- 专利标题： COMPOSITIONS OF PD-1 ANTAGONISTS AND METHODS OF USE
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申请号： US13332164申请日： 2011-12-20
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公开(公告)号： US20120114649A1公开(公告)日： 2012-05-10
- 发明人: Solomon Langermann , Linda Liu
- 申请人： Solomon Langermann , Linda Liu
- 专利权人： Amplimmune, Inc. Delaware
- 当前专利权人： Amplimmune, Inc. Delaware
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P31/18 ; A61P31/16 ; A61P31/20 ; A61P31/22 ; A61P37/04 ; A61P31/04 ; A61P35/02 ; A61P31/12 ; A61P31/10 ; A61P33/02 ; A61P33/06 ; A61P35/00 ; A61P31/14
摘要：
Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed.
公开/授权文献
- US08709416B2 Compositions of PD-1 antagonists and methods of use 公开/授权日：2014-04-29
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