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公开(公告)号：US20230055694A1
公开(公告)日：2023-02-23
申请号：US17936102
申请日：2022-09-28
IPC分类号： C07K16/30 , A61K35/17 , A61P35/00 , C07K14/705
摘要： Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.
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公开(公告)号：US20230227576A1
公开(公告)日：2023-07-20
申请号：US18157027
申请日：2023-01-19
发明人： John Bridgeman , Robert Hawkins , Ruben Rodriguez , Gray Kueberuwa , Milena Kalaitsidou , Michael Gavin King
IPC分类号： C07K16/30 , C07K7/06 , C07K14/715 , C07K14/725 , A61K35/17 , C12N5/0783
CPC分类号： C07K16/3007 , C07K7/06 , C07K14/715 , C07K14/7051 , C07K16/30 , A61K35/17 , C12N5/0636 , A61K39/00
摘要： The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.
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公开(公告)号：US11945876B2
公开(公告)日：2024-04-02
申请号：US17807109
申请日：2022-06-15
CPC分类号： C07K16/3007 , A61K35/17 , A61P35/00 , C07K14/70521 , C07K14/70578 , A61K38/00 , A61K2039/505 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/02 , C07K2319/33
摘要： Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.
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公开(公告)号：US20230002504A1
公开(公告)日：2023-01-05
申请号：US17807109
申请日：2022-06-15
IPC分类号： C07K16/30 , C07K14/705 , A61K35/17 , A61P35/00
摘要： Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.
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公开(公告)号：US20230277670A1
公开(公告)日：2023-09-07
申请号：US18005330
申请日：2021-07-16
发明人： John Bridgeman , Robert Hawkins , Ruben Rodriguez
IPC分类号： A61K39/00 , C07K14/715 , C07K14/705 , C07K14/725 , C12N5/0783
CPC分类号： A61K39/4632 , C07K14/7151 , C07K14/70521 , C07K14/7051 , C12N5/0636
摘要： The present invention relates to a chimeric molecule useful in adoptive cell therapy (ACT), and cells comprising the same. The chimeric molecule can act as a modulator of cellular activity enhancing responses when an endogenous T-cell receptor (TCR) is engaged with its cognate antigen. The present invention also provides proteins, nucleic acids encoding the chimeric molecule and therapeutic uses thereof.
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公开(公告)号：US11697677B2
公开(公告)日：2023-07-11
申请号：US17822251
申请日：2022-08-25
发明人： John Bridgeman , Robert Hawkins , Ruben Rodriguez , Sujita Sukumaran , Xingliang Zhou , Eric Gschweng
IPC分类号： C07K14/705 , C07K14/725 , C07K16/28
CPC分类号： C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/2803 , C07K16/2818 , C07K16/2827 , C07K16/2878 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： The present invention relates to a chimeric molecule useful in adoptive cell therapy (ACT), and cells comprising the same. The chimeric molecule can act as a modulator of cellular activity enhancing responses when an endogenous T-cell receptor (TCR) is engaged with its cognate antigen. The present invention also provides proteins, nucleic acids encoding the chimeric molecule and therapeutic uses thereof.
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公开(公告)号：US20230002470A1
公开(公告)日：2023-01-05
申请号：US17823223
申请日：2022-08-30
IPC分类号： C07K14/725 , C12N5/0783 , C07K14/705 , C12N15/86 , C12N15/62
摘要： The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.
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公开(公告)号：US20240058447A1
公开(公告)日：2024-02-22
申请号：US18323342
申请日：2023-05-24
IPC分类号： A61K39/00 , A61K38/17 , A61K39/395 , C07K14/705 , A61P35/00
CPC分类号： A61K39/464482 , A61K38/1774 , A61K39/39558 , A61K39/4611 , A61K39/4631 , A61K39/464468 , C07K14/70521 , C07K14/70578 , A61K38/1793 , A61P35/00 , C07K2319/03 , C07K2317/622 , A61K2039/505
摘要： Provided herein are methods employing various fusion constructs in T cell therapy. The fusion constructs allow for one to reduce, to the point of full removal if desired, the use of IL-2 that would otherwise accompany an in vivo T cell therapy.
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公开(公告)号：US20230331808A1
公开(公告)日：2023-10-19
申请号：US18316548
申请日：2023-05-12
发明人： John Bridgeman , Robert Hawkins , Ruben Rodriguez , Sujita Sukumaran , Xingliang Zhou , Eric Gschweng
IPC分类号： C07K14/725 , C07K14/705 , C07K16/28
CPC分类号： C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/2803 , C07K16/2818 , C07K16/2827 , C07K16/2878 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： The present invention relates to a chimeric molecule useful in adoptive cell therapy (ACT), and cells comprising the same. The chimeric molecule can act as a modulator of cellular activity enhancing responses when an endogenous T-cell receptor (TCR) is engaged with its cognate antigen. The present invention also provides proteins, nucleic acids encoding the chimeric molecule and therapeutic uses thereof.
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公开(公告)号：US20230059511A1
公开(公告)日：2023-02-23
申请号：US17822251
申请日：2022-08-25
发明人： John Bridgeman , Robert Hawkins , Ruben Rodriguez
IPC分类号： C07K14/725 , C07K14/705 , C07K16/28
摘要： The present invention relates to a chimeric molecule useful in adoptive cell therapy (ACT), and cells comprising the same. The chimeric molecule can act as a modulator of cellular activity enhancing responses when an endogenous T-cell receptor (TCR) is engaged with its cognate antigen. The present invention also provides proteins, nucleic acids encoding the chimeric molecule and therapeutic uses thereof.
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