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公开(公告)号：US11730923B2
公开(公告)日：2023-08-22
申请号：US17842386
申请日：2022-06-16
Applicant: InCube Labs, LLC
Inventor： Mir A. Imran
CPC classification number: A61M25/0075 , A61M25/007 , A61M39/10 , A61M2025/0042 , A61M2202/0007
Abstract: An illustrative drug delivery system implantable in a recipient may include a connection assembly, a source catheter, and a microcatheter. A proximal end portion of the source catheter may be configured to be fluidically connected to a fluid source configured to provide a fluid (e.g., a neurotherapeutic drug). A distal end portion of the source catheter may be configured to be fluidically connected to the connection assembly. The microcatheter may include a proximal end portion configured to be fluidically connected to the connection assembly and a distal end portion comprising an elution opening configured to elute the fluid to a target location (e.g., a brain) within a recipient. The fluid source may be configured to provide the fluid to the target location by way of the source catheter, the connection assembly, and the microcatheter.
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公开(公告)号：US20230047024A1
公开(公告)日：2023-02-16
申请号：US17873419
申请日：2022-07-26
Applicant: InCube Labs, LLC
Inventor： Kyle HORLEN , Charles Gregory NELSON
Abstract: A trocar assembly comprises an elongate shaft, a piercing tip at a distal end of the shaft, a handle at a proximal end of the shaft, and a retaining member. When a passer tube is positioned over the shaft, the retaining member engages with an inner surface or an outer surface of the passer tube to retain a position of the passer tube over the shaft.
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公开(公告)号：US11490844B2
公开(公告)日：2022-11-08
申请号：US16719671
申请日：2019-12-18
Applicant: InCube Labs, LLC
Inventor： Mir Imran , Ben Tranchina
Abstract: A catheter for measuring pressure in the urinary tract of a patient includes a catheter body having a proximal and distal end. A plurality of lumens is formed in the catheter body, and an adaptor is coupled to the proximal end of the catheter body. The adaptor includes a port for each lumen. A first pressure sensor, typically including a balloon, is fluidically coupled to a first lumen and is configured and positioned to measure pressure in a urethra of the patient. A second pressure sensor, also typically including a balloon, is fluidically coupled to a second lumen and is configured and positioned on the catheter body to measure pressure in a bladder of the patient. An expandable retention member, which may be coupled to a third lumen, is positioned on the catheter body between the first and second expandable pressure sensors so that the catheter body may be retained at a selected location in the urinary tract to properly position the fluid pressure sensors in the bladder and urethra, respectively.
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公开(公告)号：US11439819B2
公开(公告)日：2022-09-13
申请号：US16743361
申请日：2020-01-15
Applicant: InCube Labs, LLC
Inventor： Mir Imran
Abstract: Embodiments of the invention provide apparatus, systems and methods for facilitating introduction of a urinary drainage catheter (UDC) into the urinary tract (UT). One embodiment provides a UDC including electrodes for delivering high frequency current to a patient's pudendal nerves to relax the urinary sphincter (US) before passing the UDC therethrough so as reduce the resistance force on the UDC and discomfort to the patient. The electrodes can comprise at least one pair of bipolar electrodes and may be flexible so as to bend and flex within the urethra. The UDC includes one or more lumens including a drainage lumen and an inflation lumen for inflating an anchoring device on the UDC. The UDC can include a pressure sensor to assess relaxation of the US. The UDC may include a second set of electrodes and irrigation lumen for relaxing the US and flushing the urethra with the UDC in place.
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公开(公告)号：US20220257502A1
公开(公告)日：2022-08-18
申请号：US17715870
申请日：2022-04-07
Applicant: INCUBE LABS, LLC
Inventor： Mir A. IMRAN
Abstract: A desired elution profile can be identified, and a delivery device designed to effect the desired elution profile, such as by selecting materials for the constituent components of the delivery device, designing a structure of the delivery device and its constituent components, and selecting a content of formulations, to provide for the designed elution profile at particular expected conditions or at particular times or both.
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Patent Agency Ranking
公开(公告)号：US20220216473A1
公开(公告)日：2022-07-07
申请号：US17703538
申请日：2022-03-24
Applicant: INCUBE LABS, LLC
Inventor： Mir A. IMRAN , Radia Abdul WAHAB , Chang Jin ONG
IPC: H01M4/54 , H01M4/62 , H01M10/04 , H01M4/38 , H01M50/121
Abstract: A base cell structure includes a containment ring defining an opening extending therethrough. An inner wall of the containment ring defines a perimeter limit of a base cell volume. The containment ring provides a liquid-impermeable casing at the perimeter limit. A first set of active particles is disposed in the base cell volume of a first base cell structure to form an anode cell. A second set of active particles is disposed in the base cell volume of a second base cell structure to form a cathode cell. The anode cell and the cathode cell are assembled together with a separator disposed between. Two electrode plates are disposed on the assembly, one adjacent to the anode cell and one adjacent to the cathode cell, to respectively provide an anode electrode plate and a cathode electrode plate which are disposed on opposite outer sides of the assembly.
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公开(公告)号：US11331424B2
公开(公告)日：2022-05-17
申请号：US16534801
申请日：2019-08-07
Applicant: InCube Labs, LLC
Inventor： Mir Imran , Phillip Morgan , Ben Tranchina , Paul Spehr , Kyle Horlen
IPC: A61M37/00 , A61M5/142 , A61M5/14 , A61N1/39 , A61B5/00 , A61B5/0531 , A61B5/055 , A61N1/05 , A61N1/36 , A61N1/362 , A61B5/30 , A61B5/287 , A61B5/291
Abstract: Various embodiments provide an apparatus, system method for treating neurological conditions by delivering solid form medication to the ventricles or other areas of the brain. Particular embodiments provide an apparatus and method for treating epilepsy and other neurological conditions by delivering solid form medication to ventricles in the brain wherein the medication is contained in a diffusion chamber so as to allow the medication to dissolve in the cerebrospinal fluid of the brain and then diffuse out of the diffusion chamber to be delivered to the ventricles and brain tissue. In one or more embodiments, portions of apparatus have sufficient flexibility to conform to the shape of the ventricles of the brain when advanced into them and/or to not cause deformation of the ventricle sufficient to cause a significant physiologic effect.
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8.发明申请公开(公告)号：US20200206132A1
公开(公告)日：2020-07-02
申请号：US16731834
申请日：2019-12-31
Applicant: InCube Labs, LLC
Inventor： Mir Imran , Radhika Korupolu , Simret Beraki , April Lynn Toledo , Mir Hashim
IPC: A61K9/00 , A61M5/158 , A61M25/10 , A61K9/48 , A61K39/395
Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents (TA) within the GI tract. Many embodiments provide a swallowable device such as a capsule for delivering TAs into the intestinal wall (IW) or other GI location. Embodiments also provide various TA preparations such as IgG that are configured to be contained within the capsule, advanced from the capsule into the IW and degrade to release the TA into the bloodstream where they exhibit a selected plasma concentration profile which may have selected pharmacokinetic parameters. The preparation can be operably coupled to a delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
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公开(公告)号：US10695561B2
公开(公告)日：2020-06-30
申请号：US15667175
申请日：2017-08-02
Applicant: InCube Labs, LLC
Inventor： Mir A. Imran
Abstract: Embodiments of the invention provide patch assemblies for iontophoretic transdermal delivery of therapeutic agents. An embodiment provides a patch assembly comprising a conformable patch for delivery of the agent and having a tissue contacting side including an adhesive. The housing has a bottom surface for engaging a non-tissue contacting side of the patch, a current source such as a battery and a controller for controlling the delivery of the agent. The housing has sufficient flexibility such that when it is engaged with the patch to form the patch assembly and the patch is adhered to a target site on the patient's skin, the assembly has sufficient flexibility to deform with movement of the patient's skin to remain sufficiently adhered to the skin over an extended period of time to transdermally deliver a desired dose of the agent.
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公开(公告)号：US20200069939A1
公开(公告)日：2020-03-05
申请号：US16567342
申请日：2019-09-11
Applicant: InCube Labs, LLC
Inventor： Mir Imran
IPC: A61N1/36
Abstract: A system for controlling urination in a patient includes an implantable controller and an external device. The implantable controller includes circuitry and electrodes for stimulating the pudenal nerves in order to control urination. In addition, the implantable controller includes sensors for determining information on bladder fullness and for transmitting such information to an external device which is used for controlling the implanted controller. The external device will display when bladder filling exceeds a safe threshold level, allowing the patient and a caregiver to take appropriate steps to allow the patient to urinate.
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