公开(公告)号：US12122767B2

公开(公告)日：2024-10-22

申请号：US17038148

申请日：2020-09-30

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Hai Fen Ye ,  Wenqing Yao

IPC分类号： C07D403/14 ,  C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  A61K45/06

CPC分类号： C07D403/14 ,  C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  A61K45/06

摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR3 enzyme and are useful in the treatment of FGFR3-associated diseases such as cancer.

公开(公告)号：US12084449B2

公开(公告)日：2024-09-10

申请号：US17575371

申请日：2022-01-13

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Jincong Zhuo ,  Meizhong Xu ,  Chunhong He ,  Colin Zhang ,  Ding-Quan Qian ,  David M. Burns ,  Yun-Long Li ,  Brian Metcalf ,  Wenqing Yao

IPC分类号： A61P35/00 ,  A61K31/4709 ,  A61K31/53 ,  C07D403/06 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/4709 ,  A61K31/53 ,  A61P35/00 ,  C07D403/06

摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.

公开(公告)号：US11866435B2

公开(公告)日：2024-01-09

申请号：US17992399

申请日：2022-11-22

申请人： Incyte Corporation

发明人： Neil Lajkiewicz ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D471/04 ,  C07D215/40

CPC分类号： C07D471/04 ,  C07D215/40

摘要： Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US11608337B2

公开(公告)日：2023-03-21

申请号：US17032603

申请日：2020-09-25

申请人： Incyte Corporation

发明人： Zhenwu Li ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D513/04 ,  C07D471/04 ,  C07D498/04 ,  C07D487/04

摘要： Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US11566026B2

公开(公告)日：2023-01-31

申请号：US17021581

申请日：2020-09-15

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Bo Shen ,  Meizhong Xu ,  Wenqing Yao

IPC分类号： C07D471/04 ,  C07D513/04 ,  A61P37/04 ,  A61P37/00

摘要： Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US20230024173A1

公开(公告)日：2023-01-26

申请号：US17816271

申请日：2022-07-29

申请人： Incyte Corporation

发明人： Qinda Ye ,  Jingwei Li ,  Ken Mukai ,  Brandon Smith ,  Liangxing Wu ,  Wenqing Yao ,  Min Ye ,  Yingnan Chen ,  Margaret Favata ,  Yvonne Lo

IPC分类号： C07D401/14 ,  A61P35/00 ,  C07D405/14 ,  C07D413/14 ,  C07D471/08 ,  C07D471/10 ,  C07D498/08

摘要： The present application provides imidazolyl pyrimidinylamine inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

公开(公告)号：US20220389033A1

公开(公告)日：2022-12-08

申请号：US17661182

申请日：2022-04-28

申请人： Incyte Corporation

发明人： Alexander Sokolsky ,  Chang Min ,  Xiaozhao Wang ,  Wenqing Yao

IPC分类号： C07D519/00 ,  A61P35/00

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US20220348594A1

公开(公告)日：2022-11-03

申请号：US17848872

申请日：2022-06-24

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Kaijiong Xiao ,  Wenqing Yao

IPC分类号： C07D519/00 ,  A61P37/04

摘要： Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US20220340579A1

公开(公告)日：2022-10-27

申请号：US17719131

申请日：2022-04-12

申请人： Incyte Corporation

发明人： Joshua Hummel ,  David M. Burns ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D487/04 ,  A61P35/00

摘要： The present application provides pyrazolyl bicyclic amines of Formula (I): and their pharmaceutically acceptable salts thereof, that are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

公开(公告)号：US20220315595A1

公开(公告)日：2022-10-06

申请号：US17836602

申请日：2022-06-09

申请人： Incyte Corporation

发明人： Jun Pan ,  Jeremy Roach ,  Song Mei ,  Chunhong He ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D487/04 ,  C07D519/00

摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.