- 专利标题： Receptors providing targeted costimulation for adoptive cell therapy
-
申请号： US17807109申请日： 2022-06-15
-
公开(公告)号： US11945876B2公开(公告)日： 2024-04-02
- 发明人: John Bridgeman , Robert Hawkins , Ruben Rodriguez , Gray Kueberuwa , Milena Kalaitsidou
- 申请人： INSTIL BIO (UK) LIMITED , Instil Bio, Inc.
- 申请人地址： GB TX Manchester
- 专利权人： Instil Bio (UK) Limited,Instil Bio, Inc.
- 当前专利权人： Instil Bio (UK) Limited,Instil Bio, Inc.
- 当前专利权人地址： GB Manchester; US TX Dallas
- 代理机构： KNOBBE, MARTENS, OLSON & BEAR, LLP
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; A61K35/17 ; A61K38/00 ; A61K39/00 ; A61P35/00 ; C07K14/705
摘要：
Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.
公开/授权文献
信息查询
