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    Cardiac stimulation at high ventricular wall stress areas
    1.
    发明授权
    Cardiac stimulation at high ventricular wall stress areas 有权
    心室刺激在高心室壁应激区域

    公开(公告)号：US07725185B2

    公开(公告)日：2010-05-25

    申请号：US12070080

    申请日：2008-02-15

    申请人： Lili Liu ,  Rodney Salo

    发明人： Lili Liu ,  Rodney Salo

    IPC分类号： A61N1/365 ,  A61N1/05

    CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

    摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

    摘要翻译： 用电刺激治疗逆转心室重构的装置和方法。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

    Cardiac stimulation at high ventricular wall stress areas
    2.
    发明申请
    Cardiac stimulation at high ventricular wall stress areas 有权
    心室刺激在高心室壁应激区域

    公开(公告)号：US20050065568A1

    公开(公告)日：2005-03-24

    申请号：US10952346

    申请日：2004-09-28

    申请人： Lili Liu ,  Rodney Salo

    发明人： Lili Liu ,  Rodney Salo

    IPC分类号： A61N1/368 ,  A61N1/365

    CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

    摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

    摘要翻译： 用电刺激治疗逆转心室重构的装置和方法。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

    Cardiac stimulation at high ventricular wall stress areas
    3.
    发明申请
    Cardiac stimulation at high ventricular wall stress areas 有权

    公开(公告)号：US20080140144A1

    公开(公告)日：2008-06-12

    申请号：US12070080

    申请日：2008-02-15

    申请人： Lili Liu ,  Rodney Salo

    发明人： Lili Liu ,  Rodney Salo

    IPC分类号： A61N1/365

    CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

    摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

    Cardiac stimulation at high ventricular wall stress areas
    4.
    发明授权
    Cardiac stimulation at high ventricular wall stress areas 有权
    心室刺激在高心室壁应激区域

    公开(公告)号：US07346394B2

    公开(公告)日：2008-03-18

    申请号：US10952346

    申请日：2004-09-28

    申请人： Lili Liu ,  Rodney Salo

    发明人： Lili Liu ,  Rodney Salo

    IPC分类号： A61N1/362

    CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

    摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

    摘要翻译： 用电刺激治疗逆转心室重构的装置和方法。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

    Measuring content item effectiveness
    5.
    发明授权
    Measuring content item effectiveness 有权
    测量内容项目有效性

    公开(公告)号：US09031861B1

    公开(公告)日：2015-05-12

    申请号：US13242772

    申请日：2011-09-23

    申请人： Lili Liu ,  Chao Cai ,  Paul Liu ,  Sissie Ling-le Hsiao ,  Karl Pfleger

    发明人： Lili Liu ,  Chao Cai ,  Paul Liu ,  Sissie Ling-le Hsiao ,  Karl Pfleger

    IPC分类号： G06Q30/00 ,  G06Q30/02

    CPC分类号： G06Q30/0205

    摘要： Methods, systems, and computer program products are provided for measuring effectiveness of content items included in a campaign. One example method includes providing a corpus of campaigns, where a campaign defines parameters for presentation that specify circumstances under which content items are presented to users in response to requests. The corpus is filtered by identifying one or more candidate campaigns, where each of the identified candidate campaigns is associated with a geographic region and includes one or more constraints that permit pausing distribution of content items without compromising campaign goals. For each candidate campaign, one or more experimental geographic locations included in the geographic region are determined that are substantially representative of the region. Presentation of at least one of the content items is paused for a time period, and content item effectiveness is measured by comparing resource conversions for experimental and control geographic locations.

    摘要翻译： 提供了方法，系统和计算机程序产品，用于衡量活动中包含的内容项目的有效性。 一种示例性方法包括提供广告系列语料库，其中活动定义用于呈现的参数，其指定响应于请求将内容项呈现给用户的情况。 通过识别一个或多个候选活动来筛选语料库，其中每个所识别的候选活动与地理区域相关联，并且包括允许在不影响活动目标的情况下暂停分配内容项目的一个或多个约束。 对于每个候选活动，确定包括在地理区域中的一个或多个实验地理位置，其基本上代表该区域。 至少一个内容项的呈现暂停一段时间，通过比较实验和控制地理位置的资源转换来测量内容项有效性。

    Coronary vein dimensional sensor and fixation apparatus
    6.
    发明授权
    Coronary vein dimensional sensor and fixation apparatus 有权
    冠状静脉尺寸传感器和固定装置

    公开(公告)号：US08818507B2

    公开(公告)日：2014-08-26

    申请号：US12431301

    申请日：2009-04-28

    申请人： Lili Liu ,  Allan C. Shuros

    发明人： Lili Liu ,  Allan C. Shuros

    IPC分类号： A61N1/362 ,  A61B5/11 ,  A61N1/05 ,  A61B5/02 ,  A61N1/365 ,  A61B5/00 ,  A61B5/0215

    CPC分类号： A61N1/057 ,  A61B5/02 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/1076 ,  A61B5/1107 ,  A61B5/686 ,  A61B2562/0261 ,  A61N1/3627 ,  A61N1/36578 ,  A61N2001/0585

    摘要： A system and method for estimating a hemodynamic performance parameter value of a patient's heart. The system includes a pulse generator and a medical electrical lead implanted partially within a coronary vein of the heart. The lead includes at least one sensor located within the coronary vein configured to generate a signal indicative of at least one dimensional parameter of the coronary vein. Changes in the dimensional parameter during one or more cardiac cycles are measured. The hemodynamic performance parameter is estimated based on the change in the dimensional parameter of the coronary vein.

    摘要翻译： 一种用于估计患者心脏的血液动力学性能参数值的系统和方法。 该系统包括部分地植入心脏冠状静脉内的脉冲发生器和医用电线。 引线包括位于冠状静脉内的至少一个传感器，其构造成产生指示冠状静脉的至少一维参数的信号。 测量一个或多个心动周期内尺寸参数的变化。 基于冠状静脉尺寸参数的变化估计血流动力学性能参数。

    SYSTEM AND METHOD FOR RHYTHM IDENTIFICATION AND THERAPY DISCRIMINATION USING HEMODYNAMIC STATUS INFORMATION
    7.
    发明申请
    SYSTEM AND METHOD FOR RHYTHM IDENTIFICATION AND THERAPY DISCRIMINATION USING HEMODYNAMIC STATUS INFORMATION 审中-公开
    使用血液动力学状态信息进行RHYTHM识别和治疗分离的系统和方法

    公开(公告)号：US20100305635A1

    公开(公告)日：2010-12-02

    申请号：US12786074

    申请日：2010-05-24

    申请人： Lili Liu ,  Dan Li ,  Allan C. Shuros ,  James O. Gilkerson

    发明人： Lili Liu ,  Dan Li ,  Allan C. Shuros ,  James O. Gilkerson

    IPC分类号： A61N1/365 ,  A61N1/39

    CPC分类号： A61N1/36564 ,  A61B5/02028 ,  A61B5/0452 ,  A61N1/3622 ,  A61N1/36585 ,  A61N1/3962

    摘要： A system and method for controlling cardiac ventricular tachyarrhythmias by acquiring a pressure signal representative of coronary venous pressure (CVP) from a pressure sensor implanted within a coronary vein of the patient. A CVP index is derived based on the pressure signal. The onset of a ventricular tachyarrhythmia episode is detected based on a cardiac rates signal. The CVP index and the rate signal are monitored and, responsive to the rate signal indicating a sustained tachycardia episode during the episode monitoring period, anti-tachycardia therapy selectively withheld and the episode monitoring period is extended based on the CVP index.

    摘要翻译： 一种用于通过从植入在患者的冠状静脉内的压力传感器获取代表冠状静脉压（CVP）的压力信号来控制心室性心律失常的系统和方法。 基于压力信号导出CVP指数。 基于心率信号检测心室快速性心律失常事件的发作。 监测CVP指数和速率信号，并且响应于在发作监测期间指示持续性心动过速发作的速率信号，选择性地保留抗心动过速治疗，并且基于CVP指数扩大发作监测期。

    Seal for use with medical device and system
    8.
    发明申请
    Seal for use with medical device and system 失效
    用于医疗器械和系统的密封

    公开(公告)号：US20050090883A1

    公开(公告)日：2005-04-28

    申请号：US10617881

    申请日：2003-07-14

    申请人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher Zerby

    发明人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher Zerby

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0565 ,  A61N1/056 ,  A61N1/0573

    摘要： A seal adapted for use with medical devices is provided. The medical device may be a lead having a distal tip adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead assembly in one embodiment includes an atraumatic tip. A seal is provided within the lead tip assembly, which prevents or limits further entry of fluids through the lead tip. The lead may be a left ventricular lead with a hemostasis mechanism provided therewithin.

    摘要翻译： 提供适于与医疗装置一起使用的密封件。 医疗装置可以是具有适于植入在心脏上或周围的远端的引线，并且用于连接到用于监测或刺激心脏活动的系统。 在一个实施例中的引线组件包括无创伤的尖端。 在引线端头组件内提供密封件，其防止或限制流体进一步进入引线尖端。 铅可以是在其中设置有止血机构的左心室导联。

    Method of deploying a ventricular lead containing a hemostasis mechanism
    10.
    发明授权
    Method of deploying a ventricular lead containing a hemostasis mechanism 有权
    部署含有止血机制的心室导管的方法

    公开(公告)号：US06634364B2

    公开(公告)日：2003-10-21

    申请号：US09738590

    申请日：2000-12-15

    申请人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher M. Zerby

    发明人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher M. Zerby

    IPC分类号： A61N105

    CPC分类号： A61N1/0565 ,  A61N1/056 ,  A61N1/0573

    摘要： A seal adapted for use with medical devices is provided. The medical device may be a lead having a distal tip adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead assembly in one embodiment includes an atraumatic tip. A seal is provided within the lead tip assembly, which prevents or limits further entry of fluids through the lead tip. The lead may be a left ventricular lead with a hemostasis mechanism provided therewithin.

    摘要翻译： 提供适于与医疗装置一起使用的密封件。 医疗装置可以是具有适于植入在心脏上或周围的远端的引线，并且用于连接到用于监测或刺激心脏活动的系统。 在一个实施例中的引线组件包括无创伤的尖端。 在引线端头组件内提供密封件，其防止或限制流体进一步进入引线尖端。 铅可以是在其中设置有止血机构的左心室导联。