发明授权
- 专利标题： Compositions of PD-1 antagonists and methods of use
- 专利标题（中）： PD-1拮抗剂的组合物和使用方法
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申请号： US12547129申请日： 2009-08-25
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公开(公告)号： US08114845B2公开(公告)日： 2012-02-14
- 发明人: Solomon Langermann , Linda Liu
- 申请人： Solomon Langermann , Linda Liu
- 申请人地址： US MD Rockville
- 专利权人： Amplimmune, Inc.
- 当前专利权人： Amplimmune, Inc.
- 当前专利权人地址： US MD Rockville
- 代理商 Andrea V. Lockenour; Edward R. Gimmi
- 主分类号： A61K38/16
- IPC分类号： A61K38/16
摘要：
Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed.
公开/授权文献
- US20100055102A1 COMPOSITIONS OF PD-1 ANTAGONISTS AND METHODS OF USE 公开/授权日：2010-03-04
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