公开(公告)号：US20160103139A1

公开(公告)日：2016-04-14

申请号：US14787146

申请日：2014-04-25

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Young Soo KIM ,  Dong Jin KIM ,  Hye Yun KIM ,  Soo Min CHO ,  Tae Song KIM ,  Hyunjin KIM ,  Sejin LEE ,  Kyoseon HWANG ,  Jee Hoon ROH ,  Jae-Young KOH

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  A61K38/1716 ,  C07K14/4711 ,  G01N33/6827 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

摘要： The present disclosure relates to a diagnostic kit capable of accurately diagnosing diseases or disorders related with abnormal aggregation or misfolding of proteins, including disorders or diseases caused by aggregation of β-amyloid such as Alzheimer's disease as well as disorders or diseases caused by aggregation of other proteins, based on concentration analysis of the aggregated proteins before and after dissociation.

摘要翻译： 本公开涉及能够精确诊断与蛋白质的异常聚集或错误折叠相关的疾病或病症的诊断试剂盒，包括由淀粉样蛋白（例如阿尔茨海默氏症）聚集引起的疾病或疾病以及由聚集引起的疾病或疾病 其他蛋白质，基于聚合蛋白质在解离前后的浓度分析。

公开(公告)号：US20170298011A1

公开(公告)日：2017-10-19

申请号：US15516395

申请日：2015-09-24

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Ki Duk PARK ,  ChangJoon Justin LEE ,  Dong Jin KIM ,  Ae Nim PAE ,  Hyun Ah CHOO ,  Sun Joon MIN ,  Yong Koo KANG ,  Yun Kyung KIM ,  Hyo Jung SONG ,  Ji Won CHOI ,  Min Ho NAM ,  Jun Young HEO ,  Seul Ki YEON ,  Bo Ko JANG ,  Eun Ji JU ,  Seon Mi JO ,  Jong-Hyun PARK

IPC分类号： C07C237/06 ,  C07C231/12

摘要： The present disclosure relates to an α-aminoamide derivative compound and a pharmaceutical composition containing the same. According to various embodiments of the present disclosure, provided is a therapeutic agent which can overcome the disadvantages of existing drugs used as a MAO-B inhibitor and, specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of the existing drugs which exhibit a therapeutic effect by irreversibly acting via a covalent bond with MAO-B. Particularly, a new compound having superior stability and efficacy compared to the existing reversible MAO-B inhibitors may be provided.

公开(公告)号：US20150005306A1

公开(公告)日：2015-01-01

申请号：US14316963

申请日：2014-06-27

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Dong Jin KIM ,  Young Soo Kim ,  Hye Yun Kim ,  Hyun Jin Kim

IPC分类号： C07D295/15 ,  C07D295/088 ,  A61K31/5375 ,  A61K31/445 ,  A61K31/495

CPC分类号： C07D295/15 ,  A61K31/495 ,  A61K31/5375 ,  C07D295/088

摘要： Provided is a pharmaceutical composition for preventing or treating a cognitive impairment-related disease, the pharmaceutical composition including N-(2-hydroxyethyl)piperazine-N′(3-propane sulfonic acid), a pharmaceutically acceptable salt thereof or a derivative thereof, and donepezil, a pharmaceutically acceptable salt thereof or a derivative thereof. The composition may be used in preventing or treating a cognitive impairment-related disease.

摘要翻译： 提供了用于预防或治疗认知障碍相关疾病的药物组合物，所述药物组合物包括N-（2-羟乙基）哌嗪-N'（3-丙磺酸），其药学上可接受的盐或其衍生物，以及 多奈哌齐，其药学上可接受的盐或其衍生物。 该组合物可用于预防或治疗认知障碍相关疾病。