公开(公告)号：US10683483B2

公开(公告)日：2020-06-16

申请号：US16293618

申请日：2019-03-05

申请人： Korea Research Institute of Chemical Technology

发明人： Jung-Hwa Oh ,  Jaehwan Ahn ,  Seokjoo Yoon ,  Heeyoung Yang ,  Jun-Ho Ahn ,  Mi-Sun Choi ,  Soojin Kim ,  Se-Myo Park ,  Hyoung-Yun Han

IPC分类号： C12N5/071 ,  C12N5/00

摘要： A microfabricated platform for mimicking the liver zonation and an evaluating method of zone-specific hepatotoxicity using the same is provided. The microfabricated platform for mimicking the liver zonation prepared according to the method of the present invention is divided into three zones of zone 1, zone 2 and zone 3 similarly to in vivo liver tissue and thus the zone-specific hepatotoxicity of a drug in the liver can be evaluated using the same. According to the present invention, the zone-specific hepatotoxicity results can be analyzed quantitatively by using image analysis, so that the platform of the present invention can be effectively used for in vitro screening of zone-specific hepatotoxicity.

公开(公告)号：US20240148810A1

公开(公告)日：2024-05-09

申请号：US18279975

申请日：2021-03-19

申请人： Korea Research Institute of Chemical Technology

发明人： Hyoung-Yun Han ,  Jung-Hwa Oh ,  Seokjoo Yoon ,  Se-Myo Park ,  Mi-Sun Choi ,  Soojin Kim

IPC分类号： A61K36/296 ,  A61K36/07 ,  A61K36/69 ,  A61P29/00 ,  A61P39/06

CPC分类号： A61K36/296 ,  A61K36/07 ,  A61K36/69 ,  A61P29/00 ,  A61P39/06 ,  A61K2236/331

摘要： The present invention relates to an anti-inflammatory composition comprising Epimedium koreanum Nakai, Polygala tenuifolia Willd, and Polyporus umbellatus Fries extracts or a mixture thereof as an active ingredient. The extracts and mixture prepared according to the present invention exhibit a high inhibitory effect against nitric oxide and a suppressive effect against the expression of iNOS and COX2 and thus can be advantageously used as an anti-inflammatory composition.