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公开(公告)号：US20140178990A1
公开(公告)日：2014-06-26
申请号：US14163371
申请日：2014-01-24
发明人： Tetsuhiko YOSHIDA , Nahoko KOBAYASHI , Mikio NIWA , Chikara SHINOHARA , Masatoki WATANABE , Ken-ichiro HATA
IPC分类号： C12N5/0775 , C07K7/08 , C07K7/06 , C07K14/00
CPC分类号： C12N5/0662 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/475 , C07K2319/10 , C07K2319/21 , C07K2319/23 , C12N5/0018 , C12N2501/998
摘要： A method for manufacturing at least one kind of eukaryotic cells or a biosynthetic substance derived from the eukaryotic cells by proliferating the cells, which includes preparing an artificially synthesized peptide for promoting proliferation of the at least one kind of eukaryotic cells, incubating the eukaryotic cells in a culture medium, and adding the synthesized peptide at least once to the culture medium during the incubation process. The synthesized peptide includes an amino acid sequence selected from SEQ ID NOS: 1 to 18, and an amino acid sequence selected from SEQ ID NOS: 19 to 97.
摘要翻译： 一种用于通过增殖细胞来制造至少一种真核细胞或源自真核细胞的生物合成物质的方法，其包括制备用于促进至少一种真核细胞增殖的人造合成肽，将真核细胞孵育 培养基，并且在孵育过程中将合成的肽至少一次加入到培养基中。 合成的肽包括选自SEQ ID NO：1至18的氨基酸序列和选自SEQ ID NO：19至97的氨基酸序列。
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公开(公告)号：US20180064849A1
公开(公告)日：2018-03-08
申请号：US15705826
申请日：2017-09-15
CPC分类号： A61L27/3654 , A61F2002/30766 , A61K35/28 , A61K35/32 , A61K38/17 , A61K38/39 , A61L27/222 , A61L27/3834 , A61L27/3852 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/06
摘要： An object of the invention is to provide a cartilage regenerative material that is capable of regenerating bone and cartilage using cells. Provided is a cartilage regenerative material including a cell construct, which includes biocompatible polymer blocks and stem cells, in which a plurality of the biocompatible polymer blocks are disposed in gaps between a plurality of the stem cells.
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公开(公告)号：US20190216976A1
公开(公告)日：2019-07-18
申请号：US15705669
申请日：2017-09-15
CPC分类号： A61L27/222 , A61L27/00 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/3612 , A61L27/3633 , A61L27/3654 , A61L27/3817 , A61L27/3852 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/06 , A61L2430/24
摘要： An object of the invention is to provide a cartilage regenerative material that suppresses infiltration of fibrous soft tissue and brings about satisfactory cartilage regeneration, and a method for producing the cartilage regenerative material. Provided is a cartilage regenerative material including a porous body of a biocompatible polymer and a biocompatible polymer film, in which the porous body contains chondrocytes and cartilage matrix, and the cartilage matrix exists in a region of 10% or more of a region extending from the surface of the transplant face of the porous body to a depth of 150 μm along the thickness.
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公开(公告)号：US20200069841A1
公开(公告)日：2020-03-05
申请号：US16660003
申请日：2019-10-22
IPC分类号： A61L27/36 , A61K35/32 , A61L27/38 , A61L27/54 , A61L27/56 , A61K38/39 , A61K35/28 , A61K38/17 , A61L27/22
摘要： An object of the invention is to provide a cartilage regenerative material that is capable of regenerating bone and cartilage using cells. Provided is a cartilage regenerative material including a cell construct, which includes biocompatible polymer blocks and stem cells, in which a plurality of the biocompatible polymer blocks are disposed in gaps between a plurality of the stem cells.
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