公开(公告)号：US20250154494A1

公开(公告)日：2025-05-15

申请号：US18708079

申请日：2022-11-08

Applicant: JANSSEN BIOTECH, INC.

Inventor： Nathan Felix ,  John M. Lindner ,  Kristina Kromer ,  Constantin Diekmann ,  Yonatan Herzig ,  Veronica Pinamonti ,  Miguel A. Hernandez ,  Miray Cetin ,  Jing Zhang ,  Laura Fisch

IPC: C12N15/10 ,  C07K16/28 ,  C12M1/00 ,  C12M1/12 ,  C12M3/06 ,  C12N5/0781 ,  C12N5/0783 ,  G01N33/566

Abstract: The present invention provides a platform for co-culturing T cells with APC cells expressing a library of antigenic sequences is disclosed, as well as compositions for use in the system, a co-culturing device and methods of use of the system for identifying novel T cell receptor:antigen interactions. The present invention also provides microfluidic co-encapsulation devices configured to generate longitudinal flows of individual particles (such as individual cells) from fluid particle suspensions, combining two or more individual particle flows into a single stream of individual particles, and segmenting the single stream using an isolation fluid, resulting in a suspension of co-encapsulated individual particles from each fluid particle suspension. The present invention also provides methods of using the microfluidic co-encapsulation devices and methods of modifying fluid particle suspensions to promote individual particle separation.

公开(公告)号：US20190048089A1

公开(公告)日：2019-02-14

申请号：US15763673

申请日：2016-09-30

Applicant: Janssen Biotech, Inc.

Inventor： Holger Babbe ,  Nathan Felix ,  Johan Fransson ,  Paul Kim ,  Michael Scully ,  Hong Zhou

IPC: C07K16/28 ,  C07K16/46 ,  A61K47/68 ,  A61K45/06 ,  C07K16/42 ,  A61K39/395

Abstract: The present invention relates to antagonistic antibodies specifically binding human CD40, polynucleotides encoding the antibodies or antigen-binding fragments thereof, and methods of making and using the foregoing.