公开(公告)号：US20240262900A1

公开(公告)日：2024-08-08

申请号：US18567197

申请日：2022-06-06

Applicant: JANSSEN BIOTECH, INC. ,  The Broad Institute, Inc. ,  The General Hospital Corporation

Inventor： Nathan Majewski ,  Ramnik Xavier ,  Thomas Sundberg ,  Gaochao Tian ,  Kyunghye Ahn Wisner ,  Holger Babbe

IPC: C07K16/18 ,  C07K1/22 ,  G01N33/68

CPC classification number: C07K16/18 ,  C07K1/22 ,  G01N33/6854 ,  G01N2440/14

Abstract: The present invention provides antigen binding domains that bind phosphorylated versions of CREB-regulated transcription coactivator 3 (CRTC3), polynucleotides encoding them, vectors, host cells, and methods of making and using them.

公开(公告)号：US20190048089A1

公开(公告)日：2019-02-14

申请号：US15763673

申请日：2016-09-30

Applicant: Janssen Biotech, Inc.

Inventor： Holger Babbe ,  Nathan Felix ,  Johan Fransson ,  Paul Kim ,  Michael Scully ,  Hong Zhou

IPC: C07K16/28 ,  C07K16/46 ,  A61K47/68 ,  A61K45/06 ,  C07K16/42 ,  A61K39/395

Abstract: The present invention relates to antagonistic antibodies specifically binding human CD40, polynucleotides encoding the antibodies or antigen-binding fragments thereof, and methods of making and using the foregoing.