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公开(公告)号：US4087327A
公开(公告)日：1978-05-02
申请号：US676100
申请日：1976-04-12
Applicant: Joseph Feder , Katharine Ku , Mau-Jung Kuo
Inventor： Joseph Feder , Katharine Ku , Mau-Jung Kuo
Abstract: A cell culture reactor system is provided for the growth of cells in vitro which employs elongate hollow or solid fibers arranged in a shallow layer configuration as a matrix for cell attachment in which the flow path of the culture media is directed substantially uniformly through the fiber layer and substantially transverse to the plane of the elongate axes of the fibers.
Abstract translation: 提供细胞培养反应器系统用于体外细胞的生长，其采用以浅层构型布置的细长的中空或固体纤维作为细胞附着的基质，其中培养基的流动路径基本均匀地通过纤维层 并且基本上横向于纤维的细长轴的平面。
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公开(公告)号：US4210719A
公开(公告)日：1980-07-01
申请号：US974407
申请日：1978-12-29
Applicant: William R. Tolbert , Joseph Feder , Mau-Jung Kuo
Inventor： William R. Tolbert , Joseph Feder , Mau-Jung Kuo
IPC: C12P1/00
CPC classification number: C12P1/00 , Y10S435/948
Abstract: Process for the production of human TAF in vitro comprising growing the human rhabdomyosarcoma cell line RD in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.
Abstract translation: 用于在体外生产人TAF的方法包括在约35-38℃的营养培养基的搅拌的液体悬浮液中培养人横纹肌肉瘤细胞系RD足够的时间以制备TAF并从细胞中回收所得TAF 或细胞产物。
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公开(公告)号：US4209587A
公开(公告)日：1980-06-24
申请号：US974408
申请日：1978-12-29
Applicant: William R. Tolbert , Joseph Feder , Mau-Jung Kuo
Inventor： William R. Tolbert , Joseph Feder , Mau-Jung Kuo
IPC: C07K14/47 , C07K14/515 , C12P1/00
CPC classification number: C07K14/4748 , C07K14/515 , Y10S435/948
Abstract: Process for the production of human TAF in vitro comprising growing the human liver adenocardinoma cell line SK-HEP-1 in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.
Abstract translation: 在体外制备人TAF的方法，包括在约35-38℃的营养培养基的搅拌的液体悬浮液中培养人肝腺癌细胞系SK-HEP-1足够的时间来制备TAF并回收 从细胞或细胞产物得到TAF。
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公开(公告)号：US4268629A
公开(公告)日：1981-05-19
申请号：US126811
申请日：1980-03-03
Applicant: William R. Tolbert , Mau-Jung Kuo , Joseph Feder
Inventor： William R. Tolbert , Mau-Jung Kuo , Joseph Feder
IPC: C12P1/00
CPC classification number: C12P1/00 , Y10S435/948
Abstract: Process for the production of human angiogenic factor in vitro comprising growing the human diploid cell line IMR-90 on support surface in nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate angiogenic factor and recovering the resulting angiogenic factor from the cells or cell product.
Abstract translation: 用于在体外生产人血管生成因子的方法，包括在约35-38℃下在营养培养基中的载体表面上培养人二倍体细胞系IMR-90足够的时间以制备血管生成因子并回收所得的血管生成因子 从细胞或细胞产物。
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公开(公告)号：US4210718A
公开(公告)日：1980-07-01
申请号：US974403
申请日：1978-12-29
Applicant: William R. Tolbert , Joseph Feder , Mau-Jung Kuo
Inventor： William R. Tolbert , Joseph Feder , Mau-Jung Kuo
IPC: C07K14/47 , C07K14/515 , C12P1/00
CPC classification number: C07K14/515 , C07K14/4748 , Y10S435/948
Abstract: Process for the production of human TAF in vitro comprising growing the human melanoma cell line A-375 in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.
Abstract translation: 用于在体外生产人TAF的方法包括在约35-38℃的营养培养基的搅拌的液体悬浮液中培养人黑素瘤细胞系A-375足够的时间以制备TAF并从所得的TAF中回收所得的TAF 细胞或细胞产物。
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Patent Agency Ranking
公开(公告)号：US4229531A
公开(公告)日：1980-10-21
申请号：US974404
申请日：1978-12-29
Applicant: William R. Tolbert , Joseph Feder , Mau-Jung Kuo
Inventor： William R. Tolbert , Joseph Feder , Mau-Jung Kuo
IPC: C12P1/00
CPC classification number: C12P1/00 , Y10S435/948
Abstract: Process for the production of human TAF in vitro comprising growing the human colon adenocarcinoma cell line HT-29 in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.
Abstract translation: 用于在体外制备人TAF的方法包括在约35-38℃的营养培养基的搅拌的液体悬浮液中培养人结肠腺癌细胞系HT-29足够的时间以制备TAF并回收所得到的TAF 从细胞或细胞产物。
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公开(公告)号：US4225670A
公开(公告)日：1980-09-30
申请号：US974405
申请日：1978-12-29
Applicant: William R. Tolbert , Joseph Feder , Mau-Jung Kuo
Inventor： William R. Tolbert , Joseph Feder , Mau-Jung Kuo
IPC: C12P1/00
CPC classification number: C12P1/00 , Y10S435/811 , Y10S435/948
Abstract: Process for the production of human TAF in vitro comprising growing the human Burkitt lymphoma cell line Raji in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.
Abstract translation: 用于在体外生产人TAF的方法包括在约35-38℃下在营养培养基的搅拌的液体悬浮液中培养人类伯基特淋巴瘤细胞系Raji足够的时间以制备TAF并从 细胞或细胞产物。
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公开(公告)号：US4217412A
公开(公告)日：1980-08-12
申请号：US33274
申请日：1979-04-25
Applicant: William R. Tolbert , Joseph Feder , Mau-Jung Kuo , Moses J. Folkman
Inventor： William R. Tolbert , Joseph Feder , Mau-Jung Kuo , Moses J. Folkman
IPC: C07K14/47 , C07K14/515 , C12P21/00
CPC classification number: C07K14/515 , C07K14/4748 , Y10S435/948
Abstract: Process for the production of human TAF in vitro comprising growing the human medulloblastoma cell line TE-671 in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.
Abstract translation: 在体外制备人TAF的方法，包括在约35-38℃的营养培养基搅拌的液体悬浮液中培养人髓母细胞瘤细胞系TE-671足够的时间以制备TAF并从所得的TAF中回收所得的TAF 细胞或细胞产物。
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公开(公告)号：US4190708A
公开(公告)日：1980-02-26
申请号：US909137
申请日：1978-05-24
Applicant: Mau-Jung Kuo , Margaret J. Reents , Joseph Feder
Inventor： Mau-Jung Kuo , Margaret J. Reents , Joseph Feder
CPC classification number: C12N9/6462 , C12Y304/21073
Abstract: The yield of urokinase produced by cell culture of kidney cells is improved by incorporating in the cell culture medium an elevated level of phenylalanine.
Abstract translation: 通过在细胞培养基中掺入升高水平的苯丙氨酸来改善肾细胞细胞培养产生的尿激酶的产量。
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公开(公告)号：US4266032A
公开(公告)日：1981-05-05
申请号：US65652
申请日：1979-08-10
Applicant: Robert E. Miller , Mau-Jung Kuo , Charles Lewis, Jr.
Inventor： Robert E. Miller , Mau-Jung Kuo , Charles Lewis, Jr.
CPC classification number: C12N5/0075 , C12M25/16 , C12N2533/30
Abstract: A method of submerged cell culture is provided which employs a microcarrier support comprising cross-linked polystyrene resin beads derivatized with amino acids, peptides, or hydroxy carboxylic acids.
Abstract translation: 提供了一种浸没式细胞培养方法，其采用包含用氨基酸，肽或羟基羧酸衍生化的交联聚苯乙烯树脂珠的微载体载体。
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