公开(公告)号：US20230227576A1

公开(公告)日：2023-07-20

申请号：US18157027

申请日：2023-01-19

申请人： Instil Bio (UK) Limited ,  Instil Bio, Inc.

发明人： John Bridgeman ,  Robert Hawkins ,  Ruben Rodriguez ,  Gray Kueberuwa ,  Milena Kalaitsidou ,  Michael Gavin King

IPC分类号： C07K16/30 ,  C07K7/06 ,  C07K14/715 ,  C07K14/725 ,  A61K35/17 ,  C12N5/0783

CPC分类号： C07K16/3007 ,  C07K7/06 ,  C07K14/715 ,  C07K14/7051 ,  C07K16/30 ,  A61K35/17 ,  C12N5/0636 ,  A61K39/00

摘要： The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.