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1.发明授权公开(公告)号：US07935071B2
公开(公告)日：2011-05-03
申请号：US11960145
申请日：2007-12-19
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A fluid removal apparatus comprising a blood removal catheter for insertion into a peripheral vein or artery and having a size 16 standard gage needle or less; a filter having a blood inlet port coupled to the blood removal catheter, a blood outlet port, an excess fluid removal port, and a blood flow passage with porous membrane which passes fluids to the fluid removal port and retains solutes of 60,000 Daltons or greater, and a blood return catheter for inserting into a peripheral vein or artery and having a size of 16 standard gage needle or less.
摘要翻译： 一种流体去除装置，包括用于插入到外周静脉或动脉中并具有尺寸16标准规格针或更小的止血导管; 过滤器，其具有联接到除血导管的血液入口端口，血液出口端口，多余的流体移除端口以及具有多孔膜的血流通道，其将流体传递到流体移除端口并保持60,000道尔顿或更大的溶质， 以及用于插入外周静脉或动脉并具有16个标准规格针或更小尺寸的血液回流导管。
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公开(公告)号：US07175809B2
公开(公告)日：2007-02-13
申请号：US10801059
申请日：2004-03-16
申请人： Mark Gelfand , John O'Mahony , Howard R. Levin
发明人： Mark Gelfand , John O'Mahony , Howard R. Levin
CPC分类号： A61M1/34 , A61M1/341 , A61M1/36 , A61M2205/3303 , A61M2205/3306 , A61M2205/3331 , A61M2205/3375 , A61M2205/50 , A61M2230/205 , A61M2230/005
摘要： A method and system for the extracorporeal treatment of blood to remove fluid from the fluid overloaded patient is disclosed that non-invasively measures an oxygen level in the venous blood. The oxygen blood level is used to detect when hypotension is about to occur in a patient. The oxygen level measurements are used as feedback signals. These feedback signals are applied to automatically control the rate of fluid extraction to achieve the desired clinical outcome and avoid precipitating a hypotensive crisis in the patient.
摘要翻译： 公开了一种用于体外处理血液以从流体过载患者中去除流体的方法和系统，其非侵入性地测量静脉血中的氧水平。 氧气血液浓度用于检测患者中何时会发生低血压。 氧气测量值用作反馈信号。 这些反馈信号被应用于自动控制流体提取的速率以达到期望的临床结果，并避免在患者体内产生低血压危象。
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公开(公告)号：US08603021B2
公开(公告)日：2013-12-10
申请号：US13098853
申请日：2011-05-02
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： An ultrafiltration filter for an extracorporeal blood circuit having an input for blood withdrawn from a human patient and a blood output for filtered blood to be infused into the patient including: a filter body having a length of at least 20 centimeters (cm) and an interior diameter of no greater than 1.5 cm; an input at a first end of the body to receive the withdrawn blood; an output at a second end of the body to discharge the filtered blood; a filter membrane in the body defining a blood passage through the body, wherein the membrane has an active filter membrane surface area of no greater than 0.2 meters squared (m2) and the filter membrane blocks passage of blood molecules having a molecular weight cut of greater than 60,000 Daltons and a volume of the blood passage in the filter being less than two percent of a cardiac output of the patient, and an ultrafiltrate output to the body and open to a side of the filter surface area opposite to the blood passage.
摘要翻译： 一种用于体外血液回路的超滤过滤器，其具有从人类患者抽出的血液的输入和用于输入到患者中的过滤血液的血液输出，包括：具有至少20厘米（cm）的长度和内部 直径不大于1.5厘米; 在身体的第一端的输入以接收所抽取的血液; 在身体的第二端处输出以排出经过滤的血液; 身体中的过滤膜限定穿过身体的血液通道，其中膜具有不大于0.2平方米（m2）的活性过滤膜表面积，并且过滤膜阻止具有更大分子量切割的血液分子的通过 超过60,000道尔顿，并且过滤器中的血液通道的体积小于患者的心输出量的2％，并且超滤液输出到身体并且向与血液通道相对的过滤器表面区域的一侧开口。
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公开(公告)号：US20110208106A1
公开(公告)日：2011-08-25
申请号：US13098853
申请日：2011-05-02
IPC分类号： A61M1/16
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： An ultrafiltration filter for an extracorporeal blood circuit having an input for blood withdrawn from a human patient and a blood output for filtered blood to be infused into the patient including: a filter body having a length of at least 20 centimeters (cm) and an interior diameter of no greater than 1.5 cm; an input at a first end of the body to receive the withdrawn blood; an output at a second end of the body to discharge the filtered blood; a filter membrane in the body defining a blood passage through the body, wherein the membrane has an active filter membrane surface area of no greater than 0.2 meters squared (m2) and the filter membrane blocks passage of blood molecules having a molecular weight cut of greater than 60,000 Daltons and a volume of the blood passage in the filter being less than two percent of a cardiac output of the patient, and an ultrafiltrate output to the body and open to a side of the filter surface area opposite to the blood passage.
摘要翻译： 一种用于体外血液回路的超滤过滤器，其具有从人类患者抽出的血液的输入和用于输入到患者中的过滤血液的血液输出，包括：具有至少20厘米（cm）的长度和内部 直径不大于1.5厘米; 在身体的第一端的输入以接收所抽取的血液; 在身体的第二端处输出以排出经过滤的血液; 身体中的过滤膜限定穿过身体的血液通道，其中膜具有不大于0.2平方米（m2）的活性过滤膜表面积，并且过滤膜阻止具有更大分子量切割的血液分子的通过 超过60,000道尔顿，并且过滤器中的血液通道的体积小于患者的心输出量的2％，并且超滤液输出到身体并且向与血液通道相对的过滤器表面区域的一侧开口。
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公开(公告)号：US06890315B1
公开(公告)日：2005-05-10
申请号：US09618759
申请日：2000-07-18
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A method and apparatus for ultrafiltration of blood operating by removing blood from a peripheral blood vessel at a rate of less than two percent of total cardiac output of a patient, extracting fluid at a rate of 0.1 liter to 1.0 liters per hour while retaining cells and proteins in the blood, and returning the concentrated blood to a secondary blood vessel is disclosed. Blood is removed and returned using small gage needles. As a pump circulates blood from the patient, a filter removes ultrafiltrate from the blood using duty cycle or pump control, and a transparent container collects the removed fluid.
摘要翻译： 一种通过以小于患者总心输出量的百分之二的速率从外周血管中除血的血液超滤操作的方法和装置，以每小时0.1升至1.0升的速率提取液体，同时保留细胞和 公开了血液中的蛋白质，并将浓缩血液返回到二次血管。 使用小规格针头取出血液并返回。 当泵从患者循环血液时，过滤器使用占空比或泵控制从血液中除去超滤液，并且透明容器收集去除的流体。
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6.发明授权公开(公告)号：US07311689B2
公开(公告)日：2007-12-25
申请号：US10642638
申请日：2003-08-19
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A method and apparatus for ultrafiltration of blood operating by removing blood from a peripheral blood vessel at a rate of less than two percent of total cardiac output of a patient, extracting fluid at a rate of 0.1 liter to 1.0 liters per hour while retaining cells and proteins in the blood, and returning the concentrated blood to a secondary blood vessel is disclosed. Blood is removed and returned using small gage needles. As a pump circulates blood from the patient, a filter removes ultrafiltrate from the blood using duty cycle or pump control, and a transparent container collects the removed fluid.
摘要翻译： 一种通过以小于患者总心输出量的百分之二的速率从外周血管中除血的血液超滤操作的方法和装置，以每小时0.1升至1.0升的速率提取液体，同时保留细胞和 公开了血液中的蛋白质，并将浓缩血液返回到二次血管。 使用小规格针头取出血液并返回。 当泵从患者循环血液时，过滤器使用占空比或泵控制从血液中除去超滤液，并且透明容器收集去除的流体。
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公开(公告)号：US20190000545A1
公开(公告)日：2019-01-03
申请号：US16019380
申请日：2018-06-26
申请人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
发明人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
IPC分类号： A61B18/14 , A61N7/02 , A61F7/12 , A61M5/142 , A61M5/172 , A61N1/28 , A61N1/32 , A61N1/36 , A61N1/40 , A61N5/04 , A61B18/00 , A61N7/00 , A61N1/362
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.
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公开(公告)号：US20150282877A1
公开(公告)日：2015-10-08
申请号：US14737254
申请日：2015-06-11
申请人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
发明人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
CPC分类号： A61B18/1492 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61F7/123 , A61F2007/126 , A61M5/14276 , A61M5/1723 , A61M2210/1082 , A61N1/28 , A61N1/32 , A61N1/326 , A61N1/36007 , A61N1/36017 , A61N1/36114 , A61N1/36117 , A61N1/3627 , A61N1/403 , A61N5/045 , A61N7/02 , A61N2007/003
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.
摘要翻译： 提供了用于热诱导的肾神经调节的方法和装置。 热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。 在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。 在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。 在一些实施方案中，热诱导的肾神经调节通过脉冲热疗法的递送来实现。
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公开(公告)号：US20140324016A1
公开(公告)日：2014-10-30
申请号：US14221536
申请日：2014-03-21
申请人： Mark Gelfand , Howard R. Levin
发明人： Mark Gelfand , Howard R. Levin
CPC分类号： A61K31/529 , A61K9/0004 , A61K9/0012 , A61K9/7007 , A61K31/135 , A61K31/52 , A61K45/06 , A61L29/146 , A61M5/14276 , A61M5/145 , A61M5/1723 , A61M2005/14513 , A61M2205/05 , A61M2205/50 , A61M2210/1082 , A61N1/0551 , A61N1/326 , A61N1/36007 , A61N1/36114 , A61N1/36117 , A61N1/3627
摘要： A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump or a drug eluding implant for targeted delivery of a nerve-blocking agent to the periarterial space of the renal artery.
摘要翻译： 一种用于通过植入用于阻断肾脏和/或从肾脏的肾神经信号的装置来治疗与交感神经肾神经活动升高相关的心脏和肾脏疾病的方法和装置。 该装置可以是药物泵或药物迂回植入物，用于将神经阻断剂靶向递送至肾动脉的动脉周围空间。
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公开(公告)号：US20140228739A1
公开(公告)日：2014-08-14
申请号：US14258802
申请日：2014-04-22
申请人： Mark E. Deem , Hanson Gifford, III , Denise Zarins , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
发明人： Mark E. Deem , Hanson Gifford, III , Denise Zarins , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要翻译： 提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。 预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗 晚期肾脏疾病。 本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。
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