公开(公告)号：US08722346B2

公开(公告)日：2014-05-13

申请号：US13919877

申请日：2013-06-17

Applicant: Li-Cor, Inc.

Inventor： Ahmed Bouzid ,  Chris Lesiak ,  Daniel W. Konz ,  David L. Franzen ,  William Biggs ,  Jon P. Anderson

IPC: G01N33/53 ,  G01J1/04

CPC classification number: C12Q1/6825 ,  G01J1/0403 ,  G01N21/62 ,  G01N21/6486 ,  G01N21/76 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/54373 ,  H04N1/1017 ,  H04N1/191 ,  H04N1/1933

Abstract: Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.

Abstract translation: 公开了用于精确地成像化学发光和其它发光的系统，装置和方法。 一种紧凑的平板扫描器，具有不透光的外壳，一个或多个线性电荷耦合器件（CCD）或互补金属氧化物半导体（CMOS）成像芯片的检测棒，以及高工作数值孔径（NA）光学器件密切扫描 在一个方向上的样品上，然后是相反的方向。 将两个或更多遍之间的每个像素位置（x，y）的强度读数的平均值或其他组合平均在一起以便补偿随时间变化的发光。 可以使用片上像素分档和多个时钟频率来最大化基于CCD的扫描仪中的信噪比。

公开(公告)号：US20140206568A1

公开(公告)日：2014-07-24

申请号：US14223672

申请日：2014-03-24

Applicant: LI-COR, Inc.

Inventor： Ahmed Bouzid ,  Chris Lesiak ,  Daniel W. Konz ,  David L. Franzen ,  William Biggs ,  Jon P. Anderson

IPC: G01N21/76 ,  C12Q1/68 ,  G01N21/62 ,  G01N33/543

CPC classification number: C12Q1/6825 ,  G01J1/0403 ,  G01N21/62 ,  G01N21/6486 ,  G01N21/76 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/54373 ,  H04N1/1017 ,  H04N1/191 ,  H04N1/1933

Abstract: Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.

Abstract translation: 公开了用于精确地成像化学发光和其它发光的系统，装置和方法。 一种紧凑的平板扫描器，具有不透光的外壳，一个或多个线性电荷耦合器件（CCD）或互补金属氧化物半导体（CMOS）成像芯片的检测棒，以及高工作数值孔径（NA）光学器件密切扫描 在一个方向上的样品上，然后是相反的方向。 将两个或更多遍之间的每个像素位置（x，y）的强度读数的平均值或其他组合平均在一起以便补偿随时间变化的发光。 可以使用片上像素分档和多个时钟频率来最大化基于CCD的扫描仪中的信噪比。

公开(公告)号：US09809842B2

公开(公告)日：2017-11-07

申请号：US14223672

申请日：2014-03-24

Applicant: LI-COR, Inc.

Inventor： Ahmed Bouzid ,  Chris Lesiak ,  Daniel W. Konz ,  David L. Franzen ,  William Biggs ,  Jon P. Anderson

IPC: C12Q1/68 ,  G01N21/76 ,  H04N1/10 ,  H04N1/193 ,  G01N21/64 ,  G01J1/04 ,  G01N33/53 ,  G01N21/62 ,  G01N33/543 ,  H04N1/191

CPC classification number: C12Q1/6825 ,  G01J1/0403 ,  G01N21/62 ,  G01N21/6486 ,  G01N21/76 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/54373 ,  H04N1/1017 ,  H04N1/191 ,  H04N1/1933

Abstract: Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.

公开(公告)号：US20130280737A1

公开(公告)日：2013-10-24

申请号：US13919877

申请日：2013-06-17

Applicant: Li-Cor, Inc.

Inventor： Ahmed Bouzid ,  Chris Lesiak ,  Daniel W. Konz ,  David L. Franzen ,  William Biggs ,  Jon P. Anderson

IPC: G01N21/64

CPC classification number: C12Q1/6825 ,  G01J1/0403 ,  G01N21/62 ,  G01N21/6486 ,  G01N21/76 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/54373 ,  H04N1/1017 ,  H04N1/191 ,  H04N1/1933

Abstract: Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.

Abstract translation: 公开了用于精确地成像化学发光和其它发光的系统，装置和方法。 一种紧凑的平板扫描器，具有不透光的外壳，一个或多个线性电荷耦合器件（CCD）或互补金属氧化物半导体（CMOS）成像芯片的检测棒，以及高工作数值孔径（NA）光学器件密切扫描 在一个方向上的样品上，然后是相反的方向。 将两个或更多遍之间的每个像素位置（x，y）的强度读数的平均值或其他组合平均在一起以便补偿随时间变化的发光。 可以使用片上像素分档和多个时钟频率来最大化基于CCD的扫描仪中的信噪比。