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公开(公告)号：US5756875A
公开(公告)日：1998-05-26
申请号：US423328
申请日：1995-04-14
CPC分类号： G01N29/30 , A61B8/587 , G01N29/0609
摘要： Phantoms for testing and measuring the performance of ultrasonic imaging systems have regions of precisely controlled scattering or echogenicity which contain sub-resolvable scatterers. The regions are precisely positioned so as to define patterns which form images from which the performance of the ultrasonic imaging system can be evaluated to assure the quality of the images. The phantoms can reveal the combined influences of all the stages in the imaging chain in terms of modulation transfer function and resolution limits as well as other artifacts and defects in the system such as aliasing and degraded frequency response which cannot be evaluated with conventional ultrasound phantoms. The subresolution scattering regions may be formed by printing them on a thin film sheet or substrate using photo lithography, electrostatic xerographic printing or etching; the toner particles or deposited material forming the scatters being sub-resolvable in size. Half-tone masks, such as blue noise masks, may be used to produce regions of precisely controlled sub-resolvable scatters to be used for grey scale evaluation of the imaging system by producing speckle images of different echogenicity. The thin film sheets are thinner than the thickness of the ultrasonic beam and enable propagation of the beam in the plane of the sheets to the patterns which may be located at different depths. The thin film sheets may be displaced, as by being vibrated. The sheets may be made of piezoelectric material having electrodes across which varying electrical signals are applied to displace the sheets thereby simulating movement of objects for Doppler measurements.
摘要翻译： 用于测试和测量超声成像系统性能的幻影具有精确控制的散射或回波反射的区域，其包含可分解的散射体。 这些区域被精确定位以便限定形成图像的图案，从该图像可以评估超声成像系统的性能，以确保图像的质量。 幻影可以显示调制传递函数和分辨率极限以及系统中的其他伪像和缺陷等成像链中的所有阶段的综合影响，例如不能用常规超声模型评估的混叠和降低的频率响应。 可以通过使用光刻，静电静电印刷或蚀刻将它们印刷在薄膜片或衬底上来形成亚分散散射区域; 形成散射的调色剂颗粒或沉积材料的尺寸是可分解的。 可以使用诸如蓝色噪声掩模的半色调蒙版来产生精确控制的可分解散射的区域，以通过产生不同回波特征的散斑图像来用于成像系统的灰度评估。 薄膜片比超声波束的厚度薄，并且能够将片材的平面中的光束传播到可以位于不同深度的图案。 薄膜片可以通过振动而移位。 片材可以由具有电极的压电材料制成，跨越其上施加变化的电信号以移位片材，从而模拟用于多普勒测量的物体的移动。
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公开(公告)号：US06720766B2
公开(公告)日：2004-04-13
申请号：US10345988
申请日：2003-01-17
IPC分类号： G01V300
CPC分类号： G01N29/30 , A61B6/583 , A61B8/587 , G01N29/0609 , G01N29/0672
摘要： Phantoms for testing and measuring the performance of magnetic resonance imaging (MRI) and x-ray computed tomography (CT) imaging systems have regions of precisely controlled magnetic resonance and x-ray absorption imaging properties. These regions contain subresolvable regions, or distinct micro regions, with pre-selected magnetic resonance or x-ray absorption properties, called scatterers. The regions are precisely positioned so as to define patterns which form images from which the performance of the imaging system can be evaluated to assure the quality of the images. The phantoms can reveal the combined influences of all the stages in the imaging chain in terms of modulation transfer function and resolution limits as well as other artifacts and defects in the system such as aliasing and degraded spatial frequency response which cannot be evaluated with conventional phantoms. The subresolution scattering regions may be formed by printing them on a thin film sheet or substrate using photo lithography, electrostatic xerographic printing or etching; the toner particles or deposited material forming the scatterers being sub-resolvable in size. Half-tone masks, such as blue noise masks, may be used to produce regions of precisely controlled sub-resolvable scatterers to be used for grey scale evaluation of the imaging system by producing images of different image density. The thin film sheets are thinner than the thickness of the x-ray CT beam or the MRI slice thickness excitation. The thin film sheets may be displaced, as by being vibrated. The sheets may be made of piezoelectric material having electrodes across which varying electrical signals are applied to displace the sheets thereby simulating movement of objects for Doppler measurements. Similar phantoms are used for testing and measuring the performance of ultrasonic imaging systems.
摘要翻译： 用于测试和测量磁共振成像（MRI）和X射线计算机断层摄影（CT）成像系统的性能的幽灵具有精确控制的磁共振和X射线吸收成像特性的区域。 这些区域包含称为散射体的具有预选磁共振或X射线吸收特性的可分解区域或不同的微区域。 这些区域被精确定位以便限定形成图像的图案，从该图像可以评估成像系统的性能以确保图像的质量。 幻影可以显示调制传递函数和分辨率极限以及系统中其他伪像和缺陷等成像链中所有阶段的综合影响，如混叠和降级的空间频率响应，无法用常规幻影进行评估。 可以通过使用光刻，静电静电印刷或蚀刻将它们印刷在薄膜片或衬底上来形成亚分散散射区域; 形成散射体的调色剂颗粒或沉积材料的尺寸是可分解的。 可以使用诸如蓝色噪声掩模的半色调掩模来产生精确控制的可分解散射体的区域，以通过产生不同图像密度的图像来用于成像系统的灰度评估。 薄膜片比X射线CT束的厚度或MRI切片厚度激发薄。 薄膜片可以通过振动而移位。 片材可以由具有电极的压电材料制成，跨越其上施加变化的电信号以移位片材，从而模拟用于多普勒测量的物体的移动。 类似的幻影用于测试和测量超声成像系统的性能。
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3.发明申请公开(公告)号：US20140148697A1
公开(公告)日：2014-05-29
申请号：US14118461
申请日：2012-05-17
CPC分类号： A61B8/4483 , A61B8/08 , A61B8/461 , A61B8/485 , A61B8/488 , A61B8/5223 , F04C2270/0421
摘要： Using a modified ultrasound device, crawling waves are applied to the liver over a range of shear wave frequencies. Dispersion measurements are obtained that reflect tissue viscosity and these correlate with the degree of steatosis. A device for the process has an actuator on either side of the ultrasound transducer to apply shear waves, which interfere to produce the crawling waves.
摘要翻译： 使用改进的超声波装置，在一定范围的剪切波频率上将爬行波施加到肝脏。 获得反映组织粘度的分散度测量，并且这些与脂肪变性程度相关。 用于该过程的装置具有在超声换能器的任一侧上的致动器以施加剪切波，其干扰产生爬行波。
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4.发明授权Real time visualization of shear wave propagation in soft materials with sonoelastography 有权用弹性成像技术实现软材料剪切波传播的实时可视化公开(公告)号：US07444875B1
公开(公告)日：2008-11-04
申请号：US11356472
申请日：2006-02-17
申请人： Zhe Wu , Kevin J. Parker
发明人： Zhe Wu , Kevin J. Parker
CPC分类号： A61B8/08 , A61B5/0051 , A61B5/7239 , A61B8/485 , A61B8/587 , G01S7/52042 , G01S15/8979
摘要： An ultrasound system visualizes shear wave propagation in real time by slowing down the propagation of the shear wave as seen by the ultrasound probe. The shear wave source propagates shear waves into the medium at a frequency ω. The ultrasound probe is vibrated by a vibrator at the frequency ω−Δω, where Δω is much smaller than ω. The wave propagation as seen by the ultrasound probe is slowed down by a factor Δω/ω. An appropriate value of Δω allows real-time visualization of the wave propagation. Variations include electronically producing a virtual vibration and the use of multiple shear wave sources.
摘要翻译： 超声系统通过减慢超声波探头所见的剪切波的传播来实时显示剪切波传播。 剪切波源以频率ω将剪切波传播到介质中。 超声波探头由ω-Deltaomega的振动器振动，其中Deltaomega远小于ω。 超声探头所见的波传播速度降低了因子Deltaomega /ω。 Deltaomega的适当值允许波形传播的实时可视化。 变化包括电子地产生虚拟振动和使用多个剪切波源。
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5.发明授权Method and apparatus for halftone rendering of a gray image using a blue noise mask 失效使用蓝色噪声掩模对灰度图像进行半色调渲染的方法和装置
公开(公告)号：US5543941A
公开(公告)日：1996-08-06
申请号：US251140
申请日：1994-05-31
申请人： Kevin J. Parker , Theophano Mitsa
发明人： Kevin J. Parker , Theophano Mitsa
CPC分类号： H04N1/40075 , G06T3/40 , G06T3/4084 , H04N1/4051 , H04N1/4105
摘要： A method of and system for rendering a halftone image of a gray scale image by utilizing a pixel-by-pixel comparison of the gray scale image against a blue noise mask is disclosed in which the gray scale image is scanned on a pixel-by-pixel basis and compared on a pixel-by-pixel basis to an array of corresponding data points contained in a blue noise mask stored in a PROM or computer memory in order to produce the desired halftoned image. Both digital and optically implemented halftone methods are disclosed. Application specific modifications of the blue noise mask as well as its use for producing halftoned color images are also disclosed.
摘要翻译： 公开了通过利用灰度图像与蓝色噪声掩模的逐像素比较来渲染灰度图像的半色调图像的方法和系统，其中灰度图像被逐个扫描， 像素为基础，并且在逐个像素的基础上与包含在存储在PROM或计算机存储器中的蓝色噪声掩码中的对应数据点的阵列进行比较，以便产生所需的半色调图像。 公开了数字和光学实现的半色调方法。 还公开了蓝色噪声掩模的特定应用以及其用于产生半色调彩色图像的应用。
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公开(公告)号：US5479932A
公开(公告)日：1996-01-02
申请号：US106553
申请日：1993-08-16
IPC分类号： A61B5/0205 , A61B5/11 , A61B5/113
CPC分类号： A61B5/6892 , A61B5/0205 , A61B5/1104 , A61B5/113 , A61B2503/04
摘要： Apparatus for effectively and accurately monitoring the health of an infant is realized by simultaneously detecting large motor movement, heart beat and respiration of the infant, and sounding an alarm when an exacting combination of all three signals is not sensed. This integrated combination effectively eliminates false alarms inherent in prior art monitors. Preferably, a passive sensor is placed under, but not in direct contact with, a child for generating a voltage in proportion to the movement of the child. This signal is amplified, filtered and analyzed for the presence of large motor movement, heart beat and respiration. An alarm signal is sounded when all three are not present in the signal.
摘要翻译： 用于有效和准确地监测婴儿健康的装置通过同时检测婴儿的大的马达运动，心跳和呼吸，并且当没有感测到所有三个信号的精确组合时发出警报来实现。 这种集成组合有效地消除了现有技术监视器固有的假警报。 优选地，将无源传感器放置在与儿童的直接接触下方，而不是与儿童的运动成比例地产生电压。 该信号被放大，过滤和分析是否存在大的运动，心跳和呼吸。 当信号中不存在三个信号时，发出报警信号。
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7.发明授权公开(公告)号：US10073176B2
公开(公告)日：2018-09-11
申请号：US14870647
申请日：2015-09-30
申请人： Kevin J. Parker , Shujie Chen
发明人： Kevin J. Parker , Shujie Chen
CPC分类号： G01S15/8977 , G01S7/52077
摘要： Systems and methods of pulse-echo imaging using stabilized symmetric pulses are described. The systems and methods are based on the development of a class of symmetric, i.e., two sided, functions that can be designed and utilized as stabilized pulses. Stabilized pulses are pulses having stable inverse filters, and have previously only been established for asymmetric functions. The systems and methods described herein can be used for super-resolution pulse-echo imaging, for example super-resolution ultrasound imaging.
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8.发明申请Superresolution Imaging Of Scatterers In Pulse-Echo Imaging With Symmetric Stabilized Pulses 审中-公开用对称稳定脉冲进行脉冲回波成像的散射体超分辨成像公开(公告)号：US20160091605A1
公开(公告)日：2016-03-31
申请号：US14870647
申请日：2015-09-30
申请人： Kevin J. Parker , Shujie Chen
发明人： Kevin J. Parker , Shujie Chen
CPC分类号： G01S15/8977 , G01S7/52077
摘要： Systems and methods of pulse-echo imaging using stabilized symmetric pulses are described. The systems and methods are based on the development of a class of symmetric, i.e., two sided, functions that can be designed and utilized as stabilized pulses. Stabilized pulses are pulses having stable inverse filters, and have previously only been established for asymmetric functions. The systems and methods described herein can be used for super-resolution pulse-echo imaging, for example super-resolution ultrasound imaging.
摘要翻译： 描述使用稳定对称脉冲的脉冲回波成像的系统和方法。 系统和方法基于开发可以被设计和用作稳定脉冲的一类对称，即双面功能。 稳定脉冲是具有稳定的反向滤波器的脉冲，并且之前仅为非对称功能建立。 本文所述的系统和方法可用于超分辨率脉冲回波成像，例如超分辨率超声成像。
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公开(公告)号：US06169817A
公开(公告)日：2001-01-02
申请号：US09185514
申请日：1998-11-04
IPC分类号： G06K936
CPC分类号： G06T7/0012 , G06T7/11 , G06T7/143 , G06T7/215 , G06T2207/10088 , G06T2207/30008
摘要： From raw image data obtained through magnetic resonance imaging or the like, an object is reconstructed and visualized in four dimensions (both space and time) by first dividing the first image in the sequence of images into regions through statistical estimation of the mean value and variance of the image data and joining of picture elements (voxels) that are sufficiently similar and then extrapolating the regions to the remainder of the images by using known motion characteristics of components of the image (e.g., spring constants of muscles and tendons) to estimate the rigid and deformational motion of each region from image to image. The object and its regions can be rendered and interacted with in a four-dimensional virtual reality environment.
摘要翻译： 从通过磁共振成像等获得的原始图像数据，通过首先将图像序列中的第一图像划分为区域，通过统计估计平均值和方差来重建和可视化四维空间（时间和空间） 的图像数据和图像元素（体素）的连接，并且然后通过使用图像的分量的已知运动特性（例如，肌肉和肌腱的弹簧常数）将区域外推到剩余的图像来估计 每个区域从图像到图像的刚性和变形运动。 对象及其区域可以在四维虚拟现实环境中渲染和交互。
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公开(公告)号：US5776496A
公开(公告)日：1998-07-07
申请号：US384193
申请日：1995-02-06
CPC分类号： A61K49/0461 , A61K49/223 , Y10S514/951 , Y10S514/965
摘要： This invention relates to the preparation, composition and applications of suspensions of ultra-small, substantially non-aggregated, non-crystalline particles of predetermined uniform size which, when suspended in a liquid, contain entrapped gaseous bubbles. These gaseous bubble particles are prepared by simultaneous co-precipitation of two compounds. In accordance with the present invention, the two compounds chosen for co-precipitation are such that one is substantially more soluble than the other in a given vehicle. When this vehicle is used for washing the co-precipitated particles, part of the soluble material is dissolved leaving a porous matrix. The porous particles then are dried and stored. The porous particles, which can be resuspended immediately prior to use, contain entrapped gas in the evacuated crevices or pores which is not displaced for a period of time because of surface tension of the suspending vehicle. These ultrasmall, substantially non-aggregated porous particles therefore can be used to advantage as ultrasound contrast agents as well as other applications.
摘要翻译： 本发明涉及预定均匀尺寸的超小型，基本上非聚集的非结晶颗粒的悬浮液的制备，组成和应用，当悬浮在液体中时，其含有截留的气泡。 这些气泡颗粒通过两种化合物的同时共沉淀制备。 根据本发明，选择用于共沉淀的两种化合物使得在给定的载体中一种化合物比其它化合物更可溶。 当该载体用于洗涤共沉淀颗粒时，溶解的部分溶解物留下多孔基体。 然后将多孔颗粒干燥并储存。 可以在使用前立即重新悬浮的多孔颗粒在被抽空的缝隙中包含夹带气体，由于悬浮车辆的表面张力而不被移位一段时间。 因此，这些超小型，基本上非聚集的多孔颗粒可以用作超声造影剂以及其它应用。
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