公开(公告)号：US20120283315A1

公开(公告)日：2012-11-08

申请号：US13393141

申请日：2010-08-30

Applicant: Marc S. Penn ,  Rahul Aras ,  Joseph Pastore ,  Timothy R. Miller

Inventor： Marc S. Penn ,  Rahul Aras ,  Joseph Pastore ,  Timothy R. Miller

IPC: A61K31/711 ,  A61P9/10

CPC classification number: A61K38/19 ,  A61K9/0019 ,  A61K31/711 ,  A61K38/00 ,  A61K48/005 ,  C07K14/521 ,  C07K2319/02 ,  C07K2319/09

Abstract: A method of treating a cardiomyopathy in a subject includes administering directly to or expressing locally in a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification.

Abstract translation: 治疗受试者心肌病的方法包括在受试者的心肌组织的弱化，缺血和/或梗死周围区域内直接施用或表达一定量的有效引起至少一种功能改善的SDF-1 的以下参数：左心室容积，左心室面积，左心室尺寸，心脏功能，6分钟步行测试或纽约心脏协会（NYHA）功能分类。

公开(公告)号：US20080091138A1

公开(公告)日：2008-04-17

申请号：US11998969

申请日：2007-12-03

Applicant: Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

Inventor： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

IPC: A61M31/00

CPC classification number: A61M5/1723 ,  A61B5/0031 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61M5/14244 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/3627

Abstract: A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

Abstract translation: 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。

公开(公告)号：US20070260284A1

公开(公告)日：2007-11-08

申请号：US11381211

申请日：2006-05-02

Applicant: Joseph Pastore ,  Tamara Baynham ,  Andrew Kramer ,  Julio Spinelli ,  Jeffrey Ross ,  Rodney Salo

Inventor： Joseph Pastore ,  Tamara Baynham ,  Andrew Kramer ,  Julio Spinelli ,  Jeffrey Ross ,  Rodney Salo

IPC: A61N1/362

CPC classification number: A61N1/36114 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/3956

Abstract: Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.

Abstract translation: 各种系统实施例包括神经刺激器，脉冲发生器和控制器。 神经刺激器适于产生神经刺激信号。 脉冲发生器适用于产生起搏信号以提供心肌起搏。 控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。 调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。 本文提供了其它方面和实施例。

公开(公告)号：US20060259088A1

公开(公告)日：2006-11-16

申请号：US11129058

申请日：2005-05-13

Applicant: Joseph Pastore ,  Andrew Kramer ,  Julio Spinelli ,  Rodney Salo ,  Tamara Baynham ,  Jeffrey Ross ,  Frits Prinzen ,  Ward Vanagt ,  Richard Cornelussen

Inventor： Joseph Pastore ,  Andrew Kramer ,  Julio Spinelli ,  Rodney Salo ,  Tamara Baynham ,  Jeffrey Ross ,  Frits Prinzen ,  Ward Vanagt ,  Richard Cornelussen

IPC: A61N1/362

CPC classification number: A61N1/056 ,  A61N1/3627 ,  A61N1/36557 ,  A61N1/37205 ,  A61N1/3787 ,  A61N2001/0585

Abstract: An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.

公开(公告)号：US20060217773A1

公开(公告)日：2006-09-28

申请号：US11088231

申请日：2005-03-23

Applicant: Qingsheng Zhu ,  Joseph Pastore ,  Rodney Salo

Inventor： Qingsheng Zhu ,  Joseph Pastore ,  Rodney Salo

IPC: A61N1/362

CPC classification number: A61N1/368 ,  A61N1/0587 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

Abstract: A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

公开(公告)号：US20060161209A1

公开(公告)日：2006-07-20

申请号：US11037309

申请日：2005-01-18

Applicant: Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

Inventor： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

IPC: A61N1/362

CPC classification number: A61N1/365 ,  A61N1/36592

Abstract: A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.

Abstract translation: 心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。 产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。 在一个实施例中，当HRV参数被认为对继续治疗有潜在危害时，将HRV参数用作安全检查以停止电疗法。

公开(公告)号：US20050283195A1

公开(公告)日：2005-12-22

申请号：US10871865

申请日：2004-06-18

Applicant: Joseph Pastore ,  Steven Girouard

Inventor： Joseph Pastore ,  Steven Girouard

IPC: A61B5/00 ,  A61B5/0265 ,  A61B5/11 ,  A61B8/12 ,  A61N1/362 ,  A61N1/37

CPC classification number: A61B5/4839 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0265 ,  A61B5/1107 ,  A61B5/6869 ,  A61B8/12 ,  A61B2562/0219 ,  A61N1/3702

Abstract: A catheter with a tissue property sensor provides for localization of myocardial infarction (MI) by utilizing one or more differences between properties of infarcted myocardial tissue and properties of normal myocardial tissue. The tissue property sensor is to be placed on endocardial wall or epicardial wall during catheterization to sense at least one tissue property allowing for detection of MI. Examples of the tissue property sensor include, but are not limited to, an optical sensor, an acoustic sensor, a contractility sensor, a temperature sensor, and a drug response sensor. In one embodiment, the tissue property sensor senses a tissue property in various locations on endocardial wall or epicardial wall and detects substantial changes in the tissue property that indicate a boundary between infarcted tissue and normal tissue.

Abstract translation: 具有组织属性传感器的导管通过利用梗死心肌组织的性质与正常心肌组织的性质之间的一个或多个差异来提供心肌梗死（MI）的定位。 在导管插入期间，将组织性质传感器放置在心内膜壁或心外膜上以感测至少一个允许检测MI的组织特性。 组织性质传感器的实例包括但不限于光学传感器，声学传感器，收缩性传感器，温度传感器和药物响应传感器。 在一个实施例中，组织性质传感器检测心内膜壁或心外壁上各种位置的组织特性，并且检测指示梗塞组织与正常组织之间的边界的组织性质的实质性变化。

公开(公告)号：US5922195A

公开(公告)日：1999-07-13

申请号：US944283

申请日：1997-10-06

Applicant: Joseph Pastore

Inventor： Joseph Pastore

IPC: B01D29/05 ,  B07B1/46 ,  E02B5/08 ,  B01D39/14 ,  B01D39/16 ,  B01D29/03

CPC classification number: E02B5/085 ,  B01D29/05 ,  B07B1/4609

Abstract: A trash rack for filtering large volumes of intake water generally of the type available to power-generating facilities. The trash rack includes reinforcing rods fabricated of non-metallic materials in a pultrusion fabrication process. The pultruded reinforcing rods are substantially lighter than prior steel reinforcing rods. The pultruded rods are flexible enough to give under impact and high-loading without fracture or permanent distortion, yet are strong enough to withstand the type of loading commonly experienced by such large-volume trash racks.

Abstract translation: 用于过滤大量进水的垃圾架，通常是可用于发电设施的类型。 垃圾架包括在拉挤制造工艺中由非金属材料制成的加强杆。 拉挤的加强棒比现有的钢筋更为轻便。 拉挤的棒材具有足够的柔韧性，能够承受冲击和高负荷而不会发生断裂或永久变形，但足够坚固以承受这种大容量垃圾架通常遇到的负载类型。

公开(公告)号：US5692451A

公开(公告)日：1997-12-02

申请号：US421549

申请日：1995-04-13

Applicant: Joseph Pastore

Inventor： Joseph Pastore

IPC: B63B13/02 ,  B63B39/03

CPC classification number: B63B13/02 ,  B63B2231/42

Abstract: A sea chest cover for providing access to the sea chest of a ship. The sea chest cover is fabricated essentially entirely of one or more viscoelastic materials, preferably either polyethylene or polyurethane. Fabrication of the sea chest cover from a viscoelastic material reduces or eliminates corrosion and erosion problems. It also minimizes marine organism and ice build-up. The result is a reduction in the expense associated with maintaining such covers. The fabrication of the sea chest cover essentially entirely of viscoelastic materials minimizes the weight of such components, thereby making handling and maintenance easier. The sea chest cover is either pre-formed to a shape conforming with the shape of the ship's hull in the area where the sea chest is located, or it is sufficiently flexible to be placed into such conformance. The sea chest cover of the present invention may be formed as a unitary piece or as a plurality of removably connectable parts.

Abstract translation: 用于提供进入船舶海底的海底胸罩。 海胸罩基本上完全由一种或多种粘弹性材料制成，优选聚乙烯或聚氨酯。 从粘弹性材料制作海胸罩减少或消除腐蚀和侵蚀问题。 它还最大限度地减少海洋生物和冰块的积聚。 结果是减少与维护这种盖子相关的费用。 海底罩基本上完全由粘弹性材料的制造使这些部件的重量最小化，从而使得处理和维护更容易。 海胸罩或者预先形成为符合船体在海底所在区域的形状，或者它具有足够的弹性以便被放置在这样的一致性中。 本发明的海胸罩可以形成为整体件或多个可拆卸地连接的部件。

公开(公告)号：US08883756B2

公开(公告)日：2014-11-11

申请号：US13912435

申请日：2013-06-07

Applicant: Marc S. Penn ,  Rahul Aras ,  Joseph Pastore ,  Timothy J. Miller

Inventor： Marc S. Penn ,  Rahul Aras ,  Joseph Pastore ,  Timothy J. Miller

IPC: A61K38/00 ,  C07K14/52 ,  A61K48/00 ,  A61K9/00 ,  A61K38/19 ,  A61K31/711

CPC classification number: A61K38/19 ,  A61K9/0019 ,  A61K31/711 ,  A61K38/00 ,  A61K48/005 ,  C07K14/521 ,  C07K2319/02 ,  C07K2319/09

Abstract: Provided herein are methods of treating a cardiomyopathy in a subject by administering directly to, or expressing locally in, a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification. Also provided are methods of treating critical limb ischemia in a subject by administering a DNA plasmid encoding human SDF-1 by direct injection into the affected limb.

Abstract translation: 本文提供了通过直接施用或表达受试者心肌组织的弱化，缺血和/或梗死周围区域来治疗受试者的心肌病的方法，所述量的SDF-1有效引起功能改善 在以下参数中的至少一个中：左心室容积，左心室面积，左心室尺寸，心脏功能，6分钟步行测试或纽约心脏协会（NYHA）功能分类。 还提供了通过直接注射到受影响的肢体中来施用编码人SDF-1的DNA质粒来治疗受试者的关键性肢体缺血的方法。