知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

42 records (took 0.03 seconds)

    Analyte detection system for multiple analytes
    2.
    发明申请
    Analyte detection system for multiple analytes 有权
    多种分析物的分析物检测系统

    公开(公告)号：US20060189858A1

    公开(公告)日：2006-08-24

    申请号：US11314176

    申请日：2005-12-21

    Applicant: Bernhard Sterling ,  James Braig ,  Kenneth Witte ,  Peter Rule ,  Richard Keenan ,  W. Hall

    Inventor： Bernhard Sterling ,  James Braig ,  Kenneth Witte ,  Peter Rule ,  Richard Keenan ,  W. Hall

    IPC: A61B5/00 ,  A61M31/00

    CPC classification number: A61M5/1723 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N1/14 ,  G01N21/05 ,  G01N21/274 ,  G01N21/35 ,  G01N2021/0346

    Abstract: An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.

    Abstract translation: 一种用于分析体液组成的装置。 该装置包括流体处理网络，其包括被配置为保持患者体内与体液的流体连通的患者端; 以及与所述流体处理网络操作地接合的泵单元。 泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过 病人结束 所述设备还包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。 在一个实施方案中，泵单元包括可在输液模式中操作但不在样品抽取模式中的第一泵，以及可在样品抽取模式中操作但不在输注模式中的第二泵。

    Sample element qualification
    3.
    发明申请
    Sample element qualification 审中-公开
    样品单元鉴定

    公开(公告)号：US20050036146A1

    公开(公告)日：2005-02-17

    申请号：US10824933

    申请日：2004-04-15

    Applicant: James Braig ,  Kenneth Witte ,  Philip Hartstein ,  Ken Li ,  Peter Rule

    Inventor： James Braig ,  Kenneth Witte ,  Philip Hartstein ,  Ken Li ,  Peter Rule

    IPC: G01N21/03 ,  G01N21/59 ,  G01N21/86 ,  G01N35/00 ,  G01N21/00

    CPC classification number: G01N35/00732 ,  G01N21/03 ,  G01N21/5907 ,  G01N21/8483 ,  G01N2035/00752 ,  G01N2035/00762 ,  G01N2035/00772 ,  G01N2035/00782

    Abstract: A sample element includes first and second substantially parallel faces separated by an intermediate member. The parallel faces and the intermediate member at least partially define a sample chamber configured to hold a volume of fluid. The sample element further includes an optical path extending through the parallel faces and the intermediate member, such that electromagnetic radiation can propagate through the sample chamber. The sample element further includes an identifying compound disposed within or on at least one of the parallel faces. The identifying compound has at least one indexed optical absorbance feature, such that spectral analysis of electromagnetic radiation propagated through the sample chamber yields the indexed optical absorbance feature. Detection of the indexed optical absorbance feature in electromagnetic radiation propagated through the sample chamber indicates to an analyte detection system whether the sample element is configured for use with the analyte detection system.

    Abstract translation: 样品元件包括由中间构件分隔开的第一和第二基本上平行的面。 平行面和中间构件至少部分地限定了构造成保持一定体积的流体的样品室。 样本元件还包括延伸穿过平行面和中间构件的光路，使得电磁辐射可以传播通过样品室。 样本元件还包括设置在至少一个平行面内或之中的识别化合物。 识别化合物具有至少一个索引的光吸收特征，使得通过样品室传播的电磁辐射的光谱分析产生索引的光吸收特征。 通过样品室传播的电磁辐射中的指示光吸收特征的检测表明分析物检测系统是否将样品元件配置为与分析物检测系统一起使用。

    Apparatus and methods for analyzing body fluid samples
    5.
    发明申请
    Apparatus and methods for analyzing body fluid samples 审中-公开

    公开(公告)号：US20070060872A1

    公开(公告)日：2007-03-15

    申请号：US11352956

    申请日：2006-02-13

    Applicant: W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    Inventor： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    IPC: A61M31/00 ,  A61B5/00 ,  A61D5/00

    CPC classification number: A61B5/14546 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M2230/20

    Abstract: An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength λ. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

    Apparatus and methods for analyzing body fluid samples
    6.
    发明申请
    Apparatus and methods for analyzing body fluid samples 审中-公开

    公开(公告)号：US20060189926A1

    公开(公告)日：2006-08-24

    申请号：US11316407

    申请日：2005-12-21

    Applicant: W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    Inventor： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    IPC: A61M31/00 ,  A61B5/00

    CPC classification number: A61B5/14546 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M2230/20

    Abstract: An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength B. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

    Analyte detection system with periodic sample draw and body fluid analyzer
    7.
    发明申请
    Analyte detection system with periodic sample draw and body fluid analyzer 审中-公开
    分析物检测系统，定期抽样和体液分析仪

    公开(公告)号：US20070179435A1

    公开(公告)日：2007-08-02

    申请号：US11316212

    申请日：2005-12-21

    Applicant: James Braig ,  Peter Rule

    Inventor： James Braig ,  Peter Rule

    IPC: A61M31/00 ,  G01N33/487 ,  A61B5/00

    CPC classification number: A61B5/1486 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61B2562/0295 ,  A61M5/14232 ,  A61M2005/1726 ,  A61M2230/201 ,  G01N27/3271 ,  G01N33/49

    Abstract: An embodiment of a system for analyzing a body fluid of a patient comprises a fluid transport network having a patient end configured to provide fluid communication with the body fluid in the patient and a fluid delivery point spaced from the patient end. A pump system is coupled to the fluid transport network. The pump system has an infusion mode in which the pump system is operable to pump an infusion fluid toward the patient end of the fluid transport network and a draw mode in which the pump system is operable to draw the body fluid from the patient into the fluid transport network through the patient end. At least one electrochemical test element is located near the fluid delivery point of the fluid transport network. The electrochemical test element is positioned to receive a portion of the body fluid delivered to the delivery point by the fluid transport network. An analyte detection system is configured to receive the test element and to measure at least one analyte in the portion of the body fluid.

    Abstract translation: 用于分析患者体液的系统的实施例包括流体输送网络，其具有构造成提供与患者体液的流体连通的患者端和与患者端间隔开的流体输送点。 泵系统耦合到流体输送网络。 泵系统具有输液模式，其中泵系统可操作以将输液流体朝向流体输送网络的患者端泵送，并且抽吸模式，其中泵系统可操作以将体液从患者吸入流体 运输网络通过病人端。 至少一个电化学测试元件位于流体输送网络的流体输送点附近。 电化学测试元件被定位成接收由流体输送网络输送到输送点的体液的一部分。 分析物检测系统被配置为接收测试元件并测量体液部分中的至少一种分析物。

    Layered spectroscopic sample element with microporous membrane
    9.
    发明申请
    Layered spectroscopic sample element with microporous membrane 审中-公开
    具有微孔膜的分层光谱样品元件

    公开(公告)号：US20060004267A1

    公开(公告)日：2006-01-05

    申请号：US11173768

    申请日：2005-07-01

    Applicant: Peter Rule ,  James Braig ,  Philip Hartstein

    Inventor： Peter Rule ,  James Braig ,  Philip Hartstein

    IPC: A61B5/00

    CPC classification number: B01L3/5023 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1491 ,  B01L3/5027 ,  B01L3/508 ,  B01L2200/027 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N21/03 ,  G01N21/8483 ,  G01N2021/0346

    Abstract: A spectroscopic sample holder comprises a microporous sheet. The microporous sheet has a top surface, a bottom surface substantially parallel to the top surface, and at least one side surface oriented substantially perpendicular to the top and bottom surfaces. The side surface forms an exposed transit opening configured to contact a material sample and distribute the contacted material sample into the microporous sheet. The spectroscopic sample holder further comprises a first planar support member positioned on, and substantially parallel to, the top surface of the microporous sheet. The spectroscopic sample holder further comprises a second planar support member positioned on the bottom surface of the microporous sheet, and oriented substantially parallel to the first planar support member.

    Abstract translation: 光谱样品架包括微孔片。 微孔片具有基本平行于顶表面的顶表面，底表面以及基本上垂直于顶表面和底表面取向的至少一个侧表面。 侧表面形成暴露的转移开口，其构造成接触材料样品并将接触的材料样品分配到微孔板中。 光谱样品架还包括位于微孔板的顶表面上且基本上平行于微孔板的顶表面的第一平面支撑构件。 光谱样品架还包括位于微孔板的底表面上并基本上平行于第一平面支撑构件定向的第二平面支撑构件。

    Near-patient module for analyte detection system
    10.
    发明申请
    Near-patient module for analyte detection system 审中-公开
    用于分析物检测系统的近距离模块

    公开(公告)号：US20070082342A1

    公开(公告)日：2007-04-12

    申请号：US11316681

    申请日：2005-12-21

    Applicant: James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    Inventor： James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    IPC: C12Q1/68 ,  C12M1/34

    CPC classification number: A61B5/14546 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61M5/14212 ,  A61M2230/20 ,  G01N35/1095

    Abstract: In certain embodiments, an apparatus for analyzing the composition of bodily fluid includes a first fluid passageway having a patient end which is configured to provide fluid communication with a bodily fluid within a patient. The apparatus further includes at least one pump coupled to the first fluid passageway. The at least one pump has an infusion mode in which the pump is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further includes an analyte detection system accessible via the first fluid passageway such that the analyte detection system can receive at least one component of the drawn sample of bodily fluid and determine a concentration of at least one analyte. The analyte detection system is spaced from the patient end of the first fluid passageway. The apparatus further includes a fluid sensor located at or near the patient end of the first fluid passageway and spaced from the analyte detection system. The fluid sensor is configured to sense a property of a fluid within the first fluid passageway.

    Abstract translation: 在某些实施例中，用于分析体液组成的装置包括具有患者端的第一流体通道，该患者端构造成提供与患者体内的体液的流体连通。 该装置还包括耦合到第一流体通道的至少一个泵。 所述至少一个泵具有输注模式，其中所述泵可操作以通过患者端向患者输送输注流体，以及抽样模式，其中所述泵可操作以从患者抽取体液样本通过 病人结束 该装置还包括可经由第一流体通道接近的分析物检测系统，使得分析物检测系统可以接收抽取的体液样本的至少一个组分并确定至少一种分析物的浓度。 分析物检测系统与第一流体通道的患者端隔开。 该装置还包括位于第一流体通道的患者端处或附近的流体传感器，并与分析物检测系统间隔开。 流体传感器构造成感测第一流体通道内的流体的性质。

Patent Agency Ranking