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1.发明申请FUSION PROTEIN COMPRISING FK506 BINDING PROTEIN AND METHOD OF MAKING AND USING THE SAME 有权包含FK506结合蛋白的融合蛋白及其制备和使用方法公开(公告)号：US20080280830A1
公开(公告)日：2008-11-13
申请号：US12144890
申请日：2008-06-24
申请人： Soo Young Choi , Jinseu Park , Won Sik Eum , Dae-Won Kim , Jin-Hee Choi , Tae-Yoon Kim , Hyung-Joo Kwon
发明人： Soo Young Choi , Jinseu Park , Won Sik Eum , Dae-Won Kim , Jin-Hee Choi , Tae-Yoon Kim , Hyung-Joo Kwon
CPC分类号： C12N9/90 , C07K2319/01
摘要： Disclosed is a fusion protein containing a FK506 binding protein and a cell-transducing domain. Also, disclosed is a method of making the fusion protein and use of the fusion protein in a pharmaceutical or cosmetic composition. The cell-transducing domain is, for example, a PEP-1.
摘要翻译： 披露了含有FK506结合蛋白和细胞转导结构域的融合蛋白。 此外，还公开了在药物或化妆品组合物中制备融合蛋白并使用融合蛋白的方法。 细胞转导结构域是例如PEP-1。
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2.发明授权Fusion protein comprising FK506 binding protein and DNA encoding the same 有权包含FK506结合蛋白的融合蛋白和编码该融合蛋白的DNA公开(公告)号：US07902346B2
公开(公告)日：2011-03-08
申请号：US12144890
申请日：2008-06-24
申请人： Soo Young Choi , Jinseu Park , Won Sik Eum , Dae-Won Kim , Jin-Hee Choi , Tae-Yoon Kim , Hyung-Joo Kwon
发明人： Soo Young Choi , Jinseu Park , Won Sik Eum , Dae-Won Kim , Jin-Hee Choi , Tae-Yoon Kim , Hyung-Joo Kwon
CPC分类号： C12N9/90 , C07K2319/01
摘要： Disclosed is a fusion protein containing a FK506 binding protein and a cell-transducing domain. Also, disclosed is a method of making the fusion protein and use of the fusion protein in a pharmaceutical or cosmetic composition. The cell-transducing domain is, for example, a PEP-1.
摘要翻译： 披露了含有FK506结合蛋白和细胞转导结构域的融合蛋白。 此外，还公开了在药物或化妆品组合物中制备融合蛋白并使用融合蛋白的方法。 细胞转导结构域是例如PEP-1。
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3.发明申请Immunostimulatory Compositions Comprising Liposome-Encapsulated Oligonucleotides and Epitopes 有权包含脂质体包封的寡核苷酸和表位的免疫刺激组合物公开(公告)号：US20120114746A1
公开(公告)日：2012-05-10
申请号：US13383898
申请日：2010-06-16
申请人： Hyung-Joo Kwon
发明人： Hyung-Joo Kwon
CPC分类号： A61K47/48815 , A61K31/7088 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/29 , A61K39/39 , A61K45/06 , A61K47/6911 , A61K2039/55555 , A61K2039/55561 , C12N7/00 , C12N2760/16134 , C12N2760/16161 , C12N2760/16171 , C12N2760/18534 , C12N2770/24234 , G01N33/5023 , G01N33/6878 , A61K2300/00
摘要： The present invention relates to a composition for enhancing an immune response, an epitope having immunogenicity, screening and preparing method thereof, a antibody to peptide antigen and screening and preparing method thereof. The composition of the present invention may be effectively used for preventing or treating diverse immune-deficiency diseases such as cancer, influenza virus, hepatitis C virus and RSV (respiratory syncytial virus) by enhancing immune responses.
摘要翻译： 本发明涉及用于增强免疫应答的组合物，具有免疫原性的表位，其筛选及其制备方法，抗体抗体及其筛选及制备方法。 通过增强免疫应答，本发明的组合物可有效地用于预防或治疗各种免疫缺陷疾病如癌症，流感病毒，丙型肝炎病毒和RSV（呼吸道合胞病毒）。
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公开(公告)号：US20090062224A1
公开(公告)日：2009-03-05
申请号：US10589102
申请日：2005-11-04
申请人： Tae-Yoon Kim , Doo-Sik Kim , Hyung-Joo Kwon , Yang-Soon Kim
发明人： Tae-Yoon Kim , Doo-Sik Kim , Hyung-Joo Kwon , Yang-Soon Kim
IPC分类号： A61K31/7125 , A61P37/00 , A61P17/00
CPC分类号： A61K31/7088 , A61K31/7125
摘要： Disclosed is the therapeutic use of CpG oligodeoxynucleotides for skin diseases. The CpG oligodeoxynucleotides (CpG ODNs) of the present invention show excellent immunoactive effects against skin diseases in both cases of CpG ODNs with a phosphorothioate backbone and CpG ODNs with a phosphodiester backbone.
摘要翻译： 公开了CpG寡脱氧核苷酸对皮肤疾病的治疗用途。 本发明的CpG寡脱氧核苷酸（CpG ODNs）在具有硫代磷酸酯骨架的CpG ODNs和具有磷酸二酯骨架的CpG ODNs的情况下都显示出对皮肤疾病的优异的免疫活性。
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5.发明申请Oligonucleotides Derived From Mycobacterium for Stimulating Immune Function, Treating Immune-Related Diseases, Atopic Dermatitis and/or Protecting Normal Immune Cell 有权衍生自分枝杆菌的寡核苷酸用于刺激免疫功能，治疗免疫相关疾病，特应性皮炎和/或保护正常免疫细胞公开(公告)号：US20080249291A1
公开(公告)日：2008-10-09
申请号：US10581656
申请日：2005-01-28
申请人： Hyung-Joo Kwon , Tae-Yoon Kim , Doo-Sik Kim
发明人： Hyung-Joo Kwon , Tae-Yoon Kim , Doo-Sik Kim
IPC分类号： C07H21/04
CPC分类号： C07H21/00 , A61K2039/55561 , A61K2039/57
摘要： Disclosed are oligonucleotides for manipulating an immune reaction. The oligonucleotides of the present invention may be useful to stimulate the immune function, to treat the immune-related diseases and the atopic dermatitis, or to protect the normal immune cells.
摘要翻译： 公开了用于操纵免疫反应的寡核苷酸。 本发明的寡核苷酸可用于刺激免疫功能，治疗免疫相关疾病和特应性皮炎，或保护正常免疫细胞。
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6.发明授权Immunostimulatory compositions comprising liposome-encapsulated oligonucleotides and epitopes 有权包含脂质体包封的寡核苷酸和表位的免疫刺激组合物公开(公告)号：US08889181B2
公开(公告)日：2014-11-18
申请号：US13383898
申请日：2010-06-16
申请人： Hyung-Joo Kwon
发明人： Hyung-Joo Kwon
IPC分类号： A61K9/127 , A61K39/00 , A61P37/04 , A61P31/12 , A61K39/29 , A61K39/155 , A61K31/7088 , A61K45/06 , C12N7/00 , A61K47/48 , A61K39/145
CPC分类号： A61K47/48815 , A61K31/7088 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/29 , A61K39/39 , A61K45/06 , A61K47/6911 , A61K2039/55555 , A61K2039/55561 , C12N7/00 , C12N2760/16134 , C12N2760/16161 , C12N2760/16171 , C12N2760/18534 , C12N2770/24234 , G01N33/5023 , G01N33/6878 , A61K2300/00
摘要： The present invention relates to a composition for enhancing an immune response, an epitope having immunogenicity, screening and preparing method thereof, a antibody to peptide antigen and screening and preparing method thereof. The composition of the present invention may be effectively used for preventing or treating diverse immune-deficiency diseases such as cancer, influenza virus, hepatitis C virus and RSV (respiratory syncytial virus) by enhancing immune responses.
摘要翻译： 本发明涉及用于增强免疫应答的组合物，具有免疫原性的表位，其筛选及其制备方法，抗体抗体及其筛选及制备方法。 通过增强免疫应答，本发明的组合物可有效地用于预防或治疗各种免疫缺陷疾病如癌症，流感病毒，丙型肝炎病毒和RSV（呼吸道合胞病毒）。
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公开(公告)号：US07935678B2
公开(公告)日：2011-05-03
申请号：US10589102
申请日：2005-11-04
申请人： Tae-Yoon Kim , Doo-Sik Kim , Hyung-Joo Kwon , Yang-Soon Kim
发明人： Tae-Yoon Kim , Doo-Sik Kim , Hyung-Joo Kwon , Yang-Soon Kim
CPC分类号： A61K31/7088 , A61K31/7125
摘要： Disclosed is the therapeutic use of CpG oligodeoxynucleotides for skin diseases. The CpG oligodeoxynucleotides (CpG ODNs) of the present invention show excellent immunoactive effects against skin diseases in both cases of CpG ODNs with a phosphorothioate backbone and CpG ODNs with a phosphodiester backbone.
摘要翻译： 公开了CpG寡脱氧核苷酸对皮肤疾病的治疗用途。 本发明的CpG寡脱氧核苷酸（CpG ODNs）在具有硫代磷酸酯骨架的CpG ODNs和具有磷酸二酯骨架的CpG ODNs的情况下都显示出对皮肤疾病的优异的免疫活性。
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8.发明授权Oligonucleotides derived from mycobacterium for stimulating immune function, treating immune-related diseases, atopic dermatitis and/or protecting normal immune cell 有权衍生自分枝杆菌的寡核苷酸用于刺激免疫功能，治疗免疫相关疾病，特应性皮炎和/或保护正常免疫细胞公开(公告)号：US07902161B2
公开(公告)日：2011-03-08
申请号：US10581656
申请日：2005-01-28
申请人： Hyung-Joo Kwon , Tae-Yoon Kim , Doo-Sik Kim
发明人： Hyung-Joo Kwon , Tae-Yoon Kim , Doo-Sik Kim
CPC分类号： C07H21/00 , A61K2039/55561 , A61K2039/57
摘要： Disclosed are oligonucleotides for manipulating an immune reaction. The oligonucleotides of the present invention may be useful to stimulate the immune function, to treat the immune-related diseases and the atopic dermatitis, or to protect the normal immune cells.
摘要翻译： 公开了用于操纵免疫反应的寡核苷酸。 本发明的寡核苷酸可用于刺激免疫功能，治疗免疫相关疾病和特应性皮炎，或保护正常免疫细胞。
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