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1.发明授权Pharmaceutical composition for preventing or treating cognitive impairment-related disease comprising morpholine or piperazine based compounds, and donepezil 有权包含吗啉或哌嗪类化合物以及多奈哌齐的用于预防或治疗认知障碍相关疾病的药物组合物公开(公告)号：US09527824B2
公开(公告)日：2016-12-27
申请号：US14316963
申请日：2014-06-27
发明人： Dong Jin Kim , Young Soo Kim , Hye Yun Kim , Hyun Jin Kim
IPC分类号： A61K31/535 , C07D295/15 , A61K31/495 , A61K31/5375 , C07D295/088
CPC分类号： C07D295/15 , A61K31/495 , A61K31/5375 , C07D295/088
摘要： Provided is a pharmaceutical composition for preventing or treating a cognitive impairment-related disease, the pharmaceutical composition including N-(2-hydroxyethyl)piperazine-N′(3-propane sulfonic acid), a pharmaceutically acceptable salt thereof or a derivative thereof, and donepezil, a pharmaceutically acceptable salt thereof or a derivative thereof. The composition may be used in preventing or treating a cognitive impairment-related disease.
摘要翻译： 提供了用于预防或治疗认知障碍相关疾病的药物组合物，所述药物组合物包括N-（2-羟乙基）哌嗪-N'（3-丙磺酸），其药学上可接受的盐或其衍生物，以及 多奈哌齐，其药学上可接受的盐或其衍生物。 该组合物可用于预防或治疗认知障碍相关疾病。
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2.发明申请AMINOSTYRYLBENZOFURAN DERIVATIVES AS INHIBITORS AGAINST BETA-AMYLOID FIBRIL FORMATION, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开作为抗β-淀粉样蛋白形成的抑制剂的氨基苯丙酮衍生物和包含其的药物组合物公开(公告)号：US20150065494A1
公开(公告)日：2015-03-05
申请号：US14389609
申请日：2013-04-01
发明人： Dong Jin Kim , Kyung Ho Yoo , Young Soo Kim , Woong Seo Park , Yong Koo Kang , Hye Yun Kim , Yun Kyung Kim , Ki Duk Park , Maeng Sup Kim , Kwee Hyun Suh , Young Gil Ahn
IPC分类号： C07D413/12 , C07D405/12 , C07D307/81
CPC分类号： C07D413/12 , C07D307/81 , C07D405/12
摘要： The present invention provides an aminostyrylbenzofuran compound of Formula (I), and a pharmaceutical composition comprising same. The pharmaceutical composition of the present invention comprising the compound of Formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof as an active ingredient can be useful for the prevention and treatment of degenerative brain diseases caused by accumulation of beta-amyloid.
摘要翻译： 本发明提供式（I）的氨基苯乙烯基苯并呋喃化合物和包含其的药物组合物。 包含式（I）化合物，其药学上可接受的盐，异构体，水合物和溶剂合物作为活性成分的本发明的药物组合物可用于预防和治疗由积累引起的退行性脑病 的β-淀粉样蛋白。
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3.发明申请PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING COGNITIVE IMPAIRMENT-RELATED DISEASE COMPRISING MORPHOLINE OR PIPERAZINE BASED COMPOUNDS, AND DONEPEZIL 有权用于预防或治疗包含吗啡或基于哌啶的化合物的认知性相关疾病的药物组合物和多西他赛公开(公告)号：US20150005306A1
公开(公告)日：2015-01-01
申请号：US14316963
申请日：2014-06-27
发明人： Dong Jin KIM , Young Soo Kim , Hye Yun Kim , Hyun Jin Kim
IPC分类号： C07D295/15 , C07D295/088 , A61K31/5375 , A61K31/445 , A61K31/495
CPC分类号： C07D295/15 , A61K31/495 , A61K31/5375 , C07D295/088
摘要： Provided is a pharmaceutical composition for preventing or treating a cognitive impairment-related disease, the pharmaceutical composition including N-(2-hydroxyethyl)piperazine-N′(3-propane sulfonic acid), a pharmaceutically acceptable salt thereof or a derivative thereof, and donepezil, a pharmaceutically acceptable salt thereof or a derivative thereof. The composition may be used in preventing or treating a cognitive impairment-related disease.
摘要翻译： 提供了用于预防或治疗认知障碍相关疾病的药物组合物，所述药物组合物包括N-（2-羟乙基）哌嗪-N'（3-丙磺酸），其药学上可接受的盐或其衍生物，以及 多奈哌齐，其药学上可接受的盐或其衍生物。 该组合物可用于预防或治疗认知障碍相关疾病。
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公开(公告)号：US10006920B2
公开(公告)日：2018-06-26
申请号：US14787146
申请日：2014-04-25
发明人： Young Soo Kim , Dong Jin Kim , Hye Yun Kim , Soo Min Cho , Tae Song Kim , Hyunjin Kim , Sejin Lee , Kyoseon Hwang , Jee Hoon Roh , Jae-Young Koh
CPC分类号： G01N33/6893 , A61K38/1716 , C07K14/4711 , G01N33/6827 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present disclosure relates to a diagnostic kit capable of accurately diagnosing diseases or disorders related with abnormal aggregation or misfolding of proteins, including disorders or diseases caused by aggregation of β-amyloid such as Alzheimer's disease as well as disorders or diseases caused by aggregation of other proteins, based on concentration analysis of the aggregated proteins before and after dissociation.
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