公开(公告)号：US10570365B2

公开(公告)日：2020-02-25

申请号：US15850320

申请日：2017-12-21

Applicant: Kaohsiung Medical University

Inventor： Che-Hsin Lin ,  Yao-Hsien Wang ,  Chung-Hwan Chen ,  Je-Ken Chang ,  Mei-Ling Ho

IPC: C12M1/00 ,  G01N1/28 ,  B04B13/00 ,  B04B5/10 ,  G01N35/00 ,  G01N35/10 ,  C12M1/33 ,  B01L3/02 ,  B01L9/00 ,  G01N1/40 ,  B04B11/04

Abstract: An automatic cell isolation and collection system for sorting out target cells from a sample includes a crush module, a centrifuge module, a transport module, and a control unit. The centrifuge module includes centrifuge tubes and a magnetic mechanism providing a magnetically attractive force to at least one of the centrifuge tubes. The control unit electrically communicates with the crush module, the centrifuge module, and the transport module, and controls operation of the crush module, transport of the sample via the transport module after the sample is crushed by the crush module, centrifugation of the centrifuge module, and operation of the magnetic mechanism for providing the magnetically attractive force.

公开(公告)号：US20180328824A1

公开(公告)日：2018-11-15

申请号：US15850320

申请日：2017-12-21

Applicant: Kaohsiung Medical University

Inventor： Che-Hsin Lin ,  Yao-Hsien Wang ,  Chung-Hwan Chen ,  Je-Ken Chang ,  Mei-Ling Ho

IPC: G01N1/40 ,  B01L3/02 ,  B01L9/00

Abstract: An automatic cell isolation and collection system for sorting out target cells from a sample includes a crush module, a centrifuge module, a transport module, and a control unit. The centrifuge module includes centrifuge tubes and a magnetic mechanism providing a magnetically attractive force to at least one of the centrifuge tubes. The control unit electrically communicates with the crush module, the centrifuge module, and the transport module, and controls operation of the crush module, transport of the sample via the transport module after the sample is crushed by the crush module, centrifugation of the centrifuge module, and operation of the magnetic mechanism for providing the magnetically attractive force.

公开(公告)号：US20150157762A1

公开(公告)日：2015-06-11

申请号：US14614718

申请日：2015-02-05

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Mei-Ling Ho ,  Je-Ken Chang ,  Rajalakshmanan Eswaramoorthy ,  Shun-Cheng Wu ,  Yao-Hsien Wang

IPC: A61L27/18 ,  A61L27/56 ,  A61L27/54

CPC classification number: A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/02 ,  C08G63/912 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2207/10 ,  C08J2367/04 ,  C12N5/0667 ,  C12N2500/42 ,  C12N2501/999 ,  C12N2533/40 ,  C12N2537/10 ,  Y10T428/2982

Abstract: A method for bone regeneration which comprises administering a short term release composition into a bone area of a subject in need thereof, wherein the composition comprises a poly(lactic-co-glycolic acid) cross-linked alendronate (PLGA-ALN), wherein the composition releases the alendronate into the bone area, wherein the bone tissue of the bone area is exposed in situ to a therapeutically effective amount of the alendronate over 9 days.

Abstract translation: 一种用于骨再生的方法，其包括将短期释放组合物施用到有需要的受试者的骨区域中，其中所述组合物包含交联的聚（乳酸 - 共 - 乙醇酸）阿仑膦酸钠（PLGA-ALN），其中 组合物将阿仑膦酸盐释放到骨区域中，其中骨区域的骨组织在9天内原位暴露于治疗有效量的阿仑膦酸盐。

公开(公告)号：US20200033232A1

公开(公告)日：2020-01-30

申请号：US16337399

申请日：2016-09-29

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Che-Hsin Lin ,  Yao-Hsien Wang ,  Chung-Hwan Chen ,  Je-Ken Chang ,  Mei-Ling Ho

IPC: G01N1/04 ,  G01N1/28

Abstract: Provided is a device for rapidly isolating cells from tissue, comprising: a stirring and cutting member, having a rotary cutting tool, wherein same is driven by a motor so as to rotate to stir and cut tissue, and can inject digestive enzymes to accelerate decomposition of the tissue; and double-layered nested cups comprising an inner cup and an outer cup, used for accommodating and filtering solution of required cells, wherein a filter device of the inner cup screens out the required cells, and the outer cup collects the filtered solution.

公开(公告)号：US09889225B2

公开(公告)日：2018-02-13

申请号：US14614718

申请日：2015-02-05

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Mei-Ling Ho ,  Je-Ken Chang ,  Rajalakshmanan Eswaramoorthy ,  Shun-Cheng Wu ,  Yao-Hsien Wang

IPC: A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  C08J9/26 ,  C08G63/91 ,  C12N5/0775

CPC classification number: A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/02 ,  C08G63/912 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2207/10 ,  C08J2367/04 ,  C12N5/0667 ,  C12N2500/42 ,  C12N2501/999 ,  C12N2533/40 ,  C12N2537/10 ,  Y10T428/2982

Abstract: A method for bone regeneration which comprises administering a short term release composition into a bone area of a subject in need thereof, wherein the composition comprises a poly(lactic-co-glycolic acid) cross-linked alendronate (PLGA-ALN), wherein the composition releases the alendronate into the bone area, wherein the bone tissue of the bone area is exposed in situ to a therapeutically effective amount of the alendronate over 9 days.