公开(公告)号：US4087327A

公开(公告)日：1978-05-02

申请号：US676100

申请日：1976-04-12

Applicant: Joseph Feder ,  Katharine Ku ,  Mau-Jung Kuo

Inventor： Joseph Feder ,  Katharine Ku ,  Mau-Jung Kuo

IPC: C12M3/04 ,  C12M3/06 ,  C12N5/02 ,  C12N5/06 ,  C12K9/00 ,  C12B1/10

CPC classification number: C12M23/04 ,  C12M29/16

Abstract: A cell culture reactor system is provided for the growth of cells in vitro which employs elongate hollow or solid fibers arranged in a shallow layer configuration as a matrix for cell attachment in which the flow path of the culture media is directed substantially uniformly through the fiber layer and substantially transverse to the plane of the elongate axes of the fibers.

Abstract translation: 提供细胞培养反应器系统用于体外细胞的生长，其采用以浅层构型布置的细长的中空或固体纤维作为细胞附着的基质，其中培养基的流动路径基本均匀地通过纤维层 并且基本上横向于纤维的细长轴的平面。

公开(公告)号：US4201845A

公开(公告)日：1980-05-06

申请号：US875464

申请日：1978-02-06

Applicant: Joseph Feder ,  Katharine Ku ,  Mau-Jung Ku

Inventor： Joseph Feder ,  Katharine Ku ,  Mau-Jung Ku

IPC: C12M3/06 ,  C12K9/00 ,  C12B1/10

CPC classification number: C12M29/16 ,  C12M23/12 ,  C12M23/48 ,  C12M25/10 ,  C12M29/04 ,  C12M29/10 ,  C12M41/14

Abstract: A cell culture reactor is provided for the growth of cells in vitro which employs elongate, selectively permeable hollow fibers arranged in a shallow layer configuration as a matrix for cell attachment on the outer surface of the fibers, and aeration of the cells by passage through the interior of said fibers and permeation of the membrane cell. The flow path of the culture media is directed by distributor plate means substantially uniformly through the fiber layer and substantially transverse to the plane of the elongate axes of the fibers.

Abstract translation: 提供了用于体外细胞生长的细胞培养反应器，其使用以浅层构型布置的细长的，选择性可渗透的中空纤维作为纤维外表面上的细胞附着的基质，并且通过通过 所述纤维的内部和膜细胞的渗透。 培养基的流动路径由分配器板装置基本上均匀地通过纤维层并且基本上横向于纤维的细长轴的平面。