公开(公告)号：US10393747B2

公开(公告)日：2019-08-27

申请号：US15113006

申请日：2014-10-22

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jung Hoe Kim ,  Sung Hyeon Lee ,  Seung Yeol Park ,  Jin Man Kim ,  Hyun Joo An ,  Jae-Han Kim ,  Myung Jin Oh

IPC: G01N33/574

Abstract: This invention relates to a method for gastric cancer diagnosis through the detection of glycan changes, and to a kit for gastric cancer diagnosis. More specifically, based on the fact that in gastric cancer patient-derived haptoglobin, there are changes in N-linked glycosylation of haptoglobin, which are detected through lectin and mass spectrometery, that is, an increase in fucosylation, increases or significant changes in specific glycan structures depending on the classification of antennary structures, or a remarkable decrease in a high mannose structure of the N-glycan as compared to normal persons, N-glycan structures identified using the changes in N-linked glycosylation of haptoglobin may be usefully used as a diagnosis marker in a method for gastric cancer diagnosis using lectin or mass spectrometry, and a kit for gastric cancer diagnosis.

公开(公告)号：US20180164320A1

公开(公告)日：2018-06-14

申请号：US15580662

申请日：2015-12-16

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jung Hoe Kim ,  Sung Hyeon Lee ,  Seung Yeol Park ,  Hyun Joo An ,  Jae-Han Kim ,  Myung Jin Oh ,  Jin Man Kim ,  Ju A Lee

IPC: G01N33/574 ,  G01N30/86 ,  G01N30/72 ,  C07H5/04

CPC classification number: G01N33/57419 ,  C07H5/04 ,  G01N30/7233 ,  G01N30/8631 ,  G01N2030/027 ,  G01N2560/00

Abstract: The present invention relates to a method of diagnosing colorectal cancer by detection of glycan changes, and more particularly to a method of diagnosing colorectal cancer using mass spectrometry, in which, when specific glycan structures increase, decrease or significantly change due to a change in N-linked glycosylation of a colorectal cancer patient-derived glycoprotein, as detected by mass spectrometry, the glycan structures are selected as diagnostic markers.

公开(公告)号：US20180277872A1

公开(公告)日：2018-09-27

申请号：US15924890

申请日：2018-03-19

Applicant: Hyundai Motor Company ,  Korea Advanced Institute of Science and Technology

Inventor： Bo Ki Hong ,  Byeong-Heon Jeong ,  Taek-Soo Kim ,  Jae-Han Kim ,  Sanwi Kim

IPC: H01M8/1004 ,  H01M4/92 ,  H01M4/88

CPC classification number: H01M8/1004 ,  H01M4/8814 ,  H01M4/8875 ,  H01M4/926 ,  H01M2250/20 ,  Y02E60/521 ,  Y02T90/32

Abstract: Disclosed are a process for separating an electrode for membrane-electrode assemblies of fuel cells from the decal transfer film and an apparatus for separating the electrode. In particular, during the electrode separating process, only an electrode is separated from the decal transfer film on which the electrode is coated, without any damage, by a freezing method for freezing the specimen on the deionized water surface, and thus, wasting the expensive MEA is prevented. Thus, mechanical properties of the pristine electrode can be rapidly quantified in advance, and therefore, long term durability evaluation period during developing MEA having excellent durability is substantially reduced.

公开(公告)号：US09960442B2

公开(公告)日：2018-05-01

申请号：US14819079

申请日：2015-08-05

Applicant: Hyundai Motor Company ,  Korea Advanced Institute of Science and Technology

Inventor： Bo Ki Hong ,  Byeong-Heon Jeong ,  Taek-Soo Kim ,  Jae-Han Kim ,  Sanwi Kim

IPC: H01M4/88 ,  H01M8/1004 ,  H01M4/92

CPC classification number: H01M8/1004 ,  H01M4/8814 ,  H01M4/8875 ,  H01M4/926 ,  H01M2250/20 ,  Y02E60/521 ,  Y02T90/32

Abstract: Disclosed are a process for separating an electrode for membrane-electrode assemblies of fuel cells from the decal transfer film and an apparatus for separating the electrode. In particular, during the electrode separating process, only an electrode is separated from the decal transfer film on which the electrode is coated, without any damage, by a freezing method for freezing the specimen on the deionized water surface, and thus, wasting the expensive MEA is prevented. Thus, mechanical properties of the pristine electrode can be rapidly quantified in advance, and therefore, long term durability evaluation period during developing MEA having excellent durability is substantially reduced.

公开(公告)号：US20160126577A1

公开(公告)日：2016-05-05

申请号：US14819079

申请日：2015-08-05

Applicant: Hyundai Motor Company ,  Korea Advanced Institute of Science and Technology

Inventor： Bo Ki Hong ,  Byeong-Heon Jeong ,  Taek-Soo Kim ,  Jae-Han Kim ,  Sanwi Kim

IPC: H01M8/10 ,  H01M4/96 ,  H01M4/90 ,  H01M4/88

CPC classification number: H01M8/1004 ,  H01M4/8814 ,  H01M4/8875 ,  H01M4/926 ,  H01M2250/20 ,  Y02E60/521 ,  Y02T90/32

Abstract: Disclosed are a process for separating an electrode for membrane-electrode assemblies of fuel cells from the decal transfer film and an apparatus for separating the electrode. In particular, during the electrode separating process, only an electrode is separated from the decal transfer film on which the electrode is coated, without any damage, by a freezing method for freezing the specimen on the deionized water surface, and thus, wasting the expensive MEA is prevented. Thus, mechanical properties of the pristine electrode can be rapidly quantified in advance, and therefore, long term durability evaluation period during developing MEA having excellent durability is substantially reduced.

Abstract translation: 公开了一种从贴花转移膜分离燃料电池的膜 - 电极组件的电极和用于分离电极的装置的方法。 特别地，在电极分离过程中，通过用于将样品冷凝在去离子水表面上的冷冻方法，仅将电极与其上涂覆电极的贴花转印膜分离而没有任何损害，因此浪费昂贵的 MEA被阻止。 因此，可以预先快速量化原始电极的机械性能，因此在显影MEA中具有优异的耐久性的长期耐久性评价期间显着降低。

公开(公告)号：US10749197B2

公开(公告)日：2020-08-18

申请号：US15924890

申请日：2018-03-19

Applicant: Hyundai Motor Company ,  Korea Advanced Institute of Science and Technology

Inventor： Bo Ki Hong ,  Byeong-Heon Jeong ,  Taek-Soo Kim ,  Jae-Han Kim ,  Sanwi Kim

IPC: H01M8/1004 ,  H01M4/88 ,  H01M4/92

Abstract: Disclosed are a process for separating an electrode for membrane-electrode assemblies of fuel cells from the decal transfer film and an apparatus for separating the electrode. In particular, during the electrode separating process, only an electrode is separated from the decal transfer film on which the electrode is coated, without any damage, by a freezing method for freezing the specimen on the deionized water surface, and thus, wasting the expensive MEA is prevented. Thus, mechanical properties of the pristine electrode can be rapidly quantified in advance, and therefore, long term durability evaluation period during developing MEA having excellent durability is substantially reduced.