摘要:
2-[(4-Benzyl)-1-piperidinyl)-methyl]benzimidazole-5-ol derivatives are NMDA NR2B receptor antagonists useful in the treatment of pain and other NMDA mediated diseases.
摘要:
Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are effective as NMD NR2B antagonists useful for treating conditions such as, for example, Parkinson's disease, Alzheimer's disease, migraine, epilepsy and pain.
摘要:
The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
摘要:
Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are effective as NMDA/NR2B antagonists useful for treating neurological conditions such as, for example, pain, Parkinson's disease, Alzheimer's disease, epilepsy, depression, anxiety, ischemic brain injury including stroke, and other conditions.
摘要:
Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA/NR2B antagonists useful for treating neurological conditions such as, for example, pain, Parkinson's disease, Alzheimer's disease, epilepsy, depression, anxiety, ischemic brain injury including stroke, and other conditions.
摘要:
Load-bearing devices, each including an overload indicator of the present invention interconnecting load bearing connectors, preferably elongated load bearing connectors are provided. In preferred embodiments, the load bearing connectors are chains, ropes, wire ropes, cables, straps and the like, preferably chain. The overload indicator includes a link having a strand of wire form material. The strand of wire form material having first and second portions, the first portion having a first strength; the second portion including a weaker segment having a second strength which is less than the first strength. The weaker segment preferably has a generally predetermined load bearing capacity or capability and is calibrated to reduce the load bearing capacity or capability of the overload indicator. Methods of making an overload indicator and a load bearing device including an overload indicators of the present invention are also disclosed.
摘要:
A debarking chain having passing links; the passing links being substantially rounded in order to permit the passing links to pass through adjacent links such that the orientation of the passing link relative to its adjacent links can change at random in order to randomly distribute the wear and stress from the impact of adjacent or next to adjacent links on the passing links so that the overall wear life of the present debarking chain is extended over similar chain with elongated, oblong links of the prior art. The invention also includes a debarking drum having a plurality of debarking chains having at least one, preferably a plurality of passing links, as well as a debarking device having such a debarking drum. The debarking device preferably includes a chipping device and a method of using the same.
摘要:
Load-bearing devices, each including an overload indicator of the present invention interconnecting load bearing connectors, preferably elongated load bearing connectors are provided. In preferred embodiments, the load bearing connectors are chains, ropes, wire ropes, cables, straps and the like, preferably chain. The wire form overload indicator preferably includes a modified wire form link, preferably either a modified welded link or a modified quick link, generally having a first thickness and first and second elongated sides. The modified link preferably includes two elongated sides, one of which preferably has a portion having a diminished thickness narrower than the first thickness. The diminished thickness preferably has a generally predetermined load bearing capacity or capability and is calibrated to reduce the load bearing capacity or capability of the overload indicator. Methods of making an overload indicator and a load bearing device including an overload indicators of the present invention are also disclosed.
摘要:
Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B in antagonists. Also provided herein are processes for making compounds of Formula (I) and intermediate compounds.
摘要:
A safety chain assembly 24 for securing a towed agricultural vehicle (not shown) to a towing vehicle 21. The safety chain assembly 24 includes a clevis hook 54 having two pin receiving openings 55; a latch member 60 having an attachment opening 62; a spring pin assembly 56, and an elongated load bearing device 36 having a securing opening 37. In the preferred embodiment shown in the drawings the elongated load bearing device 36 is a chain, but it will be appreciated that it could also be a wire rope or other load bearing device having a securing opening 37. Similarly, the preferred spring pin assembly 56 includes a biasing mechanism such as a spring 64 and a washer 66; a retention member 70 and a pin 72; the pin 72 having an annular groove 84, a head 85 and first and second ends 87, 89; the annular groove 84 being located proximate the first end 87 and the head 85 being located proximate the second end 89. The elongated load bearing device 36, preferably the chain 36, and the latch member 60 are interconnected to the clevis hook 54 by the spring pin assembly 56; The retention member is preferably selected from the group consisting of a spring washer and a snap ring and is preferably a snap ring. Methods of attaching and securing the safety chain assembly are also disclosed.