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公开(公告)号：US08709416B2
公开(公告)日：2014-04-29
申请号：US13332164
申请日：2011-12-20
申请人： Solomon Langermann , Linda Liu
发明人： Solomon Langermann , Linda Liu
IPC分类号： A61K39/395
CPC分类号： A61K38/177 , A61K31/675 , A61K45/06 , C07K14/70532 , C07K2319/33 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/423 , Y02A50/475 , Y02A50/478 , Y02A50/48 , A61K2300/00
摘要： Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed.
摘要翻译： 描述了使用治疗方案治疗癌症和感染性疾病的方法，其包括与增强剂（例如环磷酰胺）联合降低T细胞中的抑制性信号转导的化合物以产生有效的T细胞介导的应答。 还公开了包含可用于本发明方法的PD-1拮抗剂和增效剂的组合物。
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公开(公告)号：US20130230514A1
公开(公告)日：2013-09-05
申请号：US13312201
申请日：2011-12-06
申请人： Solomon Langermann , Linda Liu
发明人： Solomon Langermann , Linda Liu
IPC分类号： A61K38/17 , A61K45/06 , A61K31/675
CPC分类号： A61K38/177 , A61K31/675 , A61K45/06 , C07K14/70532 , C07K2319/33 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/423 , Y02A50/475 , Y02A50/478 , Y02A50/48 , A61K2300/00
摘要： Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed.
摘要翻译： 描述了使用治疗方案治疗癌症和感染性疾病的方法，其包括与增强剂（例如环磷酰胺）联合降低T细胞中的抑制性信号转导的化合物以产生有效的T细胞介导的应答。 还公开了包含可用于本发明方法的PD-1拮抗剂和增效剂的组合物。
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公开(公告)号：US20080138877A1
公开(公告)日：2008-06-12
申请号：US11682512
申请日：2007-03-06
申请人： Sergey M. Dzekunov , Hyung J. Lee , Linhong Li , Vininder Singh , Linda Liu , John W. Holaday
发明人： Sergey M. Dzekunov , Hyung J. Lee , Linhong Li , Vininder Singh , Linda Liu , John W. Holaday
CPC分类号： A61N1/0412 , A61K9/5068 , A61K48/0091 , A61N1/327 , C12M35/02 , C12N15/87 , C12N2740/10051 , C12N2840/203
摘要： The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a method and apparatus for the encapsulation of biologically-active substances in various cell populations in blood by electroporation to achieve therapeutically desirable changes in the physical characteristics of the various cell populations in blood.
摘要翻译： 本发明涉及将生物活性物质包封在各种细胞群中的方法和装置。 更具体地，本发明涉及通过电穿孔将生物活性物质包封在血液中的各种细胞群体中以实现血液中各种细胞群体的物理特性的理想上的改变的方法和装置。
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公开(公告)号：US07141425B2
公开(公告)日：2006-11-28
申请号：US10225446
申请日：2002-08-21
申请人： Sergey M. Dzekunov , Hyung J. Lee , Linhong Li , Vininder Singh , Linda Liu , John W. Holaday
发明人： Sergey M. Dzekunov , Hyung J. Lee , Linhong Li , Vininder Singh , Linda Liu , John W. Holaday
IPC分类号： C12N15/87
CPC分类号： A61N1/0412 , A61K9/5068 , A61K48/0091 , A61N1/327 , C12M35/02 , C12N15/87 , C12N2740/10051 , C12N2840/203
摘要： The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a method and apparatus for the encapsulation of biologically-active substances in various cell populations in blood by electroporation to achieve therapeutically desirable changes in the physical characteristics of the various cell populations in blood.
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公开(公告)号：US09005616B2
公开(公告)日：2015-04-14
申请号：US13392399
申请日：2010-08-31
申请人： Solomon Langermann , Linda Liu
发明人： Solomon Langermann , Linda Liu
CPC分类号： C07K14/70532 , A61K9/0019 , A61K38/00 , A61K38/1709 , A61K39/44 , C07K16/2827 , C07K2317/50 , C07K2317/56 , C07K2317/72 , C07K2319/30 , C07K2319/32 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N2800/52
摘要： Methods for modulating immune responses in a subject are provided. A preferred embodiment provides methods and compositions for reducing or inhibiting transplant rejection in a subject, preferably a human subject. Transplant rejection can be inhibited or reduced in a subject by administering an effective amount of B7-H4 polypeptide, fragments or fusions thereof to inhibit or reduce the biological activity of an immune cell or to reduce the amounts of proinflammatory molecules at a site of transplant. Th1, Th17 and Th22 cells are exemplary T cells that can be targeted for inhibition by B7-H4 polypeptides, fusion proteins or fragments thereof to inhibit or reduce inflammation.
摘要翻译： 提供了调节受试者中免疫应答的方法。 优选的实施方案提供用于减少或抑制受试者，优选人受试者的移植排斥的方法和组合物。 通过施用有效量的B7-H4多肽，其片段或融合物来抑制或降低免疫细胞的生物活性或减少移植部位的促炎症分子的量，可以抑制或减少受试者的移植排斥反应。 Th1，Th17和Th22细胞是可被B7-H4多肽，融合蛋白或其片段抑制或减少炎症的靶向的示例性T细胞。
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公开(公告)号：US20140356364A1
公开(公告)日：2014-12-04
申请号：US14239117
申请日：2012-08-15
申请人： Solomon Langermann , Linda Liu , Shannon Marshall
发明人： Solomon Langermann , Linda Liu , Shannon Marshall
CPC分类号： C07K16/2827 , C07K16/30 , C07K2317/565 , C07K2317/76 , C07K2317/77
摘要： The present invention relates to antibodies (including anti-B7-H4 antibodies) and their antigen-binding fragments and to other molecules (including fusion proteins that bind to the cognate antigen/receptor, etc.) that are capable of immunospecifically binding to B7-H4 and the uses of such molecules in the diagnosis and the treatment of cancer and other diseases. The invention particularly concerns the use of such molecules to retard or prevent tumor growth, inhibit tumor-mediated suppression, eliminate tumors and/or deplete or block the activity of tumor associated macrophages (“TAMs”) so as to alter their activity and/or decrease TAM—mediated immune suppression.
摘要翻译： 本发明涉及抗体（包括抗B7-H4抗体）及其抗原结合片段以及能够免疫特异性结合B7-抗体的其它分子（包括与同源抗原/受体结合的融合蛋白等） H4和这些分子在诊断和治疗癌症等疾病中的应用。 本发明特别涉及使用这种分子来延缓或预防肿瘤生长，抑制肿瘤介导的抑制，消除肿瘤和/或消耗或阻断肿瘤相关巨噬细胞（“TAM”）的活性，从而改变其活性和/或 减少TAM介导的免疫抑制。
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公开(公告)号：US20120114649A1
公开(公告)日：2012-05-10
申请号：US13332164
申请日：2011-12-20
申请人： Solomon Langermann , Linda Liu
发明人： Solomon Langermann , Linda Liu
IPC分类号： A61K39/395 , A61P31/18 , A61P31/16 , A61P31/20 , A61P31/22 , A61P37/04 , A61P31/04 , A61P35/02 , A61P31/12 , A61P31/10 , A61P33/02 , A61P33/06 , A61P35/00 , A61P31/14
CPC分类号： A61K38/177 , A61K31/675 , A61K45/06 , C07K14/70532 , C07K2319/33 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/423 , Y02A50/475 , Y02A50/478 , Y02A50/48 , A61K2300/00
摘要： Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed.
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公开(公告)号：US09676854B2
公开(公告)日：2017-06-13
申请号：US14239117
申请日：2012-08-15
申请人： Linda Liu , Shannon Marshall , Solomon Langermann
发明人： Linda Liu , Shannon Marshall , Solomon Langermann
IPC分类号： C07K16/28 , A61K39/395 , C07K16/30
CPC分类号： C07K16/2827 , C07K16/30 , C07K2317/565 , C07K2317/76 , C07K2317/77
摘要： The present invention relates to antibodies (including anti-B7-H4 antibodies) and their antigen-binding fragments and to other molecules (including fusion proteins that bind to the cognate antigen/receptor, etc.) that are capable of immunospecifically binding to B7-H4 and the uses of such molecules in the diagnosis and the treatment of cancer and other diseases. The invention particularly concerns the use of such molecules to retard or prevent tumor growth, inhibit tumor-mediated suppression, eliminate tumors and/or deplete or block the activity of tumor associated macrophages (“TAMs”) so as to alter their activity and/or decrease TAM—mediated immune suppression.
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公开(公告)号：US20120114648A1
公开(公告)日：2012-05-10
申请号：US13332154
申请日：2011-12-20
申请人： Solomon Langermann , Linda Liu
发明人： Solomon Langermann , Linda Liu
IPC分类号： A61K39/395 , A61P31/00 , A61P35/02 , A61P31/12 , A61P31/22 , A61P31/14 , A61P31/16 , A61P31/04 , A61P33/00 , A61P31/10 , A61P33/02 , A61P35/00 , A61P31/18
CPC分类号： A61K38/177 , A61K31/675 , A61K45/06 , C07K14/70532 , C07K2319/33 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/423 , Y02A50/475 , Y02A50/478 , Y02A50/48 , A61K2300/00
摘要： Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed.
摘要翻译： 描述了使用治疗方案治疗癌症和感染性疾病的方法，其包括与增强剂（例如环磷酰胺）联合降低T细胞中的抑制性信号转导的化合物以产生有效的T细胞介导的应答。 还公开了包含可用于本发明方法的PD-1拮抗剂和增效剂的组合物。
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公开(公告)号：US08114845B2
公开(公告)日：2012-02-14
申请号：US12547129
申请日：2009-08-25
申请人： Solomon Langermann , Linda Liu
发明人： Solomon Langermann , Linda Liu
IPC分类号： A61K38/16
CPC分类号： A61K38/177 , A61K31/675 , A61K45/06 , C07K14/70532 , C07K2319/33 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/423 , Y02A50/475 , Y02A50/478 , Y02A50/48 , A61K2300/00
摘要： Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed.
摘要翻译： 描述了使用治疗方案治疗癌症和感染性疾病的方法，其包括与增强剂（例如环磷酰胺）联合降低T细胞中的抑制性信号转导的化合物以产生有效的T细胞介导的应答。 还公开了包含可用于本发明方法的PD-1拮抗剂和增效剂的组合物。
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