开提供了包含热灭活的新月牙菌（HKCC）的免疫调节组合物。 本公开的免疫调节组合物可用于调节个体的免疫应答。 本公开因此提供调节个体的免疫应答的方法，包括向个体施用包含HKC的免疫调节组合物。
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7.发明授权Method and apparatus for generating three-dimensional pose using multi-modal sensor fusion 有权使用多模式传感器融合产生三维姿势的方法和装置公开(公告)号：US09031809B1
公开(公告)日：2015-05-12
申请号：US13182987
申请日：2011-07-14
Applicant: Rakesh Kumar , Supun Samarasekera , Han-Pang Chiu , Zhiwei Zhu , Taragay Oskiper , Lu Wang , Raia Hadsell
Inventor： Rakesh Kumar , Supun Samarasekera , Han-Pang Chiu , Zhiwei Zhu , Taragay Oskiper , Lu Wang , Raia Hadsell
CPC classification number: G01C21/165 , G01C21/005 , G01S1/00 , G01S5/163 , G06F3/012 , G06F3/017 , G06F3/0304 , G06K9/00671 , G06T7/246 , G06T7/277 , G06T7/285 , G06T2207/10021 , G06T2207/30244
Abstract: A method and apparatus for providing three-dimensional navigation for a node comprising an inertial measurement unit for providing gyroscope, acceleration and velocity information (collectively IMU information); a ranging unit for providing distance information relative to at least one reference node; at least one visual sensor for providing images of an environment surrounding the node; a preprocessor, coupled to the inertial measurement unit, the ranging unit and the plurality of visual sensors, for generating error states for the IMU information, the distance information and the images; and an error-state predictive filter, coupled to the preprocessor, for processing the error states to produce a three-dimensional pose of the node.
Abstract translation: 一种用于为节点提供三维导航的方法和装置，包括用于提供陀螺仪，加速度和速度信息（统称IMU信息）的惯性测量单元; 测距单元，用于相对于至少一个参考节点提供距离信息; 至少一个视觉传感器，用于提供围绕该节点的环境的图像; 耦合到惯性测量单元，测距单元和多个视觉传感器的预处理器，用于产生IMU信息，距离信息和图像的误差状态; 以及耦合到所述预处理器的错误状态预测滤波器，用于处理所述错误状态以产生所述节点的三维姿态。
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8.发明授权Pharmaceutical combination of pazopanib and topotecan to treat neuroblastoma, osteosarcoma, and rhabdomyosarcoma in a human 失效帕可帕尼与托泊替康的药物联合治疗人类的神经母细胞瘤，骨肉瘤和横纹肌肉瘤公开(公告)号：US08709420B2
公开(公告)日：2014-04-29
申请号：US13990515
申请日：2011-11-23
Applicant: Rakesh Kumar , Sylvain Baruchel
Inventor： Rakesh Kumar , Sylvain Baruchel
IPC: A61K45/06
CPC classification number: A61K31/506 , A61K31/4375 , A61K31/4745 , A61K2300/00
Abstract: The present invention relates to methods of treating neuroblastoma, osteosarcoma, and rhabdomyosarcoma in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a neuroblastoma treatment method that includes administering 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione, or a pharmaceutically acceptable salt thereof, to a human in need thereof.
Abstract translation: 本发明涉及治疗人类的神经母细胞瘤，骨肉瘤和横纹肌肉瘤的方法以及用于这种治疗的药物组合。 特别地，该方法涉及神经母细胞瘤治疗方法，其包括施用5 - [[4 - [（2,3-二甲基-2H-吲唑-6-基）甲基氨基] -2-嘧啶基]氨基] -2-甲基苯磺酰胺， 或其药学上可接受的盐，和（S）-10 - [（二甲基氨基）甲基] -4-乙基-4,9-二羟基-1H-吡喃并[3'，4'：6,7]吲哚并[1,2 b]喹啉-3,14-（4H，12H） - 二酮或其药学上可接受的盐。
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9.发明授权Performance measurement in a network supporting multiprotocol label switching (MPLS) 有权支持多协议标签交换（MPLS）的网络中的性能测量公开(公告)号：US08638778B2
公开(公告)日：2014-01-28
申请号：US12557803
申请日：2009-09-11
Applicant: Kwok Keung Lee , Hsiang Ann Chen , Jason Xiaoguang Chen , Rakesh Kumar
Inventor： Kwok Keung Lee , Hsiang Ann Chen , Jason Xiaoguang Chen , Rakesh Kumar
IPC: H04L12/28
CPC classification number: H04L43/0852 , H04L41/5009 , H04L41/5019 , H04L43/087 , H04L43/106 , H04L45/50
Abstract: A method and apparatus to provide hop-by-hop tracking for a communication network is described. In one embodiment, a router verifies that a next downstream router supports tracking and in response, adds a tracking indicator and a timestamp to the data packet. An end router provides a compilation of all the timestamps back to the originating router.
Abstract translation: 描述了一种为通信网络提供逐跳跟踪的方法和装置。 在一个实施例中，路由器验证下一个下游路由器支持跟踪并作为响应，将跟踪指示符和时间戳添加到数据分组。 终端路由器提供所有时间戳的编译回到始发路由器。
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公开(公告)号：US08477631B2
公开(公告)日：2013-07-02
申请号：US12546867
申请日：2009-08-25
Applicant: Sthanunathan Ramakrishnan , Bijoy Bhukania , Jawaharlal Tangudu , Sarma S Gunturi , Jaiganesh Balakrishnan , Rakesh Kumar , Abhijit Kumar Das , Yogesh Darwhekar
Inventor： Sthanunathan Ramakrishnan , Bijoy Bhukania , Jawaharlal Tangudu , Sarma S Gunturi , Jaiganesh Balakrishnan , Rakesh Kumar , Abhijit Kumar Das , Yogesh Darwhekar
IPC: H04B7/00
CPC classification number: H04L12/12 , H04W24/00 , H04W28/18 , H04W52/028 , H04W84/12 , H04W84/18 , H04W88/02 , Y02D70/142 , Y02D70/144 , Y02D70/162 , Y02D70/23
Abstract: A receiver in a packet based communication system includes a programmable block and a detection block that detects at least one of an operating condition of the receiver and a protocol condition of the communication system. Further, the receiver includes a control circuit coupled to the programmable block that controls the programmable block to transition to a set of radio modes according to at least one of the operating condition and the protocol condition.
Abstract translation: 基于分组的通信系统中的接收机包括可编程块和检测接收机的操作条件和通信系统的协议条件中的至少一个的检测块。 此外，接收机包括耦合到可编程块的控制电路，其根据操作条件和协议条件中的至少一个控制可编程块向一组无线电模式转变。
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