Multi-stage biodegradable drug delivery platform

    公开(公告)号:US11944780B2

    公开(公告)日:2024-04-02

    申请号:US16663173

    申请日:2019-10-24

    申请人: InCube Labs, LLC

    发明人: Mir Imran

    摘要: Embodiments of the invention provide multi-stage biodegradable drug delivery platforms and methods for the subcutaneous delivery of therapeutic agents (TA). Embodiments of the platform may be configured to subcutaneously deliver a first dose of a first TA which is absorbed into the body and/or blood stream (BBS) to produce a first therapeutic effect for a first selectable time period (STP), and subsequently after a second STP, deliver a second dose of a second TA which is absorbed into the BBS to produce a second therapeutic effect for a third STP. An embodiment of the platform may comprise a body having a tissue-penetrating end, a primary cavity having a first TA dose and a shell having a secondary cavity having a second TA dose. The first TA dose is released after the first STP and the second TA dose is released after the second STP by biodegradation of the shell.

    INTRACRANIAL DELIVERY OF MEDICINAL SOLUTION

    公开(公告)号:US20220296868A1

    公开(公告)日:2022-09-22

    申请号:US17631251

    申请日:2020-07-30

    申请人: InCube Labs, LLC

    发明人: Mir Imran Mir Hashim

    IPC分类号: A61M39/02

    摘要: Embodiments provide for intracranial delivery of a medicinal solution to the brain. A system includes a bun hole stopple for insertion in a cranial bun hole, a catheter, a connecting member, a connector tube, and a pump. The catheter is advanced through an opening in the stopple to a tissue site in the brain. A proximal portion of the catheter is fixed to an outer groove in the stopple to minimize movement of the catheter in the brain. The catheter, connecting member, connector tube, and pump are fluidically coupled together to create a flow path between the pump and a distal end of the catheter for infusion of the medicinal solution to the tissue site in the brain.

    Method for treating diabetes and other glucose regulation disorders using stem cells

    公开(公告)号:US11077146B2

    公开(公告)日:2021-08-03

    申请号:US16555987

    申请日:2019-08-29

    申请人: INCUBE LABS, LLC

    发明人: Mir Imran

    IPC分类号: C12N5/071 A61K35/38 A61K35/28

    摘要: Various embodiments of the invention provide methods of treating diabetes and other glucose regulation disorders. In one embodiment, the method comprises removing L-cells from a donor, obtaining stem cells from a patient, and culturing the L-cells in the presence of the stem cells under conditions such that the stem cells differentiate into stem cell-derived L-cells (SCDLC). An amount of the SCDLC is introduced into the patient sufficient to cause a lowering of the patient's blood glucose level after ingestion of food. In another embodiment, the method comprises removing K-cells from a donor, obtaining stem cells from a patient, and culturing the K-cells in the presence of the stem cells under conditions such that the stem cells differentiate into stem cell-derived K-cells (SCDKC). An amount of the SCDKC is introduced into the patient sufficient to cause a lowering of the patient's blood glucose level after ingestion of food.

    Implantable solid-liquid drug delivery apparatus, formulations, and methods of use

    公开(公告)号:US10758668B2

    公开(公告)日:2020-09-01

    申请号:US16214943

    申请日:2018-12-10

    申请人: InCube Labs, LLC

    发明人: Mir Imran

    摘要: Embodiments provide apparatus and methods for delivering liquid form medication within the body wherein the medication is stored in solid form and then mixed with a liquid in an apparatus implanted within the body. One embodiment provides an implantable apparatus for in vivo delivery of medication comprising a housing including a reservoir, a store of solid form medication (SSM) and a pump. An SSM element is added to the reservoir along with fluid to form a medication solution comprising at least one drug. The medication solution is then delivered to a delivery site using a pumping means to pump solution from the reservoir through a delivery member such as catheter to a delivery site. Embodiments of the invention are particularly useful for delivering medication to a patient to treat a medical condition over an extended period of time without requiring the patient to take external medication.

    Urethral catheters and methods for facilitated introduction into the urinary tract

    公开(公告)号:US10589093B2

    公开(公告)日:2020-03-17

    申请号:US15448501

    申请日:2017-03-02

    申请人: Incube Labs, LLC

    发明人: Mir Imran

    摘要: Embodiments of the invention provide apparatus, systems and methods for facilitating introduction of a urinary drainage catheter (UDC) into the urinary tract (UT). One embodiment provides a UDC including electrodes for delivering high frequency current to a patient's pudendal nerves to relax the urinary sphincter (US) before passing the UDC therethrough so as reduce the resistance force on the UDC and discomfort to the patient. The electrodes can comprise at least one pair of bipolar electrodes and may be flexible so as to bend and flex within the urethra. The UDC includes one or more lumens including a drainage lumen and an inflation lumen for inflating an anchoring device on the UDC. The UDC can include a pressure sensor to assess relaxation of the US. The UDC may include a second set of electrodes and irrigation lumen for relaxing the US and flushing the urethra with the UDC in place.

    Device, system and methods for measurement of pressures in the urinary tract

    公开(公告)号:US10542924B2

    公开(公告)日:2020-01-28

    申请号:US15153314

    申请日:2016-05-12

    申请人: InCube Labs, LLC

    摘要: A catheter for measuring pressure in the urinary tract of a patient includes a catheter body having a proximal and distal end. A plurality of lumens is formed in the catheter body, and an adaptor is coupled to the proximal end of the catheter body. The adaptor includes a port for each lumen. A first pressure sensor, typically including a balloon, is fluidically coupled to a first lumen and is configured and positioned to measure pressure in a urethra of the patient. A second pressure sensor, also typically including a balloon, is fluidically coupled to a second lumen and is configured and positioned on the catheter body to measure pressure in a bladder of the patient. An expandable retention member, which may be coupled to a third lumen, is positioned on the catheter body between the first and second expandable pressure sensors so that the catheter body may be retained at a selected location in the urinary tract to properly position the fluid pressure sensors in the bladder and urethra, respectively.

    Methods for delivery of optical signals to tissue for the treatment of a disease or condition

    公开(公告)号:US10315044B2

    公开(公告)日:2019-06-11

    申请号:US15858781

    申请日:2017-12-29

    申请人: InCube Labs, LLC

    发明人: Mir Imran

    摘要: Embodiments described herein provide methods for treating various conditions and diseases using an optical signal. In one or more embodiments an apparatus is providing having an optical window, which is used to deliver an optical signal to provide stimulation to one or more tissue sites in the body such as the brain, optic nerve, eye, ganglia, spine, or other like site. The optical signals can be used to treat a variety of neurological diseases and conditions including epilepsy, migraine headaches and chronic pain. In particular applications the optical signals can be used to treat, inhibit or prevent epileptic or other neurological seizures by providing an optical input to a foci or surrounding tissue in the brain causing the seizure. The optical signal may also be combined with an electrical signal to produce an aggregate effect in tissue for treating the disease or condition such as a neurological disease or condition.

    IMPLANTABLE SOLID-LIQUID DRUG DELIVERY APPARATUS, FORMULATIONS, AND METHODS OF USE

    公开(公告)号:US20190117879A1

    公开(公告)日:2019-04-25

    申请号:US16214943

    申请日:2018-12-10

    申请人: InCube Labs, LLC

    发明人: Mir Imran

    摘要: Embodiments provide apparatus and methods for delivering liquid form medication within the body wherein the medication is stored in solid form and then mixed with a liquid in an apparatus implanted within the body. One embodiment provides an implantable apparatus for in vivo delivery of medication comprising a housing including a reservoir, a store of solid form medication (SSM) and a pump. An SSM element is added to the reservoir along with fluid to form a medication solution comprising at least one drug. The medication solution is then delivered to a delivery site using a pumping means to pump solution from the reservoir through a delivery member such as catheter to a delivery site. Embodiments of the invention are particularly useful for delivering medication to a patient to treat a medical condition over an extended period of time without requiring the patient to take external medication.

    Method for the detection and treatment of aberrant neural-electric activity

    公开(公告)号:US10264987B2

    公开(公告)日:2019-04-23

    申请号:US13917627

    申请日:2013-06-13

    申请人: InCube Labs, LLC

    发明人: Mir Imran

    摘要: An apparatus for detection of ANEA comprising an introducer having at least one lumen. The introducer is introduced into brain tissue through an opening in the skull. A reference electrode is positioned at an introducer distal portion. A plurality of electrode members are advanceable within the at least one lumen with each member having an insulated portion and an exposed distal portion. The members have a non-deployed state in the introducer and a deployed state when outwardly advanced out of the introducer. In the deployed state, the members are substantially orthogonal to each other with the exposed distal portions defining a detection volume capable of determining an electric field vector produced by the ANEA and the direction of foci of the ANEA.

    SYSTEM AND METHOD FOR TREATMENT OF HEMORRHAGIC STROKE

    公开(公告)号:US20190054279A1

    公开(公告)日:2019-02-21

    申请号:US16167288

    申请日:2018-10-22

    申请人: InCube Labs, LLC

    发明人: Mir Imran

    摘要: Embodiments of the invention provide apparatus, methods and systems for delivering treatments and for medications to the site of an aneurysm (SOA). One embodiment of a method comprises delivering a neural growth stimulating factor (NGSF) to the site of the aneurysm to grow new nerve cells and/or stimulate the regeneration of damaged nerve cells. The NGSF may be delivered in a carrier such as a gel which can be selected to allow for long term delivery of the NGSF to the SOA. In many embodiments, the NGSF may be delivered to the SOA using a microcatheter based system which includes a microcatheter that can be advanced in the cerebral vasculature. The microcatheter may also be used to delivery occlusive element to the SOA such as occlusive coils or balloon which promote clotting and reduce bleeding at the SOA and together with the carrier allow for long term release of NGSF.