摘要:
A p-aminophenol derivative having anti-inflammatory activity, represented by the formula ##STR1## wherein each of R.sup.1 and R.sup.2 is independently a hydrogen atom or a C.sub.1-6 acyl group; Ar is a pyrazine, pyrazine N-oxide, thiazole, benzene, pyridine, pyridazine, pyrimidine or triazine ring; R.sup.3 is a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy-carbonyl-C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a halogen atom or a carboxy-C.sub.1-6 alkyl group; A is a C.sub.1-6 alkylene group; and B is a C.sub.1-6 alkyl group, or a salt thereof.
摘要:
This invention provides thiazole derivative of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A are as defined above, and salts thereof. These compounds have particularly potent angiogenesis inhibiting activity.
摘要:
Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 is a lower alkyl group;R.sup.2 and R.sup.3 are each hydrogen or lower alkyl or R.sup.2 and R.sup.3 taken together may form --(CH.sub.2).sub.4 -- or --CH.dbd.CH--CH.dbd.CH--;.alpha. is a 5- or 6-membered heretoaromatic ring group containing 1 to 3 hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur, or a pyrazine-N-oxide ring, pyridazine-N-oxide ring or pyrimidine -N-oxide ring group, wherein each of these heteroaromatic ring groups may optionally have 1 to 3 substituents selected from the group consisting of a lower alkyl halogen, phenyl, lower alkoxycarbonyl, amino, lower alkoxy and hydroxy-lower alkyl, with the proviso that said 5- or 6-membered heteroaromatic ring group is not thiazolyl, isothiazolyl, pyridyl or 1,3,5-triazinyl group; or salts thereof. These compounds and salts thereof have anti-inflammatory activity and lipoxygenase-inhibitory activity.
摘要:
Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 is a lower alkyl group;R.sup.2 and R.sup.3 are each hydrogen or lower alkyl or R.sup.2 and R.sup.3 taken together may form --(CH.sub.2 (.sub.4)-- or --CH.dbd.CH--CH.dbd.CH--;.alpha. is a 5- or 6-membered heteroaromatic ring group containing 1 to 3 hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur, or a pyrazine-N-oxide ring, pyridazine-N-oxide ring or pyrimidine-N-oxide ring group, wherein each of these heteroaromatic ring groups may optionally have 1 to 3 substituents selected from the group consisting of a lower alkyl, halogen, phenyl, lower alkoxycarbonyl, amino, lower alkoxy and hydroxy-lower alkyl, with the proviso that said 5- or 6-membered heteroaromatic ring group is not thiazolyl, isothiazolyl, pyridyl or 1,3,5-triazinyl group; or salts thereof. These compounds and salts thereof have anti-inflammatory activity and lipoxygenase-inhibitory activity.
摘要:
Defects in a patterned substrate are detected by inspection with a charged particle beam inspection tool which generates an image of a portion of the patterned substrate and compares the image with a reference in order to identify any defects in the patterned substrate. Parameters of the tool are optimized to improve image uniformity and contrast, particularly voltage contrast. Prior to imaging an area of the substrate, the tool charges an area surrounding the image area to eliminate or reduce the effects caused by asymmetrical charging in the surrounding area. The tool alternates between charging the surrounding area and imaging the image area to produce a plurality of images of the image area, which are then averaged. The result is a highly uniform image with improved contrast for accurate defect detection.
摘要:
A roller-synchronized one-way clutch assembly includes a ring-shaped first retainer element, a ring-shaped second retainer element, a plurality of rollers and at least one spring extending between the first and second retainer elements. In the preferred embodiment, each of the first and second retainer elements is generally U-shaped and different in size and one of the first and second retainer elements is received in a U-shaped channel of the other. The first and second retainer elements are operatively coupled together such that they may move relative to each other in a circumferential direction over a predetermined angle. Alll of the rollers are movably supported by a retainer sub-assembly to provide a complete full phase function.
摘要:
A tester exercises a DUT with a repetitive signal pattern, supplying a trigger signal for each repetition. The waveform on a conductor of the DUT is to be acquired by repeatedly measuring voltage at each of a number of sample points following the trigger, using a charged-particle probe system having an integrator-filter loop for analyzing energy of secondary particles. Before measurement at a sample point, integrator is reset and the filter voltage needed to settle the loop for the sample point is set using a predictive scheme. When the measurement is made, the predicted filter voltage is summed with the integrator output voltage to produce the actual filter voltage. The integrator then measures the error between the predicted filter voltage and the actual filter voltage needed to settle the loop. The time needed to settle the loop is thereby minimized. Various predictive schemes can be used. An adaptive predictive scheme uses the error measured by the integrator to update the filter voltage prediction for the next measurement at the same sample point. The predicted filter voltage can be a previous measurement or an average of previous measurements taken at that sample point or an average of previous measurements taken over some time interval or a value determined by any other desired predictive scheme.
摘要:
An apparatus for increasing electric conductivity to a wafer substrate, when exposed to electron beam irradiation, is disclosed. More specifically, a methodology to breakdown the insulating layer on wafer backside is provided to significantly reduce the damage on the wafer backside while proceeding with the grounding process.
摘要:
Methods and apparatus, including computer program products, implementing and using techniques for open-loop waveform acquisition. In general, in one aspect, the invention provides a method for open-loop waveform acquisition. The method includes acquiring an S-curve of an acquisition loop of an electron-beam probe system. The S-curve represents a response of the acquisition loop to changes of potential differences between the acquisition loop and a device under test. The method includes calibrating the acquisition loop to obtain a linear region in the acquired S-curve and using the linear portion of the acquired S-curve to calculate voltage at a probe point of the device under test.
摘要:
A toner level sensor for detecting the presence or absence or the level of residual amount of the toner of an electronic copier or the like. In order to secure stable operation regardless of changes of external environmental conditions such as temperature and humidity, a pair of transformers are provided with primary coils and secondary coils respectively wound on magnetic cores having a magnetic gap. When a magnetic member is present in the vicinity of a magnetic gap, the phases of the outputs of the secondary coils are opposite to each other, so that the differential output of the secondary coils is phase detected to determine the presence or absence of the residual toner amount or the level of residual amount.