公开(公告)号：US09388250B2

公开(公告)日：2016-07-12

申请号：US13202919

申请日：2010-02-23

Applicant: Jochen Buck ,  Lonny Levin ,  Jonathan Zippin

Inventor： Jochen Buck ,  Lonny Levin ,  Jonathan Zippin

IPC: A61K31/427 ,  A61K31/4184 ,  A61K31/4152 ,  A61K31/4015 ,  A61K31/496 ,  A61K31/421 ,  C07K16/40

CPC classification number: C07K16/40 ,  A61K31/427

Abstract: Soluble adenylyl cyclase (sAC) is implicated in proliferation of keratinocytes. Inhibitors of sAC are useful for the treatment and/or prevention of psoriasis and other hyperproliferative skin disorders. Assays to identify such compounds are also described.

Abstract translation: 可溶性腺苷酸环化酶（sAC）涉及角质形成细胞的增殖。 sAC的抑制剂可用于治疗和/或预防牛皮癣和其它过度增生性皮肤病。 还描述了鉴定这些化合物的分析。

公开(公告)号：US20110305640A1

公开(公告)日：2011-12-15

申请号：US13202919

申请日：2010-02-23

Applicant: Jochen Buck ,  Lonny Levin ,  Jonathan Zippin

Inventor： Jochen Buck ,  Lonny Levin ,  Jonathan Zippin

IPC: A61K49/00 ,  C12Q1/00 ,  C12Q1/02 ,  A61K31/7088 ,  A61K31/496 ,  A61P17/00 ,  A61K31/421 ,  A61K31/4184 ,  A61K31/4025 ,  A61K31/4015 ,  A61P17/06 ,  A61K39/395 ,  A61K31/427

CPC classification number: C07K16/40 ,  A61K31/427

Abstract: Soluble adenylyl cyclase (sAC) is implicated in proliferation of keratinocytes. Inhibitors of sAC are useful for the treatment and/or prevention of psoriasis and other hyperproliferative skin disorders. Assays to identify such compounds are also described.

Abstract translation: 可溶性腺苷酸环化酶（sAC）涉及角质形成细胞的增殖。 sAC的抑制剂可用于治疗和/或预防牛皮癣和其它过度增生性皮肤病。 还描述了鉴定这些化合物的分析。

公开(公告)号：US09017681B2

公开(公告)日：2015-04-28

申请号：US12523011

申请日：2008-01-11

Applicant: Lonny Levin ,  Jochen Buck ,  Leo Brizuela ,  Michael Pinnisi

Inventor： Lonny Levin ,  Jochen Buck ,  Leo Brizuela ,  Michael Pinnisi

IPC: A61K31/122 ,  A61K31/415

CPC classification number: A61K31/415 ,  G01N2333/988 ,  G01N2500/00

Abstract: The present invention relates to a method of preventing or treating a disease caused by bacterial infection by administering an effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of bacterial adenylyl cyclase that do not substantially modulate adenylyl cyclase of the subject. The invention also provides methods for culturing bacterial pathogens and methods for inducing the pathogenic state in vitro.

Abstract translation: 本发明涉及通过施用有效量的细菌腺苷酸环化酶调节剂来预防或治疗由细菌感染引起的疾病的方法。 本发明还提供了可用于预防或治疗疾病的药物组合物，其中组合物含有治疗有效量的细菌腺苷酸环化酶调节剂。 本发明还提供了用于鉴定细菌腺苷酸环化酶的选择性调节剂的筛选方法，所述选择性调节剂基本上不调节受试者的腺苷酸环化酶。 本发明还提供培养细菌病原体的方法和在体外诱导致病状态的方法。

公开(公告)号：US09095578B2

公开(公告)日：2015-08-04

申请号：US12523019

申请日：2008-01-11

Applicant: Lonny Levin ,  Jochen Buck ,  Leo Brizuela ,  Michael Pinnisi

Inventor： Lonny Levin ,  Jochen Buck ,  Leo Brizuela ,  Michael Pinnisi

IPC: A61K31/4409 ,  A61K31/4184 ,  A61K31/045 ,  A61K31/4406

CPC classification number: A61K31/4184 ,  A61K31/045 ,  A61K31/4406 ,  Y02A50/491 ,  Y02A50/492

Abstract: The present invention relates to a method of preventing or treating a disease caused by infection by a eukaryotic pathogen, wherein the method comprises administering an effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of a eukaryotic pathogen's adenylyl cyclase that do not substantially modulate an adenylyl cyclase of the subject. The invention also provides methods for culturing eukaryotic pathogens and methods for inducing the pathogenic state in vitro.

Abstract translation: 本发明涉及一种预防或治疗由真核病原体感染引起的疾病的方法，其中所述方法包括施用有效量的真核病原体腺苷酸环化酶的调节剂。 本发明还提供了可用于预防或治疗疾病的药物组合物，其中组合物含有治疗有效量的真核病原体腺苷酸环化酶的调节剂。 本发明还提供了用于鉴定真核生物病原体腺苷酸环化酶的选择性调节剂的筛选方法，所述选择性调节剂基本上不调节受试者的腺苷酸环化酶。 本发明还提供培养真核病原体的方法和用于诱导体外致病状态的方法。

公开(公告)号：US20100168203A1

公开(公告)日：2010-07-01

申请号：US12523011

申请日：2008-01-11

Applicant: Lonny Levin ,  Jochen Buck ,  Leo Brizuela ,  Michael Pinnisi

Inventor： Lonny Levin ,  Jochen Buck ,  Leo Brizuela ,  Michael Pinnisi

IPC: A61K31/7088 ,  A61K31/4184 ,  A61K31/4439 ,  A61P31/04

CPC classification number: A61K31/415 ,  G01N2333/988 ,  G01N2500/00

Abstract: The present invention relates to a method of preventing or treating a disease caused by bacterial infection by administering an effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of bacterial adenylyl cyclase that do not substantially modulate adenylyl cyclase of the subject. The invention also provides methods for culturing bacterial pathogens and methods for inducing the pathogenic state in vitro.

Abstract translation: 本发明涉及通过施用有效量的细菌腺苷酸环化酶调节剂来预防或治疗由细菌感染引起的疾病的方法。 本发明还提供了可用于预防或治疗疾病的药物组合物，其中组合物含有治疗有效量的细菌腺苷酸环化酶调节剂。 本发明还提供了用于鉴定细菌腺苷酸环化酶的选择性调节剂的筛选方法，所述选择性调节剂基本上不调节受试者的腺苷酸环化酶。 本发明还提供培养细菌病原体的方法和在体外诱导致病状态的方法。

公开(公告)号：US20100063099A1

公开(公告)日：2010-03-11

申请号：US12523019

申请日：2008-01-11

Applicant: Lonny Levin ,  Jochen Buck ,  Leo Brizuela ,  Michael Pinnisi ,  Leo Brizuela ,  Michael Pinnisi

Inventor： Lonny Levin ,  Jochen Buck ,  Leo Brizuela ,  Michael Pinnisi ,  Leo Brizuela ,  Michael Pinnisi

IPC: A61K31/4409 ,  A61K31/4184 ,  A61P31/00

CPC classification number: A61K31/4184 ,  A61K31/045 ,  A61K31/4406 ,  Y02A50/491 ,  Y02A50/492

Abstract: The present invention relates to a method of preventing or treating a disease caused by infection by a eukaryotic pathogen, wherein the method comprises administering an effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of a eukaryotic pathogen's adenylyl cyclase that do not substantially modulate an adenylyl cyclase of the subject. The invention also provides methods for culturing eukaryotic pathogens and methods for inducing the pathogenic state in vitro.

Abstract translation: 本发明涉及一种预防或治疗由真核病原体感染引起的疾病的方法，其中所述方法包括施用有效量的真核病原体腺苷酸环化酶的调节剂。 本发明还提供了可用于预防或治疗疾病的药物组合物，其中组合物含有治疗有效量的真核病原体腺苷酸环化酶的调节剂。 本发明还提供了用于鉴定真核生物病原体腺苷酸环化酶的选择性调节剂的筛选方法，所述选择性调节剂基本上不调节受试者的腺苷酸环化酶。 本发明还提供培养真核病原体的方法和用于诱导体外致病状态的方法。

公开(公告)号：US20070244174A1

公开(公告)日：2007-10-18

申请号：US10586929

申请日：2005-01-20

Applicant: Jochen Buck ,  Lonny Levin ,  Fritz Muhlschlegel

Inventor： Jochen Buck ,  Lonny Levin ,  Fritz Muhlschlegel

IPC: A61K31/4184 ,  G01N33/53

CPC classification number: A61K31/415 ,  A61K31/4184 ,  C12Q1/527 ,  G01N2333/988 ,  Y02A50/411

Abstract: The present invention relates to a method of treating a disorder mediated by soluble adenylyl cyclase in a subject. The method involves administering to a subject an effective amount of a compound disclosed herein that modulates soluble adenylyl cyclase, under conditions effective to treat the disorder mediated by soluble adenylyl cyclase. The present invention also relates to a method of treating a disorder mediated by soluble adenylyl cyclase in a subject, where the disorder is selected from the group consisting of: learning or memory disorders, malaria, fungal infection, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, and peripheral neuropathy. The method involves modulating soluble adenylyl cyclase in the subject. Another aspect of the present invention relates to a method of modulating soluble adenylyl cyclase. The method involves contacting eukaryotic cells with a compound that modulates soluble adenylyl cyclase, under conditions effective to modulate soluble adenylyl cyclase.

Abstract translation: 本发明涉及治疗受试者中由可溶性腺苷酸环化酶介导的病症的方法。 该方法涉及在有效治疗可溶性腺苷酰环化酶介导的病症的条件下，向受试者施用有效量的本文公开的调节可溶性腺苷酰环化酶的化合物。 本发明还涉及一种治疗受试者中由可溶性腺苷酸环化酶介导的病症的方法，其中所述病症选自：学习或记忆障碍，疟疾，真菌感染，脊髓损伤，阿尔茨海默病，肌萎缩症 侧索硬化和周围神经病变。 该方法涉及调节受试者中的可溶性腺苷酸环化酶。 本发明的另一方面涉及调节可溶性腺苷酸环化酶的方法。 该方法涉及在有效调节可溶性腺苷酸环化酶的条件下，将真核细胞与调节可溶性腺苷酸环化酶的化合物接触。