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公开(公告)号：US20230055694A1
公开(公告)日：2023-02-23
申请号：US17936102
申请日：2022-09-28
IPC分类号： C07K16/30 , A61K35/17 , A61P35/00 , C07K14/705
摘要： Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.
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公开(公告)号：US20230227576A1
公开(公告)日：2023-07-20
申请号：US18157027
申请日：2023-01-19
发明人： John Bridgeman , Robert Hawkins , Ruben Rodriguez , Gray Kueberuwa , Milena Kalaitsidou , Michael Gavin King
IPC分类号： C07K16/30 , C07K7/06 , C07K14/715 , C07K14/725 , A61K35/17 , C12N5/0783
CPC分类号： C07K16/3007 , C07K7/06 , C07K14/715 , C07K14/7051 , C07K16/30 , A61K35/17 , C12N5/0636 , A61K39/00
摘要： The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.
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公开(公告)号：US11945876B2
公开(公告)日：2024-04-02
申请号：US17807109
申请日：2022-06-15
CPC分类号： C07K16/3007 , A61K35/17 , A61P35/00 , C07K14/70521 , C07K14/70578 , A61K38/00 , A61K2039/505 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/02 , C07K2319/33
摘要： Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.
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公开(公告)号：US20230002504A1
公开(公告)日：2023-01-05
申请号：US17807109
申请日：2022-06-15
IPC分类号： C07K16/30 , C07K14/705 , A61K35/17 , A61P35/00
摘要： Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.
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公开(公告)号：US20220348631A1
公开(公告)日：2022-11-03
申请号：US17843480
申请日：2022-06-17
IPC分类号： C07K14/725 , C07K14/705 , C12N15/62 , C12N5/0783 , C12N15/86
摘要： The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.
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公开(公告)号：US20230002470A1
公开(公告)日：2023-01-05
申请号：US17823223
申请日：2022-08-30
IPC分类号： C07K14/725 , C12N5/0783 , C07K14/705 , C12N15/86 , C12N15/62
摘要： The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.
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