公开(公告)号：US20070275010A1

公开(公告)日：2007-11-29

申请号：US10572229

申请日：2004-09-20

Applicant: Mark Feinberg ,  David Garber

Inventor： Mark Feinberg ,  David Garber

IPC: A61K39/12 ,  A61P31/12 ,  A61P31/18 ,  C12N15/63 ,  C12N15/86 ,  C12N5/10 ,  C12N7/00

CPC classification number: C12N15/86 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/57 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/24143 ,  C12N2740/16043 ,  C12N2740/16122 ,  C12N2740/16234

Abstract: Recombinant modified vaccinia Ankara vectors are provided having a null mutation in a gene necessary for replication of the recombinant modified vaccinia Ankara virus and at least one heterologous antigen. The disclosed vectors optionally encode at least one pro-apoptotic factor, at least one anti-apoptotic factor, at least one immunomodulator, and combinations thereof. Cells complementing the null mutation the disclosed vectors are also provided.

Abstract translation: 提供了重组修饰的牛痘安卡拉载体，其在重组修饰的痘苗病毒安卡拉病毒和至少一种异源抗原的复制所必需的基因中具有无效突变。 所公开的载体任选地编码至少一种促凋亡因子，至少一种抗凋亡因子，至少一种免疫调节剂及其组合。 还提供补充所公开载体的无效突变的细胞。

公开(公告)号：US5965124A

公开(公告)日：1999-10-12

申请号：US381637

申请日：1995-01-31

Applicant: Mark Feinberg ,  Raul Andino ,  Carolyn Louise Weeks-Levy ,  Patricia Anne Reilly

Inventor： Mark Feinberg ,  Raul Andino ,  Carolyn Louise Weeks-Levy ,  Patricia Anne Reilly

IPC: A61K39/00 ,  C07K14/02 ,  C07K14/035 ,  C07K14/105 ,  C07K14/11 ,  C07K14/14 ,  C07K14/235 ,  C07K14/28 ,  C12N15/86 ,  A01N63/00

CPC classification number: C07K14/005 ,  C07K14/235 ,  C07K14/28 ,  C12N15/86 ,  A61K39/00 ,  C07K2319/00 ,  C12N2710/16622 ,  C12N2720/12322 ,  C12N2730/10122 ,  C12N2760/16122 ,  C12N2770/32622

Abstract: Replication-competent recombinant viruses, particularly replication-competent recombinant polioviruses, which include (1) exogenous nucleic acid sequences which encode an exogenous polypeptide and (2) a nucleic acid sequence which encodes an artificial proteolytic cleavage site for a viral or cellular protease which proteolytically processes (cleaves) the precursor protein produced by the parent virus and uses therefor. The recombinant precursor is cleaved into the usual array of constituent proteins, freeing the exogenous polypeptide. Replication-competent recombinant viruses are useful as vaccines against bacterial, viral, fungal and yeast infections, parasitic diseases, cancer and allergies.

Abstract translation: 具有复制能力的重组病毒，特别是具有复制能力的重组体脊髓灰质炎病毒，其包括（1）编码外源多肽的外源核酸序列和（2）编码蛋白水解的病毒或细胞蛋白酶的人工蛋白水解切割位点的核酸序列 过程（切割）母体病毒产生的前体蛋白并用于其。 将重组前体切割成通常的组成蛋白阵列，释放外源多肽。 可复制的重组病毒可用作抗细菌，病毒，真菌和酵母菌感染，寄生虫病，癌症和过敏的疫苗。

公开(公告)号：US20050071344A1

公开(公告)日：2005-03-31

申请号：US10674974

申请日：2003-09-30

Applicant: Yen-Fu Chen ,  John Dunsmoir ,  Mark Feinberg ,  Abhay Pradhan ,  Hari Shankar

Inventor： Yen-Fu Chen ,  John Dunsmoir ,  Mark Feinberg ,  Abhay Pradhan ,  Hari Shankar

IPC: G06F17/30 ,  G06F7/00

CPC classification number: G06F17/30917

Abstract: The present invention comprises a Schema Generation Program (SGP) and Schema Update Program (SUP). The SGP creates an initial XML Schema and copies the database into a hashtable. At the occurrence of a query interval, the SGP compares the database to the hashtable. If the database is identical to the hashtable, then the SGP resets the query interval and repeats the comparison. If the database and the hashtable are not identical, then the SGP deletes the old hashtable, stores a copy of the database as a new hashtable, and creates a new XML Schema. The XML Schema is stored in the web server so that a registered party may access the XML Schema and check the validity of a group of data before sending the data to the web server as a proposed addition to the database. The SUP notifies registered parties of updates to the XML Schema.

Abstract translation: 本发明包括模式生成程序（SGP）和模式更新程序（SUP）。 SGP创建一个初始XML模式，并将数据库复制到散列表中。 在查询间隔发生时，SGP将数据库与哈希表进行比较。 如果数据库与哈希表相同，则SGP重置查询间隔并重复比较。 如果数据库和散列表不相同，则SGP将删除旧的散列表，将数据库的副本存储为新的散列表，并创建新的XML模式。 XML模式存储在Web服务器中，以便注册的方可以访问XML模式，并在将数据发送到Web服务器之前检查一组数据的有效性，作为数据库的建议添加。 SUP通知注册方对XML模式的更新。

公开(公告)号：US20050066026A1

公开(公告)日：2005-03-24

申请号：US10666796

申请日：2003-09-18

Applicant: Yen-Fu Chen ,  John Dunsmoir ,  Mark Feinberg ,  Abhay Pradhan ,  Hari Shankar

Inventor： Yen-Fu Chen ,  John Dunsmoir ,  Mark Feinberg ,  Abhay Pradhan ,  Hari Shankar

IPC: G06Q50/00 ,  G06F15/16 ,  G06Q30/00 ,  G06Q99/00 ,  H04L12/14 ,  H04L12/24 ,  H04L12/26 ,  G06F15/173

CPC classification number: G06Q30/0601 ,  H04L12/14 ,  H04L12/1496 ,  H04L41/06 ,  H04L41/22 ,  H04L41/5003 ,  H04L41/5009 ,  H04L41/5016 ,  H04L41/5029 ,  H04L41/5032 ,  H04L43/00 ,  H04L43/067 ,  H04L43/0811 ,  H04L43/0852 ,  H04L43/0888 ,  H04L43/16

Abstract: The present invention provides a method, apparatus, and computer program product for displaying real-time service level performance, breach, and guaranteed uniformity with automatic alerts and proactive rebating for a utility computing environment. Service level agreement parameters, based on a service level agreement between a customer and a service provider, are used to identify discrepancies in a promised service level for the utility computing environment. A real-time view of a current service level and the promised service level for the customer are displayed. When a discrepancy between the promised service level and the current service level occurs, a rebate is generated for the customer. Alerts identifying the discrepancy and its root cause are provided to the customer and the service provider for the discrepancy. Alerts may also be provided prior to the occurrence of the discrepancy so that an action may be performed to eliminate the potential discrepancy.

Abstract translation: 本发明提供了一种方法，装置和计算机程序产品，用于显示实时服务水平的性能，违反和保证的统一性，并为实用计算环境提供自动警报和主动回扣。 根据客户和服务提供商之间的服务级别协议，服务级别协议参数用于识别应用程序计算环境的承诺服务级别中的差异。 显示当前服务级别和客户承诺的服务级别的实时视图。 当承诺服务水平与当前服务水平出现差异时，会为客户生成回扣。 识别差异的警报及其根本原因被提供给客户和服务提供商的差异。 警报也可以在发生差异之前提供，以便可以执行动作以消除潜在的差异。