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公开(公告)号：US5785044A
公开(公告)日：1998-07-28
申请号：US634521
申请日：1996-04-18
Applicant: James W. Meador , Thomas L. Kraft , David O'Bryan , John F. Berry , Thomas G. Miller , Norman Hugh Smith , William S. Schnorr , Christopher T. Nikirk , Louis A. Waters, Jr. , Sean M. Donnelly
Inventor： James W. Meador , Thomas L. Kraft , David O'Bryan , John F. Berry , Thomas G. Miller , Norman Hugh Smith , William S. Schnorr , Christopher T. Nikirk , Louis A. Waters, Jr. , Sean M. Donnelly
CPC classification number: A61B10/007 , A61B2010/0009
Abstract: A fluid sample receptacle provides a means of assuring uncontaminated, multiple samples of a fluid specimen. An upper or isolated sample chamber and a lower or primary sample chamber provide redundant test samples. A cover or lid with a downwardly extending column includes a stopper with a removable plug attached to automatically seal the lower sample chamber when the cover is sealed across the top of the upper chamber. This feature guarantees that the sample chambers are sealed or isolated simultaneously and that the test samples are therefore identical when taken. Tamper evident seals prove that either sample has not been contaminated. A preferred embodiment provides a bellows assembly to accommodate variations in ambient pressure and to provide a positive means of expelling a precise quantity of fluid from the receptacle for testing.
Abstract translation: 流体样品容器提供了确保未受污染的多个样品的流体样本的方法。 上或隔离的样品室和下或初级样品室提供冗余测试样品。 具有向下延伸的柱的盖子或盖子包括具有可拆卸塞子的塞子，当可拆卸盖子被封闭在上部腔室的顶部时，该塞子被附接以自动密封下部样品室。 该特征保证样品室被同时密封或隔离，因此测试样品在使用时是相同的。 篡改明显的密封件证明任一样品未被污染。 一个优选实施例提供了一种波纹管组件，以适应环境压力的变化，并且提供从该容器排出精确量的流体用于测试的积极手段。
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公开(公告)号：US5549141A
公开(公告)日：1996-08-27
申请号：US276892
申请日：1994-07-19
Applicant: James W. Meador , Thomas L. Kraft , Thomas G. Miller
Inventor： James W. Meador , Thomas L. Kraft , Thomas G. Miller
CPC classification number: B01L3/505 , G01N2001/007 , G01N35/1095 , Y10T436/2575
Abstract: A method for dispensing a sample of liquid from a sealed thermoplastic container which includes both a volumetrically flexible chamber holding the liquid and also a plurality of spaced axially vertical nozzles on the container underside, the nozzles having an inlet in fluid communication with the chamber. The container is first manipulated to increase the volume of the chamber, rotated from a right side up position to an upside down position, and after the two preceding operations an axial opening is non-invasively created in the nozzle while the container is upside down without decreasing the volume of the chamber. The container is then rotated from the upside down position to a right side up position without decreasing the volume of the chamber, manipulated to decrease the volume of the chamber and expel a sample of the liquid from the chamber through the nozzle opening, then rotated to an upside down position and the opening in the nozzle is closed by melting and clamping it closed.
Abstract translation: 一种用于从密封的热塑性容器分配液体样品的方法，其包括容纳液体的容积灵活的腔室和容器下侧上的多个间隔开的轴向垂直喷嘴，所述喷嘴具有与腔室流体连通的入口。 首先操作容器以增加从右侧向上位置向上颠倒位置旋转的腔室的体积，并且在两个先前的操作之后，在容器被倒置的同时在喷嘴中非侵入性地产生轴向开口而没有 减小腔室的体积。 然后将容器从倒置位置旋转到右侧向上位置，而不会减小腔室的体积，进行操作以减小腔室的体积，并通过喷嘴孔将来自腔室的液体样品排出，然后旋转至 上下颠倒的位置，并且喷嘴中的开口通过熔化和夹紧而关闭。
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公开(公告)号：US5169602A
公开(公告)日：1992-12-08
申请号：US490051
申请日：1990-03-07
Applicant: Wing S. Pang , Thomas L. Kraft , James W. Meador
Inventor： Wing S. Pang , Thomas L. Kraft , James W. Meador
CPC classification number: G01N35/1079 , A61J1/20 , A61J2200/10 , Y10S215/03
Abstract: A resealable conduit is used to remove or add fluid to a closed system without coring or contamination of the fluid. The conduit can include funnel-shaped guide means, duck bill valve means and beveled tip puncturing means. A conduit resting angle of less than about five degrees can be achieved. A tip bevel angle between about ten and twenty degrees is preferred. The beveled tip can have a rotated or twisted blade surface extension. A blade surface extension formed with a ninety degree rotation of the blade surface is preferred. Alternately, the puncturing means can include a needle point or a flat cutting surface.
Abstract translation: 可重新密封的管道用于将流体移除或添加到封闭系统中，而不会使流体取向或污染。 导管可以包括漏斗形引导装置，鸭嘴阀装置和斜角尖端穿刺装置。 可以实现小于约5度的管道静止角度。 优选约十到二十度之间的尖端斜角。 斜面尖端可以具有旋转或扭曲的叶片表面延伸。 优选地，叶片表面延伸形成有叶片表面的九十度旋转。 或者，穿刺装置可以包括针尖或平切面。
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公开(公告)号：US5883806A
公开(公告)日：1999-03-16
申请号：US725078
申请日：1996-10-02
Applicant: James W. Meador , Thomas L. Kraft
Inventor： James W. Meador , Thomas L. Kraft
CPC classification number: A61G12/001 , A61J7/0084 , G07F17/0092
Abstract: A container for pharmaceutical items, comprising a tray having at least one compartment adapted to retrievably contain at least one pharmaceutical item, each said compartment having associated therewith a lid movable between a closed position restricting access to the associated compartment and an open position permitting access to the associated compartment, and each lid having associated therewith a mechanism responsive to control signals from a computer to permit movement between the closed and open positions. The invention also includes a system for dispensing pharmaceutical items comprising at least one support structure supporting at least one drawer, each said drawer being adapted to receive at least one of the above described containers and being movable with respect to said support structure between an open position permitting access to a given compartment of a given container and a closed position restricting access to all containers in each said drawer; and at least one said computer operable to control access to each compartment in each container. The invention also includes a method of controllably and securably dispensing pharmaceutical items comprising, storing pharmaceutical items in locations identifiable by a computer and to which access is controlled by a computer, inputting data identifying a desired pharmaceutical item, and having said computer identify a location having the desired item and issue appropriate control signals to permit access to the desired item.
Abstract translation: 一种用于药物的容器，包括具有至少一个隔间的托盘，所述隔间适于可回收地容纳至少一个药物物品，每个所述隔室具有与其相关联的盖子，该盖子可在限制进入相关隔间的关闭位置和允许进入 相关联的隔室，并且每个盖具有与其相关联的机构，其响应于来自计算机的控制信号，以允许在关闭位置和打开位置之间移动。 本发明还包括用于分配药物物品的系统，该系统包括支撑至少一个抽屉的至少一个支撑结构，每个所述抽屉适于容纳上述容器中的至少一个并且能够相对于所述支撑结构在打开位置 允许进入给定容器的给定隔间和限制进入每个所述抽屉中的所有容器的关闭位置; 并且至少一个所述计算机可操作以控制对每个容器中每个隔室的通路。 本发明还包括可控地和可靠地分配药物物品的方法，包括：将药物物品存储在由计算机识别的位置中，并且由计算机控制哪个进入，输入标识期望的药物物品的数据，并使所述计算机识别具有 并且发出适当的控制信号以允许访问期望的项目。
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公开(公告)号：US5213232A
公开(公告)日：1993-05-25
申请号：US849513
申请日：1992-03-11
Applicant: Thomas L. Kraft , James W. Meador , John F. Berry , Lisa W. Rogers
Inventor： Thomas L. Kraft , James W. Meador , John F. Berry , Lisa W. Rogers
CPC classification number: B65D83/0409 , A61J7/0076 , B65D2583/049
Abstract: An apparatus for dispensing single homogeneous units upon rotation of the apparatus comprising a generally circular walled container having a bottom for holding the singular homogeneous units. A discharge area located distally from the bottom for receiving the single homogeneous units and for discharging them upon rotation of the apparatus. A helical spiraled rib member located on the generally circular walled container extending from the bottom of the container and along the circular walls of the container for creating during rotation a continuously variable inclined surface along the helical spiraled rib member and the circular walls of the container for advancing single homogeneous units along said helical spiralled rib member and the generally circular walls of the container until a single homogeneous unit reaches the discharge area for discharge from the container. The helical spiraled rib member has a helix depth from the circular wall of the container sufficient for advancing only a single homogeneous unit along the helical spiraled rib member and the generally circular wall of the container until a single homogeneous unit reaches the discharge area. The helical spiralled rib member has a helix angle sufficient relative to the length of the generally circular walled container from the bottom to the discharge area for creating during rotation a sufficient inclined surface for advancing single homogeneous units to the discharge area. Further, this invention provides removable caps which are used to seal these containers from the ambient environment when not being used for dispensing of single homogeneous units.
Abstract translation: 一种用于在设备旋转时分配单个均匀单元的装置，包括具有用于保持单个均匀单元的底部的大致圆形的壁形容器。 位于远离底部的用于接收单个均质单元并在设备旋转时将其排出的排放区域。 位于大致圆形壁状容器上的螺旋形螺旋形肋构件，其从容器的底部并沿着容器的圆形壁延伸，用于在旋转期间沿着螺旋形螺旋形肋构件和容器的圆形壁形成连续可变的倾斜表面， 沿着所述螺旋形螺旋状肋构件和容器的大致圆形壁推进单个均质单元，直到单个均匀单元到达排放区域以从容器排出。 螺旋状的螺旋肋构件具有从容器的圆形壁的螺旋深度，足以使螺旋形螺旋形肋构件和容器的大致圆形的壁前进仅一个均质单元，直到单个均匀单元到达排放区域。 螺旋形螺旋肋构件具有相对于从底部到排放区域的大致圆形壁容器的长度的足够的螺旋角，用于在旋转期间产生用于将单个均匀单元推进到排放区域的足够的倾斜表面。 此外，本发明提供了可拆卸盖，当不用于分配单个均匀单元时，该盖可用于将这些容器与环境环境密封。
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Patent Agency Ranking
公开(公告)号：US4819657A
公开(公告)日：1989-04-11
申请号：US60974
申请日：1987-06-16
Applicant: Thomas L. Kraft , Howard A. Vick , James W. Meador
Inventor： Thomas L. Kraft , Howard A. Vick , James W. Meador
Abstract: Disclosed herein is an automatic allergy testing system. The system includes an electrode capable of testing up to eight different allergies and an associated electronic unit. The electrode includes apparatus to transcutaneously deliver an allergen to the patient without puncturing the patient's skin. The electrode also includes a temperature sensor for sensing the skin temperature in the area surrounding the delivery of the allergen. Electronic apparatus is provided for processing the sensed temperature and storing data related thereto for subsequent print out to an output device. The allergy testing system is controlled so that periodic temperature readings are made at thrity second intervals over approximately a fifteen minute testing span. The data can be printed out in a graphic format to allow the physician to easily and quickly make more accurate diagnosis.
Abstract translation: 本文公开了一种自动过敏测试系统。 该系统包括能够测试多达八种不同过敏症的电极和相关联的电子单元。 电极包括用于经皮地将变应原递送给患者而不刺穿患者皮肤的装置。 电极还包括温度传感器，用于感测围绕过敏原递送区域的皮肤温度。 提供电子设备用于处理所感测到的温度并存储与之相关的数据以便随后打印输出到输出设备。 控制过敏测试系统，以便在大约十五分钟的测试范围内，以大量的第二间隔进行周期性温度读数。 数据可以以图形格式打印出来，使医生能够轻松，快速地做出更准确的诊断。
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公开(公告)号：US4488812A
公开(公告)日：1984-12-18
申请号：US268205
申请日：1981-05-29
Applicant: Thomas L. Kraft , Howard A. Vick , James W. Meador
Inventor： Thomas L. Kraft , Howard A. Vick , James W. Meador
Abstract: A photometric analyzer and method are disclosed for analyzing particle containing samples. More particularly, a nephelometric apparatus and method are disclosed for analyzing baceteria samples. In the disclosed embodiment, the bacteria count of a bacteria sample is determined by photometrically comparing the sample to another sample having a known particle or bacteria concentration. Thus, in accordance with the invention, samples having a known bacteria count may be quickly and easily obtained from a "go" "no-go" test. The bacteria samples obtained according to the invention may be used as standardized bacteria concentrations for conducting Kirby-Bauer dilution tests.
Abstract translation: 公开了用于分析含有颗粒的样品的光度分析仪和方法。 更具体地，公开了一种比浊法设备和方法，用于分析杆菌样品。 在所公开的实施方案中，细菌样品的细菌计数通过光学比较样品与具有已知颗粒或细菌浓度的另一样品而确定。 因此，根据本发明，具有已知细菌计数的样品可以从“去”“不进行”测试快速且容易地获得。 根据本发明获得的细菌样品可用作用于进行Kirby-Bauer稀释试验的标准细菌浓度。
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公开(公告)号：US4291983A
公开(公告)日：1981-09-29
申请号：US41475
申请日：1979-05-22
Applicant: Thomas L. Kraft , Howard A. Vick , James W. Meador
Inventor： Thomas L. Kraft , Howard A. Vick , James W. Meador
Abstract: A photometric analyzer and method are disclosed for analyzing particle containing samples. More particularly, a nephelometric apparatus and method are disclosed for analyzing bacteria samples. In the disclosed embodiment, the bacteria count of a bacteria sample is determined by photometrically comparting the sample to another sample having a known particle or bacteria concentration. Thus, in accordance with the invention, samples having a known bacteria count may be quickly and easily obtained from a "go" "no-go" test. The bacteria samples obtained according to the invention may be used as standardized bacteria concentrations for conducting Kirby-Bauer dilution tests.
Abstract translation: 公开了用于分析含有颗粒的样品的光度分析仪和方法。 更具体地，公开了一种比浊法装置和方法，用于分析细菌样品。 在所公开的实施方案中，细菌样品的细菌计数通过光学测量将样品分配到具有已知颗粒或细菌浓度的另一种样品来确定。 因此，根据本发明，具有已知细菌计数的样品可以从“去”“不进行”测试快速且容易地获得。 根据本发明获得的细菌样品可用作用于进行Kirby-Bauer稀释试验的标准细菌浓度。
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公开(公告)号：US4809707A
公开(公告)日：1989-03-07
申请号：US722772
申请日：1985-04-12
Applicant: Thomas L. Kraft , Howard A. Vick , James W. Meador , Corrine Johnson
Inventor： Thomas L. Kraft , Howard A. Vick , James W. Meador , Corrine Johnson
Abstract: Disclosed herein is an electrode for performing a plurality of allergy tests on a patient undergoing tests. The allergy electrode consists of a plurality of individual testing electrodes and a single common electrode. Each of the testing electrodes includes allergen delivery apparatus and a temperature sensor. The allergen is contained in a removable allergen impregnated pad. If a dry allergen is used, it may be hydrolized with a drop of distilled water prior to application. A small electric charge charges a charge plate on one side of the allergen pad and a common ring on the electrodes is grounded in circuit with the charging plate, thereby causing electric field to transfer the allergen through the pores of the skin. The area surrounding the allergen delivery area is sensed for temperature by a thin film temperature sensor and a rigid temperature conducted base. A thermistor or other temperature to voltage transducer converts the sensed temperature to an electric voltage which is applied through appropriate differential amplifiers and multiplexer to an analog to digital converter. The digital data is then stored by a microprocessor in random access memory. An output device can be connected to receive the stored data and the time at which it was stored so as to manifest to the physician the change in temperature of the tested area with respect to time.
Abstract translation: 本文公开了一种用于对正在进行测试的患者进行多次过敏试验的电极。 过敏电极由多个单独的测试电极和单个公共电极组成。 每个测试电极包括变应原递送装置和温度传感器。 过敏原包含在可移除过敏原浸渍垫中。 如果使用干性过敏原，可在使用前用一滴蒸馏水水解。 小电荷对变应原垫一侧的充电板充电，电极上的公共环与充电板接地，从而导致电场通过皮肤孔渗透过敏原。 通过薄膜温度传感器和刚性温度传导基座感测温度的变应原输送区域周围的区域。 热敏电阻或其他温度对电压传感器将感测到的温度转换成通过适当的差分放大器和多路复用器施加到模数转换器的电压。 然后，数字数据由微处理器存储在随机存取存储器中。 可以连接输出装置以接收所存储的数据及其存储时间，以便向医师显示测试区域相对于时间的温度变化。
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公开(公告)号：US4689303A
公开(公告)日：1987-08-25
申请号：US832997
申请日：1986-02-26
Applicant: Thomas L. Kraft , James W. Meador
Inventor： Thomas L. Kraft , James W. Meador
CPC classification number: C12M41/14 , B01L7/00 , C12M23/48 , Y10S435/809
Abstract: Described herein is a controlled circulation incubator device having a plurality of plate receiving trays held by a tray bracket. Heated air is circulated by a blower and heater assembly around the trays held by the tray bracket and the temperature of the flowing heated air is sensed by a thermister included in a temperature controller circuit. The termister is coupled in a circuit so that its resistance determines the amount of heating provided by the heater portion of the blower and heater assembly. Each of the trays have a front lid and a back lip and the plurality of trays are offset from one another within the confines of the incubator device. The angle of the back lip and the amount of offset are selected so that each of the back lips are positioned in a generally planar surface. This causes the front lip, which extend at a slight angle from the receiving trays, to extend into the circulating air stream and air is forced between adjacent trays to heat the contents held by the trays. At the backside of the trays a low pressure area appears, further forcing air across the trays. The package of the incubator is fabricated of metal to promote heat loss so that the heating means can more accurately control the temperature. A variable resistor is included to allow different temperatures to be selected.
Abstract translation: 本文描述了一种受控的循环培养器装置，其具有由盘支架保持的多个板容纳盘。 加热空气通过鼓风机和加热器组件围绕由托架托架保持的托盘循环，并且流动的加热空气的温度由包括在温度控制器电路中的热敏电阻感测。 触发器耦合在电路中，使得其电阻确定由鼓风机和加热器组件的加热器部分提供的加热量。 每个托盘具有前盖和后唇，并且多个托盘在培养箱装置的范围内彼此偏移。 选择后唇的角度和偏移量，使得每个后唇定位在大致平坦的表面中。 这使得从接收托盘延伸到微小角度的前唇延伸到循环空气流中，并且空气被迫在相邻托盘之间以加热由托盘保持的内容物。 在托盘的背面，出现低压区域，进一步迫使空气穿过托盘。 孵化器的包装由金属制成以促进热损失，使得加热装置可以更准确地控制温度。 包括一个可变电阻，可以选择不同的温度。
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