公开(公告)号：US20190046643A1

公开(公告)日：2019-02-14

申请号：US16161182

申请日：2018-10-16

Applicant: KLOX TECHNOLOGIES INC.

Inventor： Nikolaos LOUPIS ,  Remigio PIERGALLINI ,  Eric DESROSIERS

IPC: A61K41/00 ,  A61Q19/08 ,  A61K8/02 ,  A61Q19/00 ,  A61K8/04 ,  A61K8/49 ,  A61N5/06 ,  A61M35/00 ,  A61M11/00 ,  A61K47/36 ,  A61K8/73

Abstract: The present disclosure provides topical biophotonic materials and methods useful in phototherapy. In particular, the topical biophotonic materials of the present disclosure include a cohesive matrix, and at least one chromophore which can absorb and emit light from within the topical biophotonic material, wherein the topical biophotonic material is elastic. The topical bio-photonic materials and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various other skin disorders.

公开(公告)号：US20180256914A1

公开(公告)日：2018-09-13

申请号：US15745827

申请日：2016-07-21

Applicant: KLOX TECHNOLOGIES INC.

Inventor： Lise HÉBERT ,  Michel CIMON ,  David OHAYON ,  Nikolaos LOUPIS ,  Remigio PIERGALLINI

IPC: A61N5/06 ,  A61K41/00

CPC classification number: A61N5/062 ,  A61K9/006 ,  A61K31/352 ,  A61K33/40 ,  A61K41/0057 ,  A61K45/06 ,  A61N2005/0606 ,  A61N2005/0609 ,  A61N2005/0656 ,  A61N2005/0663 ,  Y02A50/473 ,  A61K2300/00

Abstract: The present disclosure provides compositions and methods for treating mucositis associated with treatment-induced neutropenia in a patient. The methods comprise applying a biophotonic composition comprising a fluorescent dye and a carrier to mucosal lesions and subsequently exposing the composition to actinic light.

公开(公告)号：US20220265828A1

公开(公告)日：2022-08-25

申请号：US17738104

申请日：2022-05-06

Applicant: KLOX TECHNOLOGIES INC.

Inventor： Nikolaos LOUPIS ,  Remigio PIERGALLINI ,  Eric DESROSIERS

IPC: A61K41/00 ,  A61N5/06 ,  A61K8/49 ,  A61Q19/00 ,  A61Q19/08 ,  A61K8/04 ,  A61K8/02 ,  A61K8/73 ,  A61K47/36 ,  A61M11/00

Abstract: The present disclosure provides topical biophotonic materials and methods useful in phototherapy. In particular, the topical biophotonic materials of the present disclosure include a cohesive matrix, and at least one chromophore which can absorb and emit light from within the topical biophotonic material, wherein the topical biophotonic material is elastic. The topical biophotonic materials and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various other skin disorders.

公开(公告)号：US20200147214A1

公开(公告)日：2020-05-14

申请号：US16632459

申请日：2018-07-18

Applicant: KLOX TECHNOLOGIES INC.

Inventor： Andreas NIKOLIS ,  Nikolaos LOUPIS ,  Remigio PIERGALLINI

IPC: A61K41/00 ,  A61K47/36 ,  A61L27/20 ,  A61N5/06 ,  A61K31/352

Abstract: The present disclosure generally relates to photo-biomodulation composition comprising a tissue filler and to methods for achieving photo-biomodulation. Specifically, but not exclusively, the present disclosure relates to photo-biomodulation compositions which can be injected into a tissue for achieving photo-biomodulation.

公开(公告)号：US20190366113A1

公开(公告)日：2019-12-05

申请号：US16536957

申请日：2019-08-09

Applicant: KLOX TECHNOLOGIES INC.

Inventor： Remigio PIERGALLINI ,  Nikolaos LOUPIS ,  Francesco BELLINI

IPC: A61N5/06 ,  A01H5/10 ,  A61Q19/00 ,  A61K47/46 ,  A61K47/22 ,  A61K47/18 ,  A61K47/02 ,  A61K45/06 ,  A61K41/00 ,  A61K33/40 ,  A61K31/737 ,  A61K31/728 ,  A61K31/7008 ,  A61K31/4166 ,  A61K31/404 ,  A61K31/403 ,  A61K8/73 ,  A61K31/17 ,  A61K31/352 ,  A61K31/353

Abstract: There is provided a wound healing composition which comprises at least one oxidant, at least one photoactivator capable of activating the oxidant and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin in association with a pharmaceutically acceptable carrier. In addition, a method of topically treating wounds using at least one oxidant and at least one photoactivator capable of activating the oxidant followed by illumination of said photosensitizer is disclosed.

公开(公告)号：US20190269777A1

公开(公告)日：2019-09-05

申请号：US16413683

申请日：2019-05-16

Applicant: KLOX TECHNOLOGIES INC.

Inventor： Remigio PIERGALLINI ,  Nikolaos LOUPIS

IPC: A61K41/00 ,  A61K31/327 ,  A61N5/06 ,  A61K33/40 ,  A61K31/4166 ,  A61K9/00 ,  A61K8/60 ,  A61K8/73 ,  A61K8/97 ,  A61Q17/00 ,  A61Q11/00 ,  A61K8/38 ,  A61K8/49 ,  A61K45/06 ,  A61K31/728 ,  A61K31/7008

Abstract: The present document describes methods of use of photo activated compositions for oral disinfection and/or treatments which comprise at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmacologically acceptable carrier.

公开(公告)号：US20190143137A1

公开(公告)日：2019-05-16

申请号：US16210034

申请日：2018-12-05

Applicant: KLOX TECHNOLOGIES INC.

Inventor： Remigio PIERGALLINI ,  Nikolaos LOUPIS ,  Francesco BELLINI

IPC: A61N5/06 ,  A61K31/404 ,  A61Q19/00 ,  A61K31/17 ,  A61K47/22 ,  A61K47/02 ,  A61K47/18 ,  A01H5/10 ,  A61K8/73 ,  A61K47/46 ,  A61K45/06 ,  A61K41/00 ,  A61K33/40 ,  A61K31/728 ,  A61K31/7008 ,  A61K31/4166 ,  A61K31/403 ,  A61K31/353 ,  A61K31/352 ,  A61K31/737

Abstract: There is provided a method for treating rosacea comprising a composition which comprises at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmaceutically acceptable carrier.

公开(公告)号：US20220111050A1

公开(公告)日：2022-04-14

申请号：US17557205

申请日：2021-12-21

Applicant: KLOX TECHNOLOGIES INC.

Inventor： Remigio PIERGALLINI ,  Nikolaos LOUPIS ,  David OHAYON ,  Kevin WILKINSON ,  Giovanni SCAPAGNINI

IPC: A61K41/00 ,  A61K9/00 ,  A61K31/365 ,  A61N5/06 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10

Abstract: The present document describes methods of using compositions for inhibiting biofilm formation, or disrupting existing or developing biofilms in a subject, which composition comprises at least one chromophore and a pharmacologically acceptable carrier.

公开(公告)号：US20210177969A1

公开(公告)日：2021-06-17

申请号：US17130587

申请日：2020-12-22

Applicant: KLOX TECHNOLOGIES INC.

Inventor： Nikolaos LOUPIS ,  Remigio PIERGALLINI ,  Shipra RASTOGI

IPC: A61K41/00 ,  C09K11/06 ,  A61L26/00 ,  A61N5/06

Abstract: The present disclosure provides biophotonic compositions, kits and their uses. In particular, the biophotonic compositions of the present disclosure arc substantially resistant to leaching such that low amounts of chromophores present in the biophotonic composition leach out of the composition. The biophotonic compositions and their uses are useful for promoting repair of non-healing wounds.

公开(公告)号：US20200376121A1

公开(公告)日：2020-12-03

申请号：US16333794

申请日：2017-09-22

Applicant: KLOX TECHNOLOGIES INC.

Inventor： Andreas NIKOLIS ,  Marco ROMANELLI ,  Nikolaos LOUPIS ,  Remigio PIERGALLINI ,  Valentina DINI

IPC: A61K41/00 ,  A61P17/02 ,  A61K31/728 ,  A61K31/7008 ,  A61K31/4166

Abstract: The present document describes methods and uses of compositions which comprise at least one photoactivator or chromophore in association with a pharmacologically acceptable carrier for use in reducing pain that is associated with a medical condition in a subject.