公开(公告)号：US10988466B2

公开(公告)日：2021-04-27

申请号：US16496655

申请日：2018-03-23

申请人： Jacobio Pharmaceuticals Co., Ltd.

发明人： Cunbo Ma ,  Panliang Gao ,  Shaojing Hu ,  Zilong Xu ,  Huifeng Han ,  Xinping Wu ,  Di Kang

IPC分类号： C07D471/10 ,  C07D413/14 ,  C07D401/04 ,  C07D401/14 ,  C07D471/20 ,  C07D491/107 ,  C07D495/10 ,  C07D513/10

摘要： This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

公开(公告)号：US20210393623A1

公开(公告)日：2021-12-23

申请号：US17280573

申请日：2019-09-26

申请人： Jacobio Pharmaceuticals Co., Ltd.

发明人： Huifeng Han ,  Panliang Gao ,  Cunbo Ma ,  Di Kang

IPC分类号： A61K31/497 ,  C07D401/04 ,  C07D471/10 ,  C07D401/14 ,  C07D495/10 ,  C07D487/04 ,  C07D513/10 ,  C07D417/04 ,  C07D519/00 ,  C07D491/107 ,  C07D513/04 ,  C07D405/14 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/519 ,  A61K31/513 ,  A61K31/4545 ,  A61K31/501 ,  A61K31/4985 ,  A61K31/444 ,  A61K31/438 ,  A61K31/53

摘要： The present invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, the present invention provides a pharmaceutical composition comprising the said compound.

公开(公告)号：US20240285617A1

公开(公告)日：2024-08-29

申请号：US18591753

申请日：2024-02-29

申请人： Jacobio Pharmaceuticals Co., Ltd.

发明人： Huifeng Han ,  Panliang Gao ,  Cunbo Ma ,  Di Kang

IPC分类号： A61K31/497 ,  A61K31/438 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107 ,  C07D495/10 ,  C07D513/04 ,  C07D513/10 ,  C07D519/00

CPC分类号： A61K31/497 ,  A61K31/438 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107 ,  C07D495/10 ,  C07D513/04 ,  C07D513/10 ,  C07D519/00 ,  C07B2200/05

摘要： This invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention provides a pharmaceutical composition comprising the said compound.

公开(公告)号：US10858359B2

公开(公告)日：2020-12-08

申请号：US16307827

申请日：2017-06-07

申请人： JACOBIO PHARMACEUTICALS CO., LTD.

发明人： Cunbo Ma ,  Panliang Gao ,  Jie Chu ,  Xinping Wu ,  Chunwei Wen ,  Di Kang ,  Jinlong Bai ,  Xiaoyan Pei

IPC分类号： C07D401/12 ,  C07D471/14 ,  C07D401/14 ,  C07D401/04 ,  C07D491/107 ,  A61P35/00 ,  C07D413/14 ,  C07D471/20 ,  C07D405/14 ,  A61P37/00 ,  A61P27/00 ,  A61P9/00 ,  C07D519/00 ,  C07D471/04

摘要： Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.