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公开(公告)号：US10975363B2
公开(公告)日：2021-04-13
申请号：US16372072
申请日：2019-04-01
摘要： Provided herein are novel, synthetic polypeptides having, for example, acyl-acyl carrier protein (ACP) thioesterase (TE) activity, including polypeptides that convert pimeloyl-ACP to pimelic acid. In some aspects, the synthetic polypeptides have advantageous enzymatic activity and/or improved substrate specificity relative to a wild type acyl-ACP TE.
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公开(公告)号：US11634736B2
公开(公告)日：2023-04-25
申请号：US16264781
申请日：2019-02-01
摘要： Methods and materials for the production of compounds involved in the TCA cycle, and/or derivatives thereof and/or compounds related thereto are provided. Also provided are products produced in accordance with these methods and materials.
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公开(公告)号：US11098381B2
公开(公告)日：2021-08-24
申请号：US16398384
申请日：2019-04-30
摘要： Methods for increasing carbon-based chemical product yield in an organism by genetically modifying one or more genes involved in a stringent response and/or in a regulatory network, nonnaturally occurring organisms having increased carbon-based chemical product yield, and methods for use in production of carbon-based chemical products are provided.
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公开(公告)号：US12060596B2
公开(公告)日：2024-08-13
申请号：US16399145
申请日：2019-04-30
发明人： Alexander Brett Foster , Cristina Serrano Amatriain , Gary J. Smith , Paul Sheldon Pearlman , Mark Paul Taylor , Jonathan Combe , Daniel Bawdon
CPC分类号： C12P7/625 , C12N1/20 , C12N9/0006 , C12N9/1029 , C12N9/13 , C12N9/88 , C12P7/04 , C12P7/065 , C12P7/42 , C12Y101/01001 , C12Y203/01016 , C12Y208/03015 , C12Y401/01004 , C12N2500/02 , C12N2500/05 , C12N2500/12 , C12N2500/24
摘要： Provided herein are methods for increasing the yield of an extracellular product synthesized by an organism cultured in a continuous aerobic fermentation system. The extracellular product yield is increased through the use of an organism modified to decreased production of polyhydroxyalkanoate, to increase production of the extracellular product, and to include promoters that can be inducible in response to nutrient limitation conditions. The extracellular product yield is also increased by operating the continuous fermentation system under particular nutrient limitation conditions. Also provided are non-naturally occurring organisms that have been modified for use with the provided methods, and extracellular products made using the provided methods.
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公开(公告)号：US11999943B2
公开(公告)日：2024-06-04
申请号：US16398401
申请日：2019-04-30
CPC分类号： C12N1/205 , C12N9/0073 , C12N9/14 , C12N15/52 , C12N15/68 , C12P7/16 , C12R2001/38 , C12Y401/01031 , C12Y401/01032 , C12Y604/01001
摘要： Methods of redirecting carbon flux and increasing C2/C3 or a C4/5/6 carbon chain length carbon-based chemical product yield in an organism, nonnaturally occurring organisms with redirected carbon flux and increased C2/C3 or C4/5/6 carbon chain length carbon-based chemical product yield and methods for using these organisms in production of C2/C3 or C4/5/6 carbon chain length carbon-based chemical products are provided.
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公开(公告)号：US11788055B2
公开(公告)日：2023-10-17
申请号：US16398351
申请日：2019-04-30
CPC分类号： C12N1/205 , C12N9/14 , C12N15/78 , C12P7/16 , C12P7/18 , C12P7/54 , C12R2001/38 , C12Y101/01 , C12Y203/01
摘要： Methods for increasing carbon-based chemical product yield in an organism by perturbing redox balance in an organism as well as nonnaturally occurring organisms with perturbed redox balance and methods for their use in producing carbon-based chemical products are provided.
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公开(公告)号：US11661613B2
公开(公告)日：2023-05-30
申请号：US16264739
申请日：2019-02-01
CPC分类号： C12P7/42 , C12N1/205 , C12N9/1029 , C12N9/90 , C12R2001/01 , C12Y203/01009
摘要： Methods and materials for the production of hydroxy fatty acid anions, including 2-hydroxyisobutyric acid (2-HIBA), and/or derivatives thereof and compounds related thereto are provided. Also provided are products produced in accordance with these methods and materials.
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8.发明授权公开(公告)号：US11702680B2
公开(公告)日：2023-07-18
申请号：US16399155
申请日：2019-04-30
发明人： Alexander Brett Foster , Cristina Serrano Amatriain , Gary J. Smith , Paul Sheldon Pearlman , Mark Paul Taylor
CPC分类号： C12P7/625 , C12N1/20 , C12N9/0006 , C12N9/1029 , C12N9/13 , C12N9/88 , C12P7/04 , C12P7/065 , C12P7/42 , C12Y101/01001 , C12Y203/01016 , C12Y208/03015 , C12Y401/01004 , C12N2500/02 , C12N2500/05 , C12N2500/12 , C12N2500/24
摘要： Provided herein are methods for generating cellular biomass in continuous aerobic fermentation systems. The biomass yield, and the concentration of polyhydroxyalkanoate within the biomass, are each directed to advantageous levels by operating the continuous fermentation system under particular nutrient limitation conditions. Also provided are biomass produced using the provided methods, and animal feed compositions including the provided biomass.
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公开(公告)号：US11203771B2
公开(公告)日：2021-12-21
申请号：US16372083
申请日：2019-04-01
摘要： This disclosure relates to strategies for in vivo production of certain carbon-based products, for example, aminated aliphatic compounds having a carbon chain length of C5-C19.
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公开(公告)号：US11268110B2
公开(公告)日：2022-03-08
申请号：US16656816
申请日：2019-10-18
IPC分类号： C12P7/40 , C12P7/04 , C12P7/46 , C12P7/64 , C12P13/00 , C12P7/42 , C12P7/50 , C07C47/21 , C07C59/147 , C08G69/10 , C08G69/26 , C12N9/02 , C12N9/10 , C12N9/80 , C12N9/88 , C12N9/90 , C12P7/24 , C12P17/18 , C12P7/6427 , C12P7/6409
摘要： This document describes biochemical pathways for producing pimeloyl-CoA using a polypeptide having the enzymatic activity of a hydroperoxide lyase to form non-3-enal and 9-oxononanoate from 9-hydroxyperoxyoctadec-10,12-dienoate. Non-3-enal and 9-oxononanoate can be enzymatically converted to pimeloyl-CoA or a salt thereof using one or more polypeptides having the activity of a dehydrogenase, a CoA ligase, an isomerase, a reductase, a thioesterase, a monooxygenase, a hydratase, and/or a thiolase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, or 1,7-heptanediol, or corresponding salts thereof. This document also describes recombinant microorganisms producing pimeloyl-CoA, as well as pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, and 1,7-heptanediol, or corresponding salts thereof.
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