公开(公告)号：US20190203265A1

公开(公告)日：2019-07-04

申请号：US16355852

申请日：2019-03-18

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Ming-Tsang Wu ,  Deng-Chyang Wu ,  Hung-Ju Su ,  Shah-Hwa Chou ,  Jie-Len Huang ,  Yu-Kuei Chen ,  Chun-Chieh Wu

IPC: C12Q1/686 ,  C12Q1/6876

CPC classification number: C12Q1/686 ,  C12Q1/6876 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/16

Abstract: The present invention provides a method for determining a survival rate and prognosis state and providing care for a patient having esophageal carcinoma, comprising: (a) providing a tissue sample from the patient; (b) measuring an expression level of a plurality of target genes comprising peptidase inhibitor 3 (PI3) and CD14 in the tissue sample from the patient using reagents specific for a gene product of the plurality of target genes that are selected from the group consisting of probes, primers, antibodies, and antibody fragments, wherein the expression level is measured by RNA expression or protein expression; (c) comparing the expression level of the plurality of target genes to a predetermined threshold indicative of a survival rate and prognosis state for the patient; and (d) providing care for the patient when the survival rate and prognosis state is worse, wherein the care is advising the patent to reduce the time between return visit or to add adjuvant chemotherapy after surgery.

公开(公告)号：US20160319372A1

公开(公告)日：2016-11-03

申请号：US15216719

申请日：2016-07-22

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Ming-Tsang ; Wu ,  Deng-Chyang Wu ,  Hung-Ju Su ,  Chah-Hwa Chou ,  Jie-Len Huang ,  Yu-Kuei Chen ,  Chun-Chieh Wu

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2333/70596 ,  G01N2333/811 ,  G01N2800/52

Abstract: The present invention provides a method for determining a survival rate and prognosis state for a patient having esophageal carcinoma, comprising: (a) providing a tissue sample from the patient; (b) measuring a expression level of a target gene in the tissue sample from the patient using reagents specific for the target gene product that are selected from the group consisting of probes, primers, antibodies, and antibody fragments, wherein the expression level is RNA expression, a protein expression at a cellular level or a tissue level; (c) comparing the expression level to a predetermined threshold indicative of a survival rate and prognosis state for the patient; and (d) providing a survival rate and prognosis state for the patient so that care for the patient is able to be determined in accordance with the survival rate and prognosis state, wherein the target gene is peptidase inhibitor 3 (PI3).

Abstract translation: 本发明提供了一种用于确定患有食管癌的患者的存活率和预后状态的方法，包括：（a）从患者提供组织样品; （b）使用选自探针，引物，抗体和抗体片段的靶基因产物特异的试剂测量来自患者的组织样品中靶基因的表达水平，其中所述表达水平为RNA 表达，细胞水平或组织水平的蛋白质表达; （c）将表达水平与指示患者的存活率和预后状态的预定阈值进行比较; 和（d）为患者提供存活率和预后状态，以便能够根据存活率和预后状态确定患者的护理，其中靶基因是肽酶抑制剂3（PI3）。