公开(公告)号：US07758542B2

公开(公告)日：2010-07-20

申请号：US11604959

申请日：2006-11-28

申请人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid

发明人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid

IPC分类号： A61M31/00

CPC分类号： A61M25/0017 ,  A61F2/0027 ,  A61M25/04 ,  A61M25/1011 ,  A61M2210/1089

摘要： Several embodiments of an endourethral prosthesis, assembly, and attendant methods are provided for patients presenting with lower urinary tract symptoms (LUTS) or urinary retention. The endourethral prosthesis includes a reversibly expandable element disposed circumferentially about, and longitudinally along a tubular member adapted to receive urine. The tubular member is positionable within a lower urinary tract such that the reversibly expandable element operatively engages a structure of the lower urinary tract so as to prevent migration of the prosthesis so positioned. The reversibly expandible element is in non-reversible fluid communication with the tubular element for selective expansion thereof, the reversibly expandible element is further operatively engagable so as to discharge fluid non-reversibly received from the tubular member exterior to same.

摘要翻译： 为具有较低尿路症状（LUTS）或尿潴留的患者提供内尿道假体，组装和伴随方法的若干实施例。 内尿道假体包括可逆地扩张的元件，其沿着适于接收尿液的管状构件周向地纵向设置。 管状构件可定位在下尿路内，使得可逆扩张的元件可操作地接合下尿道的结构，以便防止如此定位的假体的移动。 可逆膨胀元件与管状元件不可逆地流体连通，用于其选择性膨胀，可逆膨胀元件进一步可操作地接合，从而将外部不可逆地从管状构件接收的流体排出到外部。

公开(公告)号：US07951064B2

公开(公告)日：2011-05-31

申请号：US11335147

申请日：2006-01-19

申请人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid

发明人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid

IPC分类号： A61F2/00

CPC分类号： A61M25/0017 ,  A61M2210/1085 ,  A61M2210/1089 ,  F21W2121/006 ,  Y10S128/25

摘要： An endourethral device is provided having an elongate member having proximal and distal segments, the elongate member positionable within a lower urinary tract so as to at least partially traverses a prostatic urethra. A proximal anchor, adapted to abuttingly engage portions of a bladder neck so as to at least proximally anchor the device, is supported at least indirectly by the proximal segment of said elongate member. The proximal anchor includes bladder engaging elements radially extending from the proximal segment of said elongate member, urine being freely dischargable about at least the proximal segment so as to substantially bathe the bladder neck therewith.

公开(公告)号：US20100241240A1

公开(公告)日：2010-09-23

申请号：US11993411

申请日：2006-06-20

申请人： Lloyd K. Willard ,  Mark J. Whalen ,  John M. Reid ,  Chad S. Smith ,  Charles L. Euteneuer

发明人： Lloyd K. Willard ,  Mark J. Whalen ,  John M. Reid ,  Chad S. Smith ,  Charles L. Euteneuer

IPC分类号： A61F2/04

CPC分类号： A61M27/008 ,  A61M2025/0681

摘要： A self adjusting and/or positioning indwelling urethral device is provided. The device generally includes a prostatic urethral stent body and a urethral anchoring element. The prostatic urethral stent body includes a preconfigured end portion for anchored receipt within a bladder with the urethral anchoring element extending from the prostatic urethral stent body via a linkage. Engagement of the proximal anchor, delimited by the preconfigured end portion of the stent body, with the bladder is no or minimal impact upon the trigone region.

摘要翻译： 提供自调节和/或定位留置尿道装置。 该装置通常包括前列腺尿道支架主体和尿道锚定元件。 前列腺尿道支架主体包括用于在膀胱内锚定收容的预配置端部，其中尿道锚固元件通过连杆从前列腺尿道支架主体延伸。 由支架主体的预配置的端部限定的近端锚定器与膀胱的接合对于三角区域是没有或最小的影响。

公开(公告)号：US20100241219A1

公开(公告)日：2010-09-23

申请号：US11993394

申请日：2006-06-20

申请人： Lloyd K. Willard ,  Mark J. Whalen ,  John M. Reid ,  Chad S. Smith ,  Charles L. Euteneuer ,  Paul Buscemi

发明人： Lloyd K. Willard ,  Mark J. Whalen ,  John M. Reid ,  Chad S. Smith ,  Charles L. Euteneuer ,  Paul Buscemi

IPC分类号： A61K9/14 ,  A61K31/517 ,  A61K31/27 ,  A61K31/435 ,  A61K31/18 ,  A61K31/4985 ,  A61K31/496 ,  A61K31/704 ,  A61K31/337 ,  A61M25/00 ,  A61F2/82

CPC分类号： A61M27/008 ,  A61M2025/0681

摘要： An adjunctive accessory article (25) for controlled release of at least a single physiologically active agent form an indwelling medical device so equipped is provided. The article is configurable as a tubular element upon a portion of the indwelling medical device, with barriers or facilitating coverings overlaying the carrier in furtherance of the controlled release of the active agent. To the extent that requires, affixation means for stable placement upon an indwelling device are further contemplated. Finally, a variety of application systems are described in connection to deployment of sleeve articles upon a portion of an indwelling device.

摘要翻译： 提供用于控制释放至少一种单一生理活性剂的辅助辅助制品（25），形成如此装备的留置医疗装置。 该制品可配置为一部分留置医疗装置上的管状元件，其中障碍物或促进覆盖载体的覆盖物以促进活性剂的受控释放。 在需要的程度上，进一步考虑了用于在留置装置上稳定放置的固定装置。 最后，结合套管制品在留置装置的一部分上的部署来描述各种应用系统。

公开(公告)号：US07048698B2

公开(公告)日：2006-05-23

申请号：US10179108

申请日：2002-06-24

申请人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid

发明人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid

IPC分类号： A61B51/03

CPC分类号： A61B5/1076 ,  A61M29/02 ,  A61M2025/0004 ,  A61M2205/3331 ,  A61M2210/1096

摘要： A urethral profile apparatus, assembly and appurtenant methodology is provided. The apparatus includes an elongate member having proximal and distal ends, the proximal end including a probe. The probe is selectively positionable within a urethral passageway by axial translation of the elongate member via the distal end, with the probe dimensioned so as to indicate constrictures of the urethral passageway.

摘要翻译： 提供尿道剖面装置，装配和附属方法。 该装置包括具有近端和远端的细长构件，近端包括探针。 通过经由远端的细长构件的轴向平移，探针可选择性地定位在尿道通道内，探针的尺寸设定为指示尿道通道的结构。

公开(公告)号：US06991596B2

公开(公告)日：2006-01-31

申请号：US10274027

申请日：2002-10-18

申请人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid ,  Mark Baumgartner

发明人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid ,  Mark Baumgartner

IPC分类号： A61F2/02

CPC分类号： A61M25/0017 ,  A61M25/0068 ,  A61M25/0074 ,  A61M25/02 ,  A61M25/10 ,  A61M2025/0175

摘要： An endourethral device including proximal and distal anchor assemblies selectively spaced apart by a device body is provided. The proximal anchor assembly is adapted to abuttingly engage at least portions of a bladder neck so as to at least proximally anchor said device, the distal anchor assembly being adapted to engage at least portions of a bulbous urethra so as to at least distally anchor said device. The body extends between the proximal and distal anchors assemblies, the device being adapted such that the anchors are selectively spaced apart for fixed positioning within a lower urinary tract in furtherance of a portion of the body at least partially traversing a prostatic urethra.

摘要翻译： 提供了包括由装置主体间隔开的近端和远端锚固组件的内尿道装置。 所述近端锚固组件适于邻接地接合膀胱颈部的至少一部分，以便至少近端锚定所述装置，所述远端锚固组件适于接合球形尿道的至少一部分，以便至少远端锚定所述装置 。 主体在近端和远端锚固组件之间延伸，该装置适于使锚固件选择性间隔开，用于固定地定位在下尿道内，以促进身体的至少部分穿过前列腺尿道的部分。

公开(公告)号：US06719709B2

公开(公告)日：2004-04-13

申请号：US09943975

申请日：2001-08-31

申请人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid

发明人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid

IPC分类号： A61B5103

CPC分类号： A61B5/208 ,  A61B5/036 ,  A61B5/205 ,  A61M25/04 ,  A61M2025/0008 ,  A61M2210/1085 ,  A61M2210/166

摘要： A diagnostic urethral assembly includes an elongate body having a fluid passageway and an elongate support member selectively positionable within the fluid passageway of the elongate body. The elongate body has a radially responsive wall segment that is being positionable within a lower urinary tract such that the radially responsive wall segment is adjacent a prostatic urethra. The elongate body is adapted to be in fluid communication with a bladder. The assembly has a first condition wherein the elongate support member is translatable relative to the elongate body so as to permit sequential and incremental radial compression of the radially responsive wall segment by the prostatic urethra in furtherance of defining architecture associated with the prostatic urethra and a second condition wherein fluid distally introduced into the elongate body radially expands the radially responsive wall segment into conforming engagement with the prostatic urethra in furtherance of obtaining a mold of same.

摘要翻译： 诊断尿道组件包括具有流体通道的细长主体和可选择性地定位在细长主体的流体通道内的细长支撑构件。 细长体具有径向响应的壁段，其可定位在下泌尿道内，使得径向响应的壁段邻近前列腺尿道。 细长体适于与膀胱流体连通。 该组件具有第一状态，其中细长支撑构件可相对于细长主体平移，以便允许前列腺尿道的径向响应的壁段的顺序和增量的径向压缩，从而有助于限定与前列腺尿道相关联的结构， 其中向远端引入细长体的流体径向地将径向地响应的壁段扩展成与前列腺尿道的吻合，以便获得其模具。

公开(公告)号：US08016742B2

公开(公告)日：2011-09-13

申请号：US11413540

申请日：2006-04-28

申请人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid

发明人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid

IPC分类号： A61F2/02

CPC分类号： A61M25/0017 ,  A61M2210/1085 ,  A61M2210/1089 ,  F21W2121/006 ,  Y10S128/25

摘要： An endourethral device is provided having an elongate member having proximal and distal segments, the elongate member positionable within a lower urinary tract so as to at least partially traverses a prostatic urethra. A proximal anchor, adapted to abuttingly engage portions of a bladder neck so as to at least proximally anchor the device, is supported at least indirectly by the proximal segment of said elongate member. The proximal anchor includes bladder engaging elements radially extending from the proximal segment of said elongate member, urine being freely dischargable about at least the proximal segment so as to substantially bathe the bladder neck therewith.

摘要翻译： 提供了具有细长构件的尿道内装置，所述细长构件具有近端段和远段，所述细长构件可定位在下泌尿道内，以便至少部分地穿过前列腺尿道。 近端锚，适于邻接地接合膀胱颈部的部分，以至少近端锚定装置，至少间接地由所述细长构件的近侧段支撑。 近端锚固件包括从所述细长构件的近侧段径向延伸的囊状接合元件，尿可以围绕至少近端段自由排出，以便基本上使膀胱颈部沐浴。

公开(公告)号：US07108655B2

公开(公告)日：2006-09-19

申请号：US10059100

申请日：2002-01-23

申请人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid

发明人： Mark J. Whalen ,  Lloyd K. Willard ,  John M. Reid

IPC分类号： A61F2/00

CPC分类号： A61M25/0017 ,  A61M2210/1085 ,  A61M2210/1089 ,  F21W2121/006 ,  Y10S128/25

摘要： An endourethral device is provided having an elongate member having proximal and distal segments, the elongate member positionable within a lower urinary tract so as to at least partially traverses a prostatic urethra. A proximal anchor, adapted to abuttingly engage portions of a bladder neck so as to at least proximally anchor the device, is supported at least indirectly by the proximal segment of said elongate member. The proximal anchor includes bladder engaging elements radially extending from the proximal segment of said elongate member, urine being freely dischargable about at least the proximal segment so as to substantially bathe the bladder neck therewith.

摘要翻译： 提供了具有细长构件的尿道内装置，所述细长构件具有近端段和远段，所述细长构件可定位在下泌尿道内，以便至少部分地穿过前列腺尿道。 近端锚，适于邻接地接合膀胱颈部的部分，以至少近端锚定装置，至少间接地由所述细长构件的近侧段支撑。 近端锚固件包括从所述细长构件的近侧段径向延伸的囊状接合元件，尿可以围绕至少近端段自由排出，以便基本上使膀胱颈部沐浴。

公开(公告)号：US5344395A

公开(公告)日：1994-09-06

申请号：US826959

申请日：1992-01-24

申请人： Mark J. Whalen ,  Lloyd K. Willard

发明人： Mark J. Whalen ,  Lloyd K. Willard

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B17/32 ,  A61B19/00 ,  A61M1/00 ,  A61M25/00

CPC分类号： A61B17/320783 ,  A61B17/22012 ,  A61B2017/22038 ,  A61B2017/22052 ,  A61B2017/22075 ,  A61B2017/320088 ,  A61B2090/3784 ,  A61B2217/005 ,  A61B2217/007

摘要： An apparatus and method for recanalization of a blood vessel obstruction by application of low frequency mechanical energy to a vessel site or by creation of cavitation at the vessel site. The system includes a catheter assembly having a wire located within and extending through a wire support tube and adapted to move axially therewith. A driving apparatus positioned at a proximal portion of the catheter assembly imparts energy to the wire to oscillate it axially. A tip is connected to a distal end of the wire and imparts low frequency mechanical energy or causes cavitation at the vessel site to recanalize it. Further, a fluid particle removal system can be incorporated within the catheter assembly to convey pressurized fluid via the wire support tube to the tip where the fluid is redirected in a proximal direction into a second tube of the catheter assembly coaxially positioned around the wire support tube. Particulate from the vessel obstruction being recanalized becomes attached viscously in the redirected pressurized fluid and is withdrawn from the vessel site.

摘要翻译： 一种用于通过将低频机械能施加到血管部位或通过在血管位置产生气穴而再次血管阻塞的装置和方法。 该系统包括导管组件，该导管组件具有位于并延伸穿过线支撑管并且适于与其轴向移动的线。 定位在导管组件的近端部分的驱动装置将电能赋予线以使其轴向摆动。 尖端连接到电线的远端并施加低频机械能，或在血管位置引起气穴以重新通气。 此外，流体颗粒去除系统可以结合在导管组件内以将加压流体经由线支撑管传送到尖端，其中流体在近端方向被重定向到同轴定位在线支撑管周围的导管组件的第二管中 。 来自血管阻塞的再通化的颗粒变得粘附在重新导向的加压流体中，并从血管位置取出。