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公开(公告)号：US20240199644A1
公开(公告)日：2024-06-20
申请号：US18280487
申请日：2022-03-07
发明人： Huifeng HAN , Panliang GAO , Cunbo MA , Peng WANG , Wei LONG , Hao ZHANG , Lei ZHANG , Dan LIU
IPC分类号： C07D498/16 , A61K31/553 , C07D498/22 , C07D519/00
CPC分类号： C07D498/16 , A61K31/553 , C07D498/22 , C07D519/00
摘要： The invention relates to a KRAS G12D inhibitors of formula (I) or formula (IV), a composition containing the inhibitor and the use thereof
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公开(公告)号：US20230399297A1
公开(公告)日：2023-12-14
申请号：US18031893
申请日：2021-10-14
发明人： Runze LI , Cunbo MA , Zhenchang LIAN , Jing XIONG , Yanping WANG , Wei LONG
IPC分类号： C07D209/20 , C07C245/18 , C07D305/08 , C07D307/16 , C07D211/66 , C07D309/06 , C07D307/93 , C07D309/08 , C07D207/09 , C07D493/04 , C07D277/30 , C07D207/337 , C07D263/32 , C07D233/64 , C07D333/24 , C07D213/74 , C07D239/20 , C07D213/30 , C07D313/04 , C07D265/30 , C07D331/04 , A61P35/00
CPC分类号： C07D209/20 , C07C245/18 , C07D305/08 , C07D307/16 , C07D211/66 , C07D309/06 , C07D307/93 , C07D309/08 , C07D207/09 , C07D493/04 , C07D277/30 , C07D207/337 , C07D263/32 , C07D233/64 , C07D333/24 , C07D213/74 , C07D239/20 , C07D213/30 , C07D313/04 , C07D265/30 , C07D331/04 , A61P35/00 , C07C2601/18 , C07C2601/14 , C07C2601/16 , C07C2601/04 , C07C2601/02 , C07C2601/08
摘要： The invention relates to novel glutamine analogs, a composition containing the glutamine analogs and the use thereof.
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公开(公告)号：US20240336629A1
公开(公告)日：2024-10-10
申请号：US18276269
申请日：2022-01-26
发明人： Haijun LI , Mingming CHEN , Di KANG , Qinglong LI , Lei ZHANG , Man YAN , Wei LONG , Yanping WANG , Hao ZHANG , Cunbo MA , Amin LI
IPC分类号： C07D513/14 , C07D471/14 , C07D498/14 , C12N9/99
CPC分类号： C07D513/14 , C07D471/14 , C07D498/14 , C12N9/99
摘要： Provided are a compound of formula (I) that inhibit the activity of PARP7, a stereoisomer thereof, a deuterated derivative thereof, or a pharmaceutically acceptable salt thereof, an intermediate to prepare the compound, a process to prepare the compound, a composition comprising the same, and the methods of using the same.
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公开(公告)号：US20240059710A1
公开(公告)日：2024-02-22
申请号：US18037801
申请日：2021-11-19
发明人： Huifeng HAN , Panliang GAO , Wenlong ZHANG , Cunbo MA , Peng WANG , Dan LIU , Hao ZHANG , Wei LONG
IPC分类号： C07D519/00 , C07D487/08 , A61P35/00
CPC分类号： C07D519/00 , C07D487/08 , A61P35/00
摘要： KRAS G12D inhibitors of Formula (I), a composition containing the inhibitor and the use thereof.
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公开(公告)号：US20240025918A1
公开(公告)日：2024-01-25
申请号：US18037809
申请日：2021-11-19
发明人： Huifeng HAN , Panliang GAO , Wenlong ZHANG , Cunbo MA , Peng WANG , Dan LIU , Hao ZHANG , Wei LONG
IPC分类号： C07D519/00 , C07D487/08
CPC分类号： C07D519/00 , C07D487/08
摘要： Provided are KRAS G12D inhibitors of formula (I), a composition containing the inhibitors, a prodrug thereof, a PROTAC compound thereof and the use thereof.
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公开(公告)号：US20240199548A1
公开(公告)日：2024-06-20
申请号：US18283834
申请日：2022-03-25
发明人： Yang YE , Xiuwei LI , Guiqun YANG , Fashun YAN , Yanping WANG , Wei LONG
IPC分类号： C07D209/44 , A61K31/4035 , A61K31/437 , A61K45/06 , C07D471/04
CPC分类号： C07D209/44 , A61K31/4035 , A61K31/437 , A61K45/06 , C07D471/04
摘要： Compounds of general Formula S-1, S-2, S-3 and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.
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公开(公告)号：US20240116909A1
公开(公告)日：2024-04-11
申请号：US18284897
申请日：2022-03-29
发明人： Yang YE , Xiuwei LI , Guiqun YANG , Fashun YAN , Yanping WANG , Wei LONG
IPC分类号： C07D409/12 , C07D495/04 , C07D519/00 , C07D495/14 , C07D471/04
CPC分类号： C07D409/12 , C07D495/04 , C07D519/00 , C07D495/14 , C07D471/04
摘要： Compounds of general Formula I, II, III, IV, V and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.
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