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公开(公告)号：US20180237851A1
公开(公告)日：2018-08-23
申请号：US15953822
申请日：2018-04-16
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
IPC分类号： C12Q1/6874 , C12Q1/689 , C12N15/10 , G06F19/22
CPC分类号： C12Q1/6874 , C12N15/1065 , C12Q1/6869 , C12Q1/689 , C12Q2600/166 , G16B30/00 , C12Q2545/101
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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公开(公告)号：US20240344111A1
公开(公告)日：2024-10-17
申请号：US18527138
申请日：2023-12-01
申请人： Karius, Inc.
IPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q1/6895 , G06F17/18
CPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q1/6895 , G06F17/18 , C12Q2565/102
摘要： This disclosure provides methods, compositions and kits for determining if nucleic acids detected in a sample such as a clinical sample are derived from contaminant pathogens or clinically-relevant pathogens.
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公开(公告)号：US11692224B2
公开(公告)日：2023-07-04
申请号：US17355882
申请日：2021-06-23
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
IPC分类号： C12Q1/68 , C12Q1/6874 , G16B30/00 , C12Q1/6869 , G16B30/10 , C12N15/10 , C12Q1/689
CPC分类号： C12Q1/6874 , C12N15/1065 , C12Q1/689 , C12Q1/6869 , G16B30/00 , G16B30/10 , C12Q2600/166 , C12Q1/6869 , C12Q2545/101
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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公开(公告)号：US11078532B2
公开(公告)日：2021-08-03
申请号：US15953822
申请日：2018-04-16
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
IPC分类号： C12Q1/68 , C12Q1/6874 , G16B30/00 , C12Q1/6869 , C12N15/10 , C12Q1/689
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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公开(公告)号：US20240309427A1
公开(公告)日：2024-09-19
申请号：US18674513
申请日：2024-05-24
申请人： Karius, Inc.
IPC分类号： C12Q1/6806 , C12N15/10 , C12Q1/6848 , C12Q1/6869 , C12Q1/6876
CPC分类号： C12Q1/6806 , C12N15/10 , C12N15/1003 , C12Q1/6848 , C12Q1/6869 , C12Q1/6876 , C12Q2523/313
摘要： This disclosure provides methods that are useful for reducing or inactivating contaminant nucleic acids.
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公开(公告)号：US20210324467A1
公开(公告)日：2021-10-21
申请号：US17355882
申请日：2021-06-23
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
IPC分类号： C12Q1/6874 , G16B30/00 , C12Q1/6869 , G16B30/10 , C12N15/10 , C12Q1/689
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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公开(公告)号：US20170275691A1
公开(公告)日：2017-09-28
申请号：US15469474
申请日：2017-03-24
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
CPC分类号： C12Q1/6874 , C12N15/1065 , C12Q1/6869 , C12Q1/689 , C12Q2600/166 , G06F19/22 , C12Q2545/101
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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公开(公告)号：US20240043923A1
公开(公告)日：2024-02-08
申请号：US18313716
申请日：2023-05-08
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
IPC分类号： C12Q1/6874 , G16B30/00 , C12Q1/6869 , G16B30/10 , C12N15/10 , C12Q1/689
CPC分类号： C12Q1/6874 , G16B30/00 , C12Q1/6869 , G16B30/10 , C12N15/1065 , C12Q1/689 , C12Q2600/166
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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公开(公告)号：US11674167B2
公开(公告)日：2023-06-13
申请号：US16884343
申请日：2020-05-27
申请人： KARIUS, INC.
IPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q1/6895 , G06F17/18
CPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q1/6895 , G06F17/18 , C12Q2565/102
摘要： This disclosure provides methods, compositions and kits for determining if nucleic acids detected in a sample such as a clinical sample are derived from contaminant pathogens or clinically-relevant pathogens.
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公开(公告)号：US09976181B2
公开(公告)日：2018-05-22
申请号：US15469474
申请日：2017-03-24
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
CPC分类号： C12Q1/6874 , C12N15/1065 , C12Q1/6869 , C12Q1/689 , C12Q2600/166 , G06F19/22 , C12Q2545/101
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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