公开(公告)号：US20240354599A1

公开(公告)日：2024-10-24

申请号：US18304594

申请日：2023-04-21

Applicant: KAOHSIUNG MEDICAL UNIVERSITY ,  National Sun Yat-Sen University

Inventor： Hao-Wei Chen ,  Chung-Yao Kao ,  Jung-Ting Lee ,  Yu-Chen Chen

IPC: G06N5/022 ,  A61B5/20 ,  G16H50/30

CPC classification number: G06N5/022 ,  A61B5/201 ,  G16H50/30

Abstract: A method for determining a probability of a kidney stone in a subject being a uric-acid (UA) stone includes steps of: establishing, by using a machine learning algorithm, a prediction model based on a plurality of training data sets that are related to a plurality of patients, each of the plurality of training data sets at least including an estimated glomerular filtration rate (eGFR) and a value of urine pH; and feeding an input variable set into the prediction model so as to obtain the probability of the kidney stone in the subject being a UA stone. The input variable set is related to the subject and including an eGFR and a value of urine pH of the subject.

公开(公告)号：US20230144230A1

公开(公告)日：2023-05-11

申请号：US17832996

申请日：2022-06-06

Applicant: Kaohsiung Medical University ,  NATIONAL YANG MING CHIAO TUNG UNIVERSITY

Inventor： Chia-Hsin CHEN ,  Li-Wei KO ,  Yi-Jen CHEN ,  Yi-Chen LU ,  Lo-Fan CHANG

IPC: A61H1/02

CPC classification number: A61H1/02 ,  A61H2230/105 ,  A61H2201/501 ,  A61H2201/1207

Abstract: A rehabilitation system based on brainwave control includes a rehabilitation device, a brainwave device and a control unit. The rehabilitation device includes a power unit and a rehabilitation unit. The control unit is coupled with the rehabilitation device and the brainwave device. In a state where the power unit provides the predetermined output to control the rehabilitation unit to drive the rehabilitation part to move, the control unit receives the brainwave signal and determines whether the brainwave signal is lower than a stimulation threshold. In a state where the brainwave signal is lower than the stimulation threshold, the control unit sends an adjustment signal to control the power unit to adjust the predetermined output to drive the rehabilitation unit to move.

公开(公告)号：US11344548B2

公开(公告)日：2022-05-31

申请号：US15557360

申请日：2015-10-08

Applicant: KAOHSIUNG MEDICAL UNIVERSITY ,  Alice Y Huang

Inventor： Hui-Ting Chen ,  Kuang-Chan Hsieh ,  Chai-Lin Kao ,  Je-Ken Chang ,  Mei-Ling Ho

IPC: A61K31/505 ,  A61K47/64 ,  A61K31/40 ,  A61K31/44 ,  A61K31/47 ,  A61P19/10 ,  A61P19/08

Abstract: A method for treating low bone mineral density associated with osteopenia, osteoporosis, and other diseases is disclosed. The method comprises administrating a composition comprising a 3,5-dihydroxypentanoic acid derivative according to Formula I to a mammal. A compound of 3,5-dihydroxypentanoic acid derivative having a structure according to Formula I or Formula II is also disclosed.

公开(公告)号：US11111184B2

公开(公告)日：2021-09-07

申请号：US15780643

申请日：2016-12-02

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Chih-Kuang Wang ,  Mei-Ling Ho ,  Li-Cheng Pan ,  Yin-Chih Fu ,  Chung-Hwan Chen ,  Je-Ken Chang

IPC: C04B35/64 ,  B22F1/00 ,  B22F3/10 ,  C04B35/634 ,  B33Y10/00 ,  B29C64/165 ,  C04B111/00 ,  B29C67/00 ,  C04B35/56 ,  C04B35/58 ,  C04B35/626 ,  C04B35/486 ,  C03B19/06 ,  C04B35/111 ,  C04B35/18 ,  C04B35/632 ,  B22F10/10 ,  B33Y70/00 ,  B28B1/00 ,  C04B35/447 ,  C04B38/00

Abstract: The present invention provides a method of additive manufacturing a 3D-printed article, comprising: (a) printing and depositing one or more layers of a slurry by using a 3D printer, wherein the slurry comprises a ceramic powder composition; (b) further injecting an oil around the one or more layers of slurry, wherein the height of the injected oil is lower than the height of the slurry; (c) repeating steps (a) and (b) until a main body with desired geometric shape is obtained; and (d) sintering the main body by heating to obtain the 3D-printed article wherein the temperature of a printing carrier of the 3D printer is from 30 to 80° C.

公开(公告)号：US20210162074A1

公开(公告)日：2021-06-03

申请号：US17168873

申请日：2021-02-05

Applicant: Kaohsiung Medical University

Inventor： Chau-Zen Wang ,  Chung-Hwan Chen ,  Liang-Yin Chou ,  Yu Chou ,  Mei-Ling Ho ,  Yi-Hsiung Lin

IPC: A61K48/00 ,  A61P19/10 ,  A61K38/45 ,  A61K9/127 ,  A61K9/00 ,  C12N15/86 ,  C12N7/00 ,  A61P19/00

Abstract: The present invention relates to a method for treating or alleviating an osteoporosis in a subject. The method comprises steps of identifying the subject having the osteoporosis, and administering to the subject an effective amount of a composition that increases a level of Discoidin Domain Receptor 1 (DDR1) protein in the subject.

公开(公告)号：US10668122B2

公开(公告)日：2020-06-02

申请号：US15596799

申请日：2017-05-16

Applicant: Metal Industries Research & Development Centre ,  Kaohsiung Medical University

Inventor： Pei-Jung Lien ,  Chuan-Chia Sun ,  Tzu-Chen Kuo ,  Sheng-Chung Yang ,  Yang-Chang Wu ,  Fang-Rong Chang ,  Tusty-Jiuan Hsieh ,  Yi-Hong Tsai ,  Ying-Chi Du

IPC: A61K36/58 ,  A61K36/00 ,  A23L33/105

Abstract: The Toona sinensis extract of the present invention is prepared using supercritical fluid technique, wherein the method includes steps of: (a) drying the leaves of T. sinensis; (b) pulverizing the leaves as particles; and (c) extracting the particles with supercritical carbon dioxide to obtain the T. sinensis extract. This supercritical T. sinensis extract not only can decrease blood sugar level, but also promotes lipid degradation, inhibits the formation of huge lipid droplet and improves the metabolic symptoms. Accordingly, the T. sinensis extract further is able to be prepared as food supplement and pharmaceuticals.

公开(公告)号：US10570365B2

公开(公告)日：2020-02-25

申请号：US15850320

申请日：2017-12-21

Applicant: Kaohsiung Medical University

Inventor： Che-Hsin Lin ,  Yao-Hsien Wang ,  Chung-Hwan Chen ,  Je-Ken Chang ,  Mei-Ling Ho

IPC: C12M1/00 ,  G01N1/28 ,  B04B13/00 ,  B04B5/10 ,  G01N35/00 ,  G01N35/10 ,  C12M1/33 ,  B01L3/02 ,  B01L9/00 ,  G01N1/40 ,  B04B11/04

Abstract: An automatic cell isolation and collection system for sorting out target cells from a sample includes a crush module, a centrifuge module, a transport module, and a control unit. The centrifuge module includes centrifuge tubes and a magnetic mechanism providing a magnetically attractive force to at least one of the centrifuge tubes. The control unit electrically communicates with the crush module, the centrifuge module, and the transport module, and controls operation of the crush module, transport of the sample via the transport module after the sample is crushed by the crush module, centrifugation of the centrifuge module, and operation of the magnetic mechanism for providing the magnetically attractive force.

公开(公告)号：US20190388119A1

公开(公告)日：2019-12-26

申请号：US16471182

申请日：2016-12-19

Applicant: Kaohsiung Medical University

Inventor： Pei-hsi CHOU ,  Cheng-chang LU ,  Yu-chuan LIN

IPC: A61B17/34 ,  A61B17/04

Abstract: Disclosed is an arthroscopic cannula to solve the problem of more wounds being created due to the use of a plurality of cannulas in a conventional arthroscopic surgery. The arthroscopic cannula includes a cannula body, a spacer provided inside the cannula body and extending axially along the cannula body to divide an internal space of the cannula body into a first chamber and a second chamber, and a joint connected to one end of the cannula body. The interior of the joint intercommunicates with the first chamber and the second chamber.

公开(公告)号：US20190203265A1

公开(公告)日：2019-07-04

申请号：US16355852

申请日：2019-03-18

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Ming-Tsang Wu ,  Deng-Chyang Wu ,  Hung-Ju Su ,  Shah-Hwa Chou ,  Jie-Len Huang ,  Yu-Kuei Chen ,  Chun-Chieh Wu

IPC: C12Q1/686 ,  C12Q1/6876

CPC classification number: C12Q1/686 ,  C12Q1/6876 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/16

Abstract: The present invention provides a method for determining a survival rate and prognosis state and providing care for a patient having esophageal carcinoma, comprising: (a) providing a tissue sample from the patient; (b) measuring an expression level of a plurality of target genes comprising peptidase inhibitor 3 (PI3) and CD14 in the tissue sample from the patient using reagents specific for a gene product of the plurality of target genes that are selected from the group consisting of probes, primers, antibodies, and antibody fragments, wherein the expression level is measured by RNA expression or protein expression; (c) comparing the expression level of the plurality of target genes to a predetermined threshold indicative of a survival rate and prognosis state for the patient; and (d) providing care for the patient when the survival rate and prognosis state is worse, wherein the care is advising the patent to reduce the time between return visit or to add adjuvant chemotherapy after surgery.

公开(公告)号：US10278752B2

公开(公告)日：2019-05-07

申请号：US15293283

申请日：2016-10-14

Applicant: KAOHSIUNG MEDICAL UNIVERSITY ,  NATIONAL SUN YAT-SEN UNIVERSITY

Inventor： Jau-Sheng Wang ,  Tien-Ching Lee ,  Mei-Ling Ho ,  Yin-Chih Fu ,  Wei-Chi Chen

IPC: A61B17/72 ,  A61B17/84 ,  A61B17/17 ,  A61B90/30 ,  A61B17/90

Abstract: A bone nail apparatus includes a bone nail, a light source unit and a focalizing unit. The bone nail has a tube wall and at least one through hole. The tube wall is enclosed to form a receiving space. The at least one through hole extends through the tube wall and communicates with the receiving space. The light source unit includes a light emitter and at least one light transmission tube. The at least one light transmission tube is connected to the light emitter and receives a light therefrom. The at least one light transmission tube is received in the receiving space of the bone nail. Each light transmission tube has a light-outputting end aligned with a respective one of the at least one through hole. The focalizing unit has a light-receiving face facing one of the at least one through hole.