公开(公告)号：US10570155B2

公开(公告)日：2020-02-25

申请号：US16315263

申请日：2017-07-03

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Gamal El-din Mahmoud ,  Hong Seok Choi ,  Kyung Ho Yoo ,  Dong Keun Han ,  Chang Hyun Oh ,  Abdel-Maksoud Mohammed ,  I. El-Gamal Mohammed

IPC分类号： C07D513/04 ,  C07D498/04 ,  A61P35/00

摘要： Provided is a pharmaceutical composition for preventing and treating tumors, the pharmaceutical composition including an imidazooxazole derivative compound, a solvate, a stereoisomer, or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is administered to an entity which has developed a tumor or is in danger of developing a tumor, and thus tumors can be prevented or treated.

公开(公告)号：US11332479B2

公开(公告)日：2022-05-17

申请号：US16731277

申请日：2019-12-31

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Gamal El-din Mahmoud ,  Hong Seok Choi ,  Kyung Ho Yoo ,  Dong Keun Han ,  Chang Hyun Oh ,  Abdel-Maksoud Mohammed ,  I. El-Gamal Mohammed ,  Usama M. Ammar

IPC分类号： C07D498/04 ,  C07D513/04 ,  A61P35/00

摘要： Provided is a pharmaceutical composition for preventing and treating tumors, the pharmaceutical composition including an imidazooxazole derivative compound, a solvate, a stereoisomer, or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is administered to an entity which has developed a tumor or is in danger of developing a tumor, and thus tumors can be prevented or treated.

公开(公告)号：US10683282B2

公开(公告)日：2020-06-16

申请号：US16362571

申请日：2019-03-22

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： So Ha Lee ,  Kyung Ho Yoo ,  Eun Joo Roh ,  Tae Bo Sim ,  Tae Young Kim ,  Jae Ho Kim

IPC分类号： C07D405/14 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/48 ,  A61P35/00 ,  A61P25/28 ,  A61P37/02 ,  A61P29/00

摘要： Disclosed are a novel pyrimidine derivative compound, a pharmaceutically acceptable salt thereof, a method for preparing the compound and a pharmaceutical use of the compound as an anticancer agent or a therapeutic agent for degenerative brain diseases. Specifically, the novel pyrimidine derivative compound has excellent inhibitory activities against kinase enzymes such as ARK5/NUAK1, ACK1, FLT3, JAK1, JAK2 and JAK2 (V617F) and thus is useful for treating and preventing leukemia, ovarian cancer, breast cancer, non-small cell carcinoma, colorectal cancer, glioma, and brain protein abnormalities such as Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia, that is, degenerative diseases caused by Tau deposition.

公开(公告)号：US20150065494A1

公开(公告)日：2015-03-05

申请号：US14389609

申请日：2013-04-01

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Dong Jin Kim ,  Kyung Ho Yoo ,  Young Soo Kim ,  Woong Seo Park ,  Yong Koo Kang ,  Hye Yun Kim ,  Yun Kyung Kim ,  Ki Duk Park ,  Maeng Sup Kim ,  Kwee Hyun Suh ,  Young Gil Ahn

IPC分类号： C07D413/12 ,  C07D405/12 ,  C07D307/81

CPC分类号： C07D413/12 ,  C07D307/81 ,  C07D405/12

摘要： The present invention provides an aminostyrylbenzofuran compound of Formula (I), and a pharmaceutical composition comprising same. The pharmaceutical composition of the present invention comprising the compound of Formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof as an active ingredient can be useful for the prevention and treatment of degenerative brain diseases caused by accumulation of beta-amyloid.

摘要翻译： 本发明提供式（I）的氨基苯乙烯基苯并呋喃化合物和包含其的药物组合物。 包含式（I）化合物，其药学上可接受的盐，异构体，水合物和溶剂合物作为活性成分的本发明的药物组合物可用于预防和治疗由积累引起的退行性脑病 的β-淀粉样蛋白。