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公开(公告)号：US09718828B2
公开(公告)日：2017-08-01
申请号：US15250978
申请日：2016-08-30
发明人： Adrianus Petrus Antonius De Man , Jan-Gerard Sterrenburg , Hans C. A. Raaijmakers , Allard Kaptein , Arthur A. Oubrie , Johannes Bernardus Maria Rewinkel , Christiaan Gerardus Johannes Maria Jans , Jacobus C. H. M. Wijkmans , Tjeerd A. Barf , Alan B. Cooper , Ronald M. Kim , Sobhana Babu Boga , Hugh Y. Zhu , Xiaolei Gao , Xin Yao , Rajan Anand , Hao Wu , Shilan Liu , Chundao Yang , Abdul-Basit Alhassan , James Wang , Younong Yu , Jian Liu , Henry M. Vaccaro
IPC分类号： C07D487/04 , C07D497/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/52 , A61K31/53 , A61P19/02 , C07D519/00 , A61K45/06 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D513/04 , C07D471/04
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D513/04 , C07D519/00
摘要： Provided are 6-5 membered fused pyridine ring compounds according to Formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and their use in therapy. In particular, provided is the use of 6-5 membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
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2.发明授权公开(公告)号：US09790226B2
公开(公告)日：2017-10-17
申请号：US15019561
申请日：2016-02-09
发明人： Tjeerd A. Barf , Christiaan Gerardus Johannes Maria Jans , Adrianus Petrus Antonius de Man , Arthur A. Oubrie , Hans C. Raaijmakers , Johannes Bernardus Maria Rewinkel , Jan Gerard Sterrenburg , Jacobus C. H. M. Wijkmans
IPC分类号： C07D487/04 , A61K31/4985 , C07D519/00 , A61K31/501 , A61K31/506 , A61K31/55 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/55 , C07D519/00 , Y02A50/411
摘要： The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
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3.发明申请4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES AS BTK INHIBITORS 有权4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES和4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES作为BTK抑制剂公开(公告)号：US20160159810A1
公开(公告)日：2016-06-09
申请号：US15019561
申请日：2016-02-09
发明人： Tjeerd A. Barf , Christiaan Gerardus Johannes Maria Jans , Petrus Antonius de Adrianu Man , Arthur A. Oubrie , Hans C.A. Raaijmakers , Johannes Bernardus Maria Rewinkel , Jan-Gerard Sterrenburg , Jacobus C. H. M. Wijkmans
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/55 , C07D519/00 , Y02A50/411
摘要： The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
摘要翻译： 本发明涉及式（I）的6-5元稠合吡啶环化合物或其药学上可接受的盐，或涉及包含这些化合物的药物组合物及其在治疗中的用途。 特别地，本发明涉及根据式（I）的6-5元稠合吡啶环化合物在治疗布鲁丁酪氨酸激酶（Btk）介导的病症中的用途。
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公开(公告)号：US09758524B2
公开(公告)日：2017-09-12
申请号：US15019543
申请日：2016-02-09
发明人： Tjeerd A. Barf , Christiaan Gerardus Johannes Maria Jans , Adrianus Petrus Antonius de Man , Arthur A. Oubrie , Hans C. A. Raaijmakers , Johannes Bernardus Maria Rewinkel , Jan Gerard Sterrenburg , Jacobus C. H. M. Wijkmans
IPC分类号： A61K31/4985 , C07D487/04 , C07D519/00 , A61K31/501 , A61K31/506 , A61K31/55 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/55 , C07D519/00 , Y02A50/411
摘要： The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
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5.发明申请公开(公告)号：US20160151364A1
公开(公告)日：2016-06-02
申请号：US15019543
申请日：2016-02-09
发明人： Tjeerd A. Barf , Christiaan Gerardus Johannes Maria Jans , Petrus Antonius de Adrianu Man , Arthur A. Oubrie , Hans C. A. Raaijmakers , Johannes Bernardus Maria Rewinkel , Jan-Gerard Sterrenburg , Jacobus C. H. M. Wijkmans
IPC分类号： A61K31/4985 , A61K31/5377 , A61K31/55 , A61K31/506 , A61K31/501
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/55 , C07D519/00 , Y02A50/411
摘要： The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
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公开(公告)号：US10934296B2
公开(公告)日：2021-03-02
申请号：US16276161
申请日：2019-02-14
发明人： Tjeerd A. Barf , Christiaan Gerardus Johannes Maria Jans , Adrianus Petrus Antonius de Man , Arthur A. Oubrie , Hans C. A. Raaijmakers , Johannes Bernardus Maria Rewinkel , Jan Gerard Sterrenburg , Jacobus C. H. M. Wijkmans
IPC分类号： C07D487/04 , C07D519/00 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/55 , A61K31/5377
摘要： The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
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公开(公告)号：US10239883B2
公开(公告)日：2019-03-26
申请号：US15668385
申请日：2017-08-03
发明人： Tjeerd A. Barf , Christiaan Gerardus Johannes Maria Jans , Adrianus Petrus Antonius de Man , Arthur A. Oubrie , Hans C. A. Raaijmakers , Johannes Bernardus Maria Rewinkel , Jan Gerard Sterrenburg , Jacobus C. H. M. Wijkmans
IPC分类号： C07D487/04 , A61K31/4985 , C07D519/00 , A61K31/501 , A61K31/506 , A61K31/55 , A61K31/5377
摘要： The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
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公开(公告)号：US20230331729A1
公开(公告)日：2023-10-19
申请号：US17984242
申请日：2022-11-10
发明人： Tjeerd A. Barf , Christiaan Gerardus Johannes Maria Jans , Adrianus Petrus Antonius de Man , Arthur A. Oubrie , Hans C.A. Raaijmakers , Johannes Bernardus Maria Rewinkel , Jan Gerard Sterrenburg , Jacobus C.H.M. Wijkmans
IPC分类号： C07D487/04 , C07D519/00 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/55 , A61K31/5377
CPC分类号： C07D487/04 , C07D519/00 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/55 , A61K31/5377 , Y02A50/30
摘要： The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I)
or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.-
公开(公告)号：US20210230166A1
公开(公告)日：2021-07-29
申请号：US17142202
申请日：2021-01-05
发明人： Tjeerd A. Barf , Christiaan Gerardus Johannes Maria Jans , Adrianus Petrus Antonius de Man , Arthur A. Oubrie , Hans C.A. Raaijmakers , Johannes Bernardus Maria Rewinkel , Jan Gerard Sterrenburg , Jacobus C.H.M. Wijkmans
IPC分类号： C07D487/04 , C07D519/00 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/55 , A61K31/5377
摘要： The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
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公开(公告)号：US20190276456A1
公开(公告)日：2019-09-12
申请号：US16276161
申请日：2019-02-14
发明人： Tjeerd A. Barf , Christiaan Gerardus Johannes Maria Jans , Adrianus Petrus Antonius de Man , Arthur A. Oubrie , Hans C.A. Raaijmakers , Johannes Bernardus Maria Rewinkel , Jan Gerard Sterrenburg , Jacobus C.H.M. Wijkmans
IPC分类号： C07D487/04 , C07D519/00 , A61K31/55 , A61K31/5377 , A61K31/4985 , A61K31/506 , A61K31/501
摘要： The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
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