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公开(公告)号：US20230128198A1
公开(公告)日：2023-04-27
申请号：US17794641
申请日：2021-01-22
发明人： Dai CHENG , Mingming CHEN , Amin LI , Haijun LI , Guiqun YANG
IPC分类号： C07D401/14 , C07D417/14 , C07D405/14 , C07D413/14 , C07D409/14 , C07D401/12
摘要： Provided are compounds of formula (I), or pharmaceutically acceptable salts thereof, which can be used for inhibiting the activity of Aurora A and treating cancer mediated by Aurora A.
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公开(公告)号：US11466005B2
公开(公告)日：2022-10-11
申请号：US17561381
申请日：2021-12-23
发明人： Haiquan Fang , Mingming Chen , Guiqun Yang , Yuelei Du , Yanping Wang , Tong Wu , Qinglong Li , Lei Zhang , Shaojing Hu
IPC分类号： C07D471/14 , A61K31/437 , A61P35/00
摘要： Disclosed are tricyclic compounds as bromodomain and extra-terminal (BET) inhibitors which are shown as formula I, their synthesis and their use for treating diseases. More particularly, disclosed are fused heterocyclic derivatives useful as inhibitors of BET, methods for producing such compounds and methods for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.
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公开(公告)号：US20220213109A1
公开(公告)日：2022-07-07
申请号：US17562492
申请日：2021-12-27
发明人： Amin LI , Sujing LI , Peng WANG , Chaojie DANG , Dan LIU
IPC分类号： C07D487/04 , A61P35/00 , A61K9/00
摘要： The invention relates to a KRAS mutant protein inhibitor shown as formula (I), a composition containing the inhibitor and the use thereof.
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公开(公告)号：US20220119386A1
公开(公告)日：2022-04-21
申请号：US17470572
申请日：2021-09-09
发明人： Hongwei YANG , Rui ZHOU , Liang ZHOU , Xin SUN
IPC分类号： C07D471/04 , A61P35/00 , C07D519/00
摘要： A compound represented by formula I or a pharmaceutically acceptable salt thereof and a use thereof in preparing a drug for treating, stopping or preventing a disease or disorder mediated by FGFR4 activity.
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公开(公告)号：US11136320B2
公开(公告)日：2021-10-05
申请号：US17315481
申请日：2021-05-10
发明人： Hongwei Yang , Rui Zhou , Liang Zhou , Xin Sun
IPC分类号： C07D471/04 , C07D519/00 , A61P35/00
摘要： A compound represented by formula I or a pharmaceutically acceptable salt thereof and a use thereof in preparing a drug for treating, stopping or preventing a disease or disorder mediated by FGFR4 activity.
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公开(公告)号：US10988466B2
公开(公告)日：2021-04-27
申请号：US16496655
申请日：2018-03-23
发明人： Cunbo Ma , Panliang Gao , Shaojing Hu , Zilong Xu , Huifeng Han , Xinping Wu , Di Kang
IPC分类号： C07D471/10 , C07D413/14 , C07D401/04 , C07D401/14 , C07D471/20 , C07D491/107 , C07D495/10 , C07D513/10
摘要： This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.
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公开(公告)号：US20240059710A1
公开(公告)日：2024-02-22
申请号：US18037801
申请日：2021-11-19
发明人： Huifeng HAN , Panliang GAO , Wenlong ZHANG , Cunbo MA , Peng WANG , Dan LIU , Hao ZHANG , Wei LONG
IPC分类号： C07D519/00 , C07D487/08 , A61P35/00
CPC分类号： C07D519/00 , C07D487/08 , A61P35/00
摘要： KRAS G12D inhibitors of Formula (I), a composition containing the inhibitor and the use thereof.
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公开(公告)号：US20240025918A1
公开(公告)日：2024-01-25
申请号：US18037809
申请日：2021-11-19
发明人： Huifeng HAN , Panliang GAO , Wenlong ZHANG , Cunbo MA , Peng WANG , Dan LIU , Hao ZHANG , Wei LONG
IPC分类号： C07D519/00 , C07D487/08
CPC分类号： C07D519/00 , C07D487/08
摘要： Provided are KRAS G12D inhibitors of formula (I), a composition containing the inhibitors, a prodrug thereof, a PROTAC compound thereof and the use thereof.
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公开(公告)号：US11345701B1
公开(公告)日：2022-05-31
申请号：US17407249
申请日：2021-08-20
发明人： Amin Li , Sujing Li , Peng Wang , Chaojie Dang , Dan Liu
IPC分类号： C07D471/04
摘要： The invention relates to a KRAS mutant protein inhibitors of formula (I), a composition containing the inhibitors and the use thereof.
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公开(公告)号：US11180506B2
公开(公告)日：2021-11-23
申请号：US17197095
申请日：2021-03-10
发明人： Amin Li , Sujing Li , Peng Wang , Chaojie Dang , Dan Liu
IPC分类号： C07D487/04 , A61P35/00 , A61K9/00
摘要： The invention relates to a KRAS mutant protein inhibitor shown as formula (I), a composition containing the inhibitor and the use thereof.
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