公开(公告)号：US09718828B2

公开(公告)日：2017-08-01

申请号：US15250978

申请日：2016-08-30

申请人： MERCK SHARP & DOHME CORP. ,  MERCK SHARP & DOHME B.V.

发明人： Adrianus Petrus Antonius De Man ,  Jan-Gerard Sterrenburg ,  Hans C. A. Raaijmakers ,  Allard Kaptein ,  Arthur A. Oubrie ,  Johannes Bernardus Maria Rewinkel ,  Christiaan Gerardus Johannes Maria Jans ,  Jacobus C. H. M. Wijkmans ,  Tjeerd A. Barf ,  Alan B. Cooper ,  Ronald M. Kim ,  Sobhana Babu Boga ,  Hugh Y. Zhu ,  Xiaolei Gao ,  Xin Yao ,  Rajan Anand ,  Hao Wu ,  Shilan Liu ,  Chundao Yang ,  Abdul-Basit Alhassan ,  James Wang ,  Younong Yu ,  Jian Liu ,  Henry M. Vaccaro

IPC分类号： C07D487/04 ,  C07D497/02 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/52 ,  A61K31/53 ,  A61P19/02 ,  C07D519/00 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D513/04 ,  C07D471/04

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K45/06 ,  C07D471/04 ,  C07D513/04 ,  C07D519/00

摘要： Provided are 6-5 membered fused pyridine ring compounds according to Formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and their use in therapy. In particular, provided is the use of 6-5 membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.

公开(公告)号：US09708270B2

公开(公告)日：2017-07-18

申请号：US14434524

申请日：2013-10-11

申请人： Merck Sharp & Dohme Corp.

发明人： Mariappan Chelliah ,  Hong Dong Chu ,  Jason M. Cox ,  John S. Debenham ,  Keith Eagen ,  Ping Lan ,  Clare London ,  Michael A. Plotkin ,  Unmesh Shah ,  Christopher Joseph Sinz ,  Zhongxiang Sun ,  Henry M. Vaccaro ,  Srikanth Venkatraman

IPC分类号： C07D401/12 ,  C07D491/107 ,  C07D221/20 ,  C07D201/04 ,  C07D401/04 ,  C07D405/10

CPC分类号： C07D221/20 ,  C07D401/04 ,  C07D401/12 ,  C07D405/10 ,  C07D491/107

摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.

公开(公告)号：US20150274672A1

公开(公告)日：2015-10-01

申请号：US14434524

申请日：2013-10-11

申请人： Mariappan CHELLIAH ,  Hong Dong CHU ,  Jason M. COX ,  John S. DEBENHAM ,  Keith EAGEN ,  Ping LAN ,  Clare LONDON ,  Michael A. PLOTKIN ,  Unmesh SHAH ,  Christopher Joseph SINZ ,  Zhongxiang SUN ,  Henry M. VACCARO ,  Skikanth KATRAMAN ,  MERCK SHARP & DOHME CORP.

发明人： Mariappan Chelliah ,  Hong Dong Chu ,  Jason M. Cox ,  John S. Debenham ,  Keith Eagen ,  Ping Lan ,  Clare London ,  Michael A. Plotkin ,  Unmesh Shah ,  Christopher Joseph Sinz ,  Zhongxiang Sun ,  Henry M. Vaccaro ,  Srikanth Venkatraman

IPC分类号： C07D221/20 ,  C07D401/04 ,  C07D491/107 ,  C07D405/10

CPC分类号： C07D221/20 ,  C07D401/04 ,  C07D401/12 ,  C07D405/10 ,  C07D491/107

摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.

摘要翻译： 本发明涉及由式（I）表示的化合物及其药学上可接受的盐，其可用于治疗或预防糖尿病，高脂血症，肥胖，炎症相关疾病及相关疾病和病症。 该化合物可用作G蛋白偶联受体GPR120的激动剂。 还包括药物组合物和治疗方法。