公开(公告)号：US08742367B2

公开(公告)日：2014-06-03

申请号：US12739144

申请日：2008-10-08

申请人： Jyrki Laitinen ,  Petri Kivelä

发明人： Jyrki Laitinen ,  Petri Kivelä

IPC分类号： G01N21/64 ,  G01J3/10 ,  G01J3/44 ,  G01N21/25 ,  G01J3/42 ,  G01J3/12 ,  G02B6/42 ,  G01J3/02

CPC分类号： G01N21/253 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/12 ,  G01J3/42 ,  G01J3/44 ,  G01N21/6408 ,  G01N21/6452 ,  G01N2021/6439 ,  G01N2021/6484 ,  G01N2021/6491 ,  G02B6/4298

摘要： An apparatus for optically analyzing samples contained in sample sites of a sample holder, the apparatus has a first light source and at least one second light source, a monochromator having an input to which first light source is optically connected or connectable and an output for monochromatized light, light guiding portion for guiding light originating from the first and from the at least one second light sources to the sample sites, and a detector for detecting light from the sample sites. A light relay having a first input optically connected to the output of the monochromator, at least one second input optically connected or connectable to a second light source such that the light from the second light source by-passes the monochromator, and a first output for guiding light from selected input of the light relay to the sample sites. Based on the apparatus and light relay a versatile sample analyzer can be achieved in a cost-effective manner.

摘要翻译： 一种用于光学分析样品保持器的样品位置中包含的样品的装置，该装置具有第一光源和至少一个第二光源，具有第一光源被光学连接或可连接的输入的单色仪和用于单色化的输出 用于引导来自第一和至少一个第二光源的光源到样品位置的光，光引导部分，以及用于检测来自样品位点的光的检测器。 一种光继电器，具有光学连接到单色仪的输出的第一输入，至少一个第二输入，光学连接或可连接到第二光源，使得来自第二光源的光旁路单色器，以及第一输出， 将光继电器的选定输入的光引导到样品位置。 基于设备和光继电器，可以以成本有效的方式实现通用的样品分析仪。

公开(公告)号：US09006684B2

公开(公告)日：2015-04-14

申请号：US12738843

申请日：2008-10-08

申请人： Jyrki Laitinen ,  Petri Kivelä

发明人： Jyrki Laitinen ,  Petri Kivelä

IPC分类号： G01J1/58 ,  G01N21/64 ,  G01J3/02 ,  G01J3/10 ,  G01J3/18 ,  G01J3/44 ,  G01N21/25

CPC分类号： G01N21/6452 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/18 ,  G01J3/4406 ,  G01N21/253 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0806

摘要： The invention relates to an apparatus and method for optically analyzing samples contained in sample sites of a sample holder by means of fluorescence. The apparatus comprises a first light source comprising a plurality of individual light sources having narrow wavelength bands, means for further limiting wavelength bands of the light emitted by the individual light sources, means for guiding the reduced-wavelength light to the sample sites of the sample holder, and a detector for detecting light from the sample sites. According to the invention said means for further reducing the wavelength bands emitted by the individual light sources comprise a wavelength-tunable single monochromator. The invention allows manufacturing of a microplate reader having the capability for fluorescence measurements at a continuous wavelength range, while maintaining the cost of the device at a reasonable level.

摘要翻译： 本发明涉及一种用于通过荧光光学分析样品保持器的样品位点中包含的样品的装置和方法。 该装置包括：第一光源，其包括具有窄波长带的多个单独的光源;用于进一步限制由各个光源发射的光的波长带的装置;用于将所述还原波长的光引导到所述样品的样品位置的装置 支架和用于检测来自样品位点的光的检测器。 根据本发明，用于进一步减少由各个光源发射的波长带的装置包括波长可调单色器。 本发明允许制造具有在连续波长范围内的荧光测量能力的酶标仪，同时将装置的成本保持在合理的水平。

公开(公告)号：US20110049385A1

公开(公告)日：2011-03-03

申请号：US12738843

申请日：2008-10-08

申请人： Jyrki Laitinen ,  Petri Kivelä

发明人： Jyrki Laitinen ,  Petri Kivelä

IPC分类号： G01N21/64

CPC分类号： G01N21/6452 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/18 ,  G01J3/4406 ,  G01N21/253 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0806

摘要： The invention relates to an apparatus and method for optically analysing samples contained in sample sites of a sample holder by means of fluorescence. The apparatus comprises a first light source comprising a plurality of individual light sources having narrow wavelength bands, means for further limiting wavelength bands of the light emitted by the individual light sources, means for guiding the reduced-wavelength light to the sample sites of the sample holder, and a detector for detecting light from the sample sites. According to the invention said means for further reducing the wavelength bands emitted by the individual light sources comprise a wavelength-tunable single monochromator. The invention allows manufacturing of a microplate reader having the capability for fluorescence measurements at a continuous wavelength range, while maintaining the cost of the device at a reasonable level.

摘要翻译： 本发明涉及一种用于通过荧光光学分析样品保持器的样品位点中包含的样品的装置和方法。 该装置包括：第一光源，其包括具有窄波长带的多个单独的光源;用于进一步限制由各个光源发射的光的波长带的装置;用于将所述还原波长的光引导到所述样品的样品位置的装置 支架和用于检测来自样品位点的光的检测器。 根据本发明，用于进一步减少由各个光源发射的波长带的装置包括波长可调单色器。 本发明允许制造具有在连续波长范围内的荧光测量能力的酶标仪，同时将装置的成本保持在合理的水平。

公开(公告)号：US20100308234A1

公开(公告)日：2010-12-09

申请号：US12739146

申请日：2009-01-23

申请人： Raimo Harju ,  Petri Kivelä ,  Jyrki Laitinen ,  Pauli Salmelainen ,  Jarkko Sarmaala

发明人： Raimo Harju ,  Petri Kivelä ,  Jyrki Laitinen ,  Pauli Salmelainen ,  Jarkko Sarmaala

IPC分类号： G01N21/64 ,  G01J3/12

CPC分类号： G01N21/6452 ,  G01J3/4406 ,  G01N2021/6417 ,  G01N2021/6463 ,  G01N2021/6484

摘要： The invention concerns a measurement system and method for optical spectroscopic measurement of samples. The system comprises an illumination source for forming a primary light beam, a first tunable monochromator for spectrally filtering the primary light beam, a sample-receiving zone to which the spectrally filtered primary beam is directed for producing a secondary light beam affected by a sample in the sample receiving zone, and a second tunable monochromator for spectrally filtering the secondary light beam, and a detector for measuring the intensity of the spectrally filtered secondary beam. In particular, the system is adapted to scan a predefined wavelength range using one of the monochromators and to tune the other monochromator sequentially to one of at least two predefined separate wavelengths in order to eliminate the effect of undesired diffraction orders of the second monochromator on the measurement. The invention allows for eliminating the use of optical diffraction order filters on the emission side of a fluorescence measurement system.

摘要翻译： 本发明涉及用于样品光谱测量的测量系统和方法。 该系统包括用于形成初级光束的照明源，用于对初级光束进行光谱滤波的第一可调谐单色仪，频谱滤波的主光束被引导到的采样接收区，以产生受样品影响的次级光束 采样接收区和用于频谱滤波二次光束的第二可调谐单色仪，以及用于测量光谱滤波次级光束强度的检测器。 特别地，该系统适于使用单色仪之一扫描预定波长范围，并且将另一个单色仪依次调谐到至少两个预定义的单独波长中的一个，以消除第二单色仪的不需要的衍射级的影响 测量。 本发明允许消除在荧光测量系统的发射侧使用光学衍射级滤光器。

公开(公告)号：US20100252748A1

公开(公告)日：2010-10-07

申请号：US12739144

申请日：2008-10-08

申请人： Jyrki Laitinen ,  Petri Kivelä

发明人： Jyrki Laitinen ,  Petri Kivelä

IPC分类号： G01J1/58 ,  G01N21/64

CPC分类号： G01N21/253 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/12 ,  G01J3/42 ,  G01J3/44 ,  G01N21/6408 ,  G01N21/6452 ,  G01N2021/6439 ,  G01N2021/6484 ,  G01N2021/6491 ,  G02B6/4298

摘要： The invention relates to an apparatus for optically analysing samples contained in sample sites of a sample holder, the apparatus comprising a first light source and at least one second light source, a monochromator having an input to which first light source is optically connected or connectable and an output for monochromatized light, light guiding means for guiding light originating from the first and from the at least one second light sources to the sample sites, and a detector for detecting light from the sample sites. According to the invention, the apparatus further comprises a light relay comprising a first input optically connected to the output of the monochromator, at least one second input optically connected or connectable to a second light source such that the light from the second light source by-passes the monochromator, and a first output for guiding light from selected input of the light relay to the sample sites. By means of the invention, a versatile sample analyser can be achieved in a cost-effective manner.

摘要翻译： 本发明涉及一种用于光学分析样品架的样品位置中包含的样品的装置，该装置包括第一光源和至少一个第二光源，单色仪具有第一光源被光学连接或连接的输入端， 用于单色光的输出，用于将源自第一和至少一个第二光源的光引导到样品位置的光引导装置，以及用于检测来自样品位点的光的检测器。 根据本发明，该装置还包括光继电器，其包括光学连接到单色仪的输出的第一输入，至少一个第二输入，其光学连接或可连接到第二光源，使得来自第二光源旁路的光， 通过单色器，以及第一输出，用于将来自所述光继电器的所选输入的光引导到所述样本位置。 通过本发明，可以以成本有效的方式实现通用的样品分析仪。

公开(公告)号：US20070247628A1

公开(公告)日：2007-10-25

申请号：US11662468

申请日：2004-09-10

申请人： Petri Kivelä

发明人： Petri Kivelä

IPC分类号： G01N21/00

CPC分类号： G01N21/253 ,  G01N21/13 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0826 ,  G01N2201/103

摘要： The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on microtitration plates and corresponding sample supports. An optical measurement instrumentation is provided, a sample is activated and the emission is detected, wherein between the activation and detection phases of measuring the sample, a shift is made in the relative position between the sample and elements directing the activation radiation to the sample as well as in the relative position between the sample and the elements receiving the emission radiation from the sample. This can be implemented e.g. by moving the sample assay plate and/or a measuring head between the activation and emission phases of a sample. The invention allows a simultaneous activation of a first sample and detecting emission from a second sample thus enhancing efficiency of the measurement.

摘要翻译： 本发明一般涉及生物化学实验室仪器领域，用于不同应用样品在微量滴定板和相应样品载体上的测量性质。 提供光学测量仪器，激活样品并检测发射，其中在测量样品的激活和检测阶段之间，在将样品和将激活辐射指向样品的元件之间的相对位置进行偏移，作为 以及在样品和接收来自样品的发射辐射的元件之间的相对位置。 这可以被实现。 通过在样品的活化和发射阶段之间移动样品测定板和/或测量头。 本发明允许同时激活第一样品并检测来自第二样品的发射，从而提高测量的效率。