公开(公告)号：US08158618B2

公开(公告)日：2012-04-17

申请号：US12487725

申请日：2009-06-19

申请人： Dean Brown ,  James R. Damewood ,  Phil Edwards ,  James Hulsizer ,  James Campbell Muir ,  M. Edward Pierson, Jr. ,  Ashokkumar Bhikkappa Shenvi ,  Steven Wesolowski ,  Dan Widzowski ,  Michael Wood

发明人： Dean Brown ,  James R. Damewood ,  Phil Edwards ,  James Hulsizer ,  James Campbell Muir ,  M. Edward Pierson, Jr. ,  Ashokkumar Bhikkappa Shenvi ,  Steven Wesolowski ,  Dan Widzowski ,  Michael Wood

IPC分类号： A61P25/00 ,  A61K31/554 ,  C07D281/02

CPC分类号： C07D417/04 ,  A61K31/554 ,  C07D281/16

摘要： Compounds the following formula: wherein Z is as described in the specification, pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of treating bipolar disorder, an anxiety disorder, a mood disorder or schizophrenia or other psychotic disorder with said compounds.

摘要翻译： 下式的化合物：其中Z如说明书中所述，其药学上可接受的盐，包含其的组合物，以及用所述化合物治疗双相性精神障碍，焦虑障碍，情绪障碍或精神分裂症或其它精神病症的方法。

公开(公告)号：US20090318415A1

公开(公告)日：2009-12-24

申请号：US12487725

申请日：2009-06-19

申请人： Dean Brown ,  James R. Damewood ,  Phil Edwards ,  James M. Hulsizer ,  James Campbell Muir ,  M. Edward Pierson, Jr. ,  Ashokkumar Bhikkappa Shenvi ,  Steven Wesolowski ,  Dan Widzowski ,  Michael Wood

发明人： Dean Brown ,  James R. Damewood ,  Phil Edwards ,  James M. Hulsizer ,  James Campbell Muir ,  M. Edward Pierson, Jr. ,  Ashokkumar Bhikkappa Shenvi ,  Steven Wesolowski ,  Dan Widzowski ,  Michael Wood

IPC分类号： A61K31/554 ,  C07D417/04 ,  A61P25/00

CPC分类号： C07D417/04 ,  A61K31/554 ,  C07D281/16

摘要： Compounds the following formula: wherein Z is as described in the specification, pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of treating bipolar disorder, an anxiety disorder, a mood disorder or schizophrenia or other psychotic disorder with said compounds.

摘要翻译： 下式的化合物：其中Z如说明书中所述，其药学上可接受的盐，包含其的组合物，以及用所述化合物治疗双相性精神障碍，焦虑障碍，情绪障碍或精神分裂症或其它精神病症的方法。

公开(公告)号：US20090170851A1

公开(公告)日：2009-07-02

申请号：US12403553

申请日：2009-03-13

申请人： Peter Bernstein ,  Daniel Hill ,  David Nugiel ,  Edward Pierson ,  Ashokkumar Shenvi ,  Robert Jacobs

发明人： Peter Bernstein ,  Daniel Hill ,  David Nugiel ,  Edward Pierson ,  Ashokkumar Shenvi ,  Robert Jacobs

IPC分类号： A61K31/5377 ,  A61P25/22

CPC分类号： C07D311/66

摘要： Compounds according to Formula (I): wherein R1, R2, R3, and R4 are as defined in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.

摘要翻译： 根据式（I）的化合物：其中R 1，R 2，R 3和R 4如本说明书中所定义，药学上可接受的盐，制备方法，药物组合物及其使用方法。

公开(公告)号：US20060178372A1

公开(公告)日：2006-08-10

申请号：US11397081

申请日：2006-04-04

申请人： Markus Haeberlein ,  Daniel Sohn ,  Marc Chapdelaine ,  Timothy Davenport ,  Carey Horchler ,  Edward Pierson ,  John McCauley

发明人： Markus Haeberlein ,  Daniel Sohn ,  Marc Chapdelaine ,  Timothy Davenport ,  Carey Horchler ,  Edward Pierson ,  John McCauley

IPC分类号： A61K31/496 ,  A61K31/4709 ,  C07D403/02 ,  C07D215/36

CPC分类号： C07D215/233 ,  C07D215/42 ,  C07D311/24 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D417/12 ,  Y02E60/324

摘要： Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.

摘要翻译： 本文提供具有式（I）的化合物：其中所述化合物可用于治疗精神障碍，包括但不限于抑郁症，广泛性焦虑症，进食障碍，痴呆症，惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病，心血管调节，运动障碍，内分泌障碍，血管痉挛和性功能障碍。 该化合物是5HT 1B和5HT 1D 1拮抗剂。

公开(公告)号：US07026314B2

公开(公告)日：2006-04-11

申请号：US10466449

申请日：2002-01-15

申请人： Marc Chapdelaine ,  Timothy Davenport ,  Markus Haeberlein ,  Carey Horchler ,  John McCauley ,  Edward Pierson ,  Daniel Sohn

发明人： Marc Chapdelaine ,  Timothy Davenport ,  Markus Haeberlein ,  Carey Horchler ,  John McCauley ,  Edward Pierson ,  Daniel Sohn

IPC分类号： C07D403/04 ,  C07D403/14 ,  A61K31/496 ,  A61P25/24 ,  A61P3/04

CPC分类号： C07D231/12 ,  C07D215/50 ,  C07D233/56 ,  C07D249/08 ,  C07D311/24 ,  C07D311/58 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D417/12

摘要： Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B antagonists. Also provided herein are processes for making compounds of Formula (I) and intermediate compounds.

摘要翻译： 本文提供了式（I）的化合物，其中所述化合物可用于治疗精神障碍，包括但不限于抑郁症，广泛性焦虑症，进食障碍，痴呆症，惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病，心血管调节，运动障碍，内分泌障碍，血管痉挛和性功能障碍。 该化合物是5HT 1 B 1拮抗剂。 本文还提供了制备式（I）化合物和中间体化合物的方法。

公开(公告)号：US20050009818A1

公开(公告)日：2005-01-13

申请号：US10889350

申请日：2004-07-12

申请人： Edward Pierson ,  Daniel Sohn ,  Markus Haeberlein ,  Timothy Davenport ,  Marc Chapdelaine ,  Carey Horchler ,  John McCauley

发明人： Edward Pierson ,  Daniel Sohn ,  Markus Haeberlein ,  Timothy Davenport ,  Marc Chapdelaine ,  Carey Horchler ,  John McCauley

IPC分类号： C07D215/48 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61P5/00 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D215/50 ,  C07D311/24 ,  C07D311/58 ,  C07D311/66 ,  C07D401/04 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  C07D521/00 ,  C07D417/14 ,  C07D413/14 ,  C07

CPC分类号： C07D231/12 ,  A61K31/495 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  C07D215/50 ,  C07D233/56 ,  C07D249/08 ,  C07D311/24 ,  C07D311/58 ,  C07D401/04 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D417/12

摘要： Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.

摘要翻译： 本文提供具有式（I）的化合物：其中所述化合物可用于治疗精神障碍，包括但不限于抑郁症，广泛性焦虑症，进食障碍，痴呆症，惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病，心血管调节，运动障碍，内分泌障碍，血管痉挛和性功能障碍。 这些化合物是5HT1B和5HT1D拮抗剂。

公开(公告)号：US20220000090A1

公开(公告)日：2022-01-06

申请号：US17481313

申请日：2021-09-22

申请人： Edward Pierson

发明人： Edward Pierson

IPC分类号： A01K97/08 ,  B65D85/30 ,  B65D55/02 ,  B65D43/16

摘要： A fishing rod case composed of impact resistant material which covers the central portion and tip of the shaft of the fishing rod while leaving the handle and reel exposed. The case has two sections connected by a hinge and a closing mechanism which removably joins the two sections together when the case is in a closed position. The two sections each have a rod enclosing cutout which are joined to create an opening that encloses the rod when the case is closed. The circular opening is larger than the shaft of the rod, but smaller than the guides attached to the rod. Since the guides cannot pass through the opening created by joining the two rod enclosing cutouts the case is retained in place when it comes into contact with one of the guides attached to the shaft and is prevented from sliding off the rod.

公开(公告)号：US20200154689A1

公开(公告)日：2020-05-21

申请号：US16193408

申请日：2018-11-16

申请人： Edward Pierson

发明人： Edward Pierson

IPC分类号： A01K97/08 ,  B65D43/16 ,  B65D55/02 ,  B65D85/30

摘要： A fishing rod case composed of impact resistant material which covers the central portion and tip of the shaft of the fishing rod while leaving the handle and reel exposed. The case has two sections connected by a hinge and a closing mechanism which removably joins the two sections together when the case is in a closed position. The two sections each have a rod enclosing cutout which are joined to create an opening that encloses the rod when the case is closed. The circular opening is larger than the shaft of the rod, but smaller than the guides attached to the rod. Since the guides cannot pass through the opening created by joining the two rod enclosing cutouts the case is retained in place when it comes into contact with one of the guides attached to the shaft and is prevented from sliding off the rod.

公开(公告)号：US20090004106A1

公开(公告)日：2009-01-01

申请号：US12278699

申请日：2007-02-14

申请人： John Richard Heys ,  Edward Pierson ,  William Potts

发明人： John Richard Heys ,  Edward Pierson ,  William Potts

IPC分类号： A61K51/04 ,  C07D413/14

CPC分类号： C07D413/12 ,  A61K51/0463 ,  C07B2200/05

摘要： The present invention provides novel radioligands for the 5-HT1B receptor of the formula I.

摘要翻译： 本发明提供了式I的5-HT1B受体的新型放射性配体。

公开(公告)号：US20080076759A1

公开(公告)日：2008-03-27

申请号：US11864102

申请日：2007-09-28

申请人： Edward Pierson ,  Daniel Sohn ,  Markus Haeberlein ,  Timothy Davenport ,  Marc Chapdelaine ,  Carey Horchler ,  John McCauley

发明人： Edward Pierson ,  Daniel Sohn ,  Markus Haeberlein ,  Timothy Davenport ,  Marc Chapdelaine ,  Carey Horchler ,  John McCauley

IPC分类号： A61K31/551 ,  A61K31/495 ,  A61K31/497 ,  A61P1/00 ,  A61P21/00 ,  A61P5/00 ,  A61P9/00 ,  A61P25/06 ,  A61P15/00 ,  A61K31/5377 ,  A61K31/541

CPC分类号： C07D231/12 ,  A61K31/495 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  C07D215/50 ,  C07D233/56 ,  C07D249/08 ,  C07D311/24 ,  C07D311/58 ,  C07D401/04 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D417/12

摘要： Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.

摘要翻译： 本文提供具有式（I）的化合物：其中所述化合物可用于治疗精神障碍，包括但不限于抑郁症，广泛性焦虑症，进食障碍，痴呆症，惊恐障碍和睡眠障碍。 该化合物还可用于治疗胃肠道疾病，心血管调节，运动障碍，内分泌障碍，血管痉挛和性功能障碍。 该化合物是5个HT 1B和5个HT 1D 1拮抗剂。