公开(公告)号：US20160103139A1

公开(公告)日：2016-04-14

申请号：US14787146

申请日：2014-04-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Young Soo KIM ,  Dong Jin KIM ,  Hye Yun KIM ,  Soo Min CHO ,  Tae Song KIM ,  Hyunjin KIM ,  Sejin LEE ,  Kyoseon HWANG ,  Jee Hoon ROH ,  Jae-Young KOH

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  A61K38/1716 ,  C07K14/4711 ,  G01N33/6827 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

Abstract: The present disclosure relates to a diagnostic kit capable of accurately diagnosing diseases or disorders related with abnormal aggregation or misfolding of proteins, including disorders or diseases caused by aggregation of β-amyloid such as Alzheimer's disease as well as disorders or diseases caused by aggregation of other proteins, based on concentration analysis of the aggregated proteins before and after dissociation.

Abstract translation: 本公开涉及能够精确诊断与蛋白质的异常聚集或错误折叠相关的疾病或病症的诊断试剂盒，包括由淀粉样蛋白（例如阿尔茨海默氏症）聚集引起的疾病或疾病以及由聚集引起的疾病或疾病 其他蛋白质，基于聚合蛋白质在解离前后的浓度分析。

公开(公告)号：US20190025241A1

公开(公告)日：2019-01-24

申请号：US16070672

申请日：2016-10-20

Applicant: Korea Institute of Science and Technology

Inventor： Kyo Seon HWANG ,  Young Soo KIM ,  Jin Sik KIM ,  Yong Kyoung YOO

IPC: G01N27/327 ,  G01N27/12 ,  G01N33/543 ,  G01N33/68

Abstract: The present invention relates to an interdigitated microelectrode biosensor using the reaction between receptors and target biomaterials, the interdigitated microelectrode biosensor comprising: an insulating layer formed so as to cover all of the sensor formation area of a substrate; a first interdigitated microelectrode formed such that a plurality of first protruding electrodes are arranged in a comb shape on the insulating layer of the substrate; a second interdigitated microelectrode, facing the first interdigitated microelectrode and formed such that a plurality of second protruding electrodes are arranged in a comb shape on the insulating layer of the substrate such that the plurality of second protruding electrodes are arranged to respectively interdigitate with the plurality of first protruding electrodes formed at the first interdigitated microelectrode; and a plurality of receptors arranged in the space between the first and second interdigitated microelectrodes, which are arranged to interdigitate with each other, so as to specifically react with the target biomaterial, thereby increasing an impedance detection width and detection limit, and improving detection accuracy according to the characteristics of each monomer and each polymer.

公开(公告)号：US20180201835A1

公开(公告)日：2018-07-19

申请号：US15865259

申请日：2018-01-09

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Munju GOH ,  Hyeonuk YEO ,  Nam Ho YOU ,  Se Gyu JANG ,  Seokhoon AHN ,  Young Soo KIM

IPC: C09K19/38 ,  C09K19/12 ,  C09K19/30 ,  C09K19/32 ,  C09K19/22 ,  C09K19/16

CPC classification number: C09K19/388 ,  C09K19/12 ,  C09K19/16 ,  C09K19/22 ,  C09K19/24 ,  C09K19/3003 ,  C09K19/322 ,  C09K19/3411 ,  C09K2019/0448 ,  C09K2019/122 ,  C09K2019/2035 ,  C09K2019/3009 ,  C09K2019/323 ,  C09K2019/328

Abstract: Disclosed is a liquid crystalline epoxy compound wherein an epoxy group is positioned at a side chain of the longer direction of a mesogen group and each of the mesogen group and the epoxy group is connected to the center of the molecular structure through a flexible linkage. Since the liquid crystalline epoxy compound includes an epoxy group positioned at a side chain of the longer direction of a mesogen group and each of the mesogen group and the epoxy group is connected to the center of the molecular structure through a flexible linkage, the interaction between the mesogens in a cured resin product occurs significantly without weakening even after curing, thereby improving the heat conductivity of the resin compound through the active heat transfer between the mesogens.

公开(公告)号：US20180080946A1

公开(公告)日：2018-03-22

申请号：US15565503

申请日：2016-05-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ji Yoon KANG ,  Kyeong Sik SHIN ,  Jae Hoon JI ,  Tae Song KIM ,  Young Soo KIM ,  Sang Yun KIM

IPC: G01N33/68 ,  G01N27/02

CPC classification number: G01N33/6896 ,  G01N27/02 ,  G01N27/026 ,  G01N2333/47 ,  G01N2333/4709 ,  G01N2800/28

Abstract: The present invention relates to a method for diagnosing a disease using an analysis of oligomer of an abnormal aggregated protein includes: (1) preparing a body fluid sample including at least one of blood, blood plasma, blood serum, saliva, urine, tear, and mucus; (2) making a dilution of the body fluid sample; (3) using a biosensor to measure and detect an aggregated protein in the diluted body fluid sample; (4) analyzing a signal change of the biosensor caused by the dilution of the aggregated protein to determine a slope according to the dilution from the measurements; and (5) analyzing a proportion of the oligomer from the slope according to the dilution to make a diagnosis. The method uses a biosensor to measure the impedance and the protein concentration of blood and detects the slope according to the numerical value of the monomer and the oligomer to diagnose normal or abnormal protein aggregation or the associated diseases with more accuracy.