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公开(公告)号：US10683483B2
公开(公告)日：2020-06-16
申请号：US16293618
申请日：2019-03-05
发明人： Jung-Hwa Oh , Jaehwan Ahn , Seokjoo Yoon , Heeyoung Yang , Jun-Ho Ahn , Mi-Sun Choi , Soojin Kim , Se-Myo Park , Hyoung-Yun Han
摘要： A microfabricated platform for mimicking the liver zonation and an evaluating method of zone-specific hepatotoxicity using the same is provided. The microfabricated platform for mimicking the liver zonation prepared according to the method of the present invention is divided into three zones of zone 1, zone 2 and zone 3 similarly to in vivo liver tissue and thus the zone-specific hepatotoxicity of a drug in the liver can be evaluated using the same. According to the present invention, the zone-specific hepatotoxicity results can be analyzed quantitatively by using image analysis, so that the platform of the present invention can be effectively used for in vitro screening of zone-specific hepatotoxicity.
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公开(公告)号：US11624087B2
公开(公告)日：2023-04-11
申请号：US16917135
申请日：2020-09-22
发明人： Jieon Lee , Woo-keun Kim , Sangwoo Lee , Seokjoo Yoon
IPC分类号： C12Q1/682
摘要： The present invention relates to a composition for detecting nucleic acid comprising duplex molecular beacon and graphene oxide and a colorimetric signal enhancement method of detecting nucleic acid using the same. According to the composition, kit and method for detecting nucleic acid of the present invention, a complex can be formed by adsorbing a single strand having a DNAzyme sequence dissociated from the conjugate of a duplex molecular beacon and a target nucleic acid to the graphene oxide surface, and separated, and a colorimetric signal amplified therefrom can be induced, so that a very low concentration of target nucleic acid can be detected with high efficiency and the target nucleic acid can be detected quickly and easily in seconds. Therefore, a new colorimetric target nucleic acid detection system capable of point of care testing (POCT) can be provided.
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公开(公告)号：US20240219333A1
公开(公告)日：2024-07-04
申请号：US18003757
申请日：2021-06-15
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人： Jung-Hwa Oh , Jaehwan Ahn , Seokjoo Yoon , Hyoung-Yun Han , Mi Young Son , Kwang Bo Jung , Cho Rok Jung , Janghwan Kim
IPC分类号： G01N27/04 , C12M1/26 , C12M1/34 , G01N33/483
CPC分类号： G01N27/041 , C12M33/04 , C12M33/12 , C12M41/40 , G01N33/4833
摘要： The present invention provides an impedance-based organoid evaluation system comprising an organoid deformation generating unit including a first tube and a plurality of second tubes having a diameter smaller than that of the first tube, connected to one end of the first tube or inserted therein; and an impedance measuring unit connected to the organoid deformation generating unit and including an impedance analyzer for measuring the impedance of the organoid, and evaluating the organoid from the impedance measured by the impedance measuring unit.
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公开(公告)号：US11166891B2
公开(公告)日：2021-11-09
申请号：US16562298
申请日：2019-09-05
发明人： Woo-Keun Kim , Sangwoo Lee , Seokjoo Yoon , Chul Min Park
IPC分类号： C07C43/215 , A61K8/33 , C07C43/285 , C07C41/30 , A23L33/10 , A61Q19/02
摘要： The present invention relates to a bis phenyl hexa triene derivative, a preparation method thereof and a composition for skin whitening comprising the same as an active ingredient. The said derivative inhibits the expression of tyrosinase, TRP 1 (tyrosinase-related protein 1), TRP 2 (tyrosinase-related protein 2) or MITF (microphthalmia-associated transcription factor) gene which produces a precursor necessary for the generation of melanin, suppresses the activity of tyrosinase, eventually inhibits the biosynthesis of melanin, is safe due to low cytotoxicity, and has less side effects and excellent antioxidative effect, so that it can be effectively used as a composition for skin whitening.
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公开(公告)号：US11814672B2
公开(公告)日：2023-11-14
申请号：US17006889
申请日：2020-08-30
发明人： Jieon Lee , Woo-keun Kim , Seokjoo Yoon , Bomi Shin
IPC分类号： C12Q1/6813
CPC分类号： C12Q1/6813 , C12Q2531/119 , C12Q2537/137 , C12Q2537/1373 , C12Q2600/178
摘要： The present invention provides a complex of LNA probe and graphene oxide, and a nucleic acid detection method using the same. In the present invention, LNA-containing molecular beacon is conjugated through covalent bonding with graphene oxide, a single strand of the molecular beacon binds to a target nucleic acid to form a complex, and the complex is separated from graphene oxide to induce a fluorescence signal. The molecular beacon and graphene oxide can be covalently bonded to minimize non-specific signals, and a LNA-added molecular beacon is designed in a double strand to detect a very low concentration of target nucleic acid with high sensitivity, as well as a fluorescent signal, and the multiple target nucleic acids can be detected simultaneously through diversification of the fluorescent signal to enable easy and accurate detection of a nucleic acid biomarker whose specific expression level is specifically changed according to diseases and disease progression.
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公开(公告)号：US20230093162A1
公开(公告)日：2023-03-23
申请号：US18070401
申请日：2022-11-28
发明人： Jung-Hwa Oh , Jaehwan Ahn , Seokjoo Yoon , Jun-Ho Ahn , Heeyoung Yang , Hyoung-Yun Han
摘要： The present invention relates to a fatty liver and liver fibrosis evaluation system based on impedance. The fatty liver and liver fibrosis evaluation system based on impedance provided in one aspect of the present invention uses 3-dimensional liver microtissues so that the fatty liver formation and the stiffness changes resulted from liver fibrosis induced by a test drug can be analyzed with non-invasive and highly reproducible manner.
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公开(公告)号：US20240148810A1
公开(公告)日：2024-05-09
申请号：US18279975
申请日：2021-03-19
发明人： Hyoung-Yun Han , Jung-Hwa Oh , Seokjoo Yoon , Se-Myo Park , Mi-Sun Choi , Soojin Kim
IPC分类号： A61K36/296 , A61K36/07 , A61K36/69 , A61P29/00 , A61P39/06
CPC分类号： A61K36/296 , A61K36/07 , A61K36/69 , A61P29/00 , A61P39/06 , A61K2236/331
摘要： The present invention relates to an anti-inflammatory composition comprising Epimedium koreanum Nakai, Polygala tenuifolia Willd, and Polyporus umbellatus Fries extracts or a mixture thereof as an active ingredient. The extracts and mixture prepared according to the present invention exhibit a high inhibitory effect against nitric oxide and a suppressive effect against the expression of iNOS and COX2 and thus can be advantageously used as an anti-inflammatory composition.
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